| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 2.75 | 2.61 | -0.14 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,644,136 | 6,325,658 | -318,478 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 5,660,132 | 5,660,132 | 0 | 1.07 | 0.91 | -0.16 | hold |
| Versant Venture Management, LLC | 5,652,922 | 5,652,922 | 0 | 43.56 | 31.04 | -12.53 | hold |
| BAKER BROS. ADVISORS LP | 4,916,095 | 4,916,095 | 0 | 0.25 | 0.22 | -0.04 | hold |
| BlackRock, Inc. | 3,766,712 | 3,846,454 | +79,742 | 0.00 | 0.00 | -0.00 | buy |
| Avoro Capital Advisors LLC | 4,645,548 | 3,725,000 | -920,548 | 0.34 | 0.29 | -0.04 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,563,798 | 3,360,000 | +1,796,202 | 0.29 | 0.57 | +0.28 | buy |
| VANGUARD GROUP INC | 3,100,036 | 3,140,510 | +40,474 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 4,674,108 | 2,288,034 | -2,386,074 | 0.00 | 0.00 | -0.00 | sell |
| Aisling Capital Management LP | 1,472,331 | 1,472,331 | 0 | 2.37 | 1.85 | -0.52 | hold |
| Alphabet Inc. | 1,464,015 | 1,464,015 | 0 | 0.43 | 0.31 | -0.12 | hold |
| AQR CAPITAL MANAGEMENT LLC | 229,536 | 1,283,942 | +1,054,406 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,004,062 | 1,124,160 | +120,098 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 801,257 | 831,819 | +30,562 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 373,207 | 761,419 | +388,212 | 0.00 | 0.00 | +0.00 | buy |
| Parkwood LLC | 708,000 | 708,000 | 0 | 0.32 | 0.29 | -0.03 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 164,100 | 615,100 | +451,000 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 422,090 | 570,450 | +148,360 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 469,798 | +469,798 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 262,990 | 448,162 | +185,172 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 371,738 | 446,080 | +74,342 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 100,406 | 403,045 | +302,639 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 361,535 | 381,337 | +19,802 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 356,112 | 348,208 | -7,904 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 15,162 | 283,812 | +268,650 | 0.01 | 0.09 | +0.08 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 271,400 | +271,400 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 271,164 | +271,164 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 223,130 | 239,937 | +16,807 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 187,731 | 224,818 | +37,087 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 48,698 | 203,420 | +154,722 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 178,136 | +178,136 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 164,145 | 175,343 | +11,198 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 172,078 | 172,078 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 117,307 | 119,836 | +2,529 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 96,345 | 109,227 | +12,882 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 91,514 | 108,241 | +16,727 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 117,672 | 102,968 | -14,704 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 86,014 | 86,014 | 0 | 0.03 | 0.04 | +0.00 | hold |
| BARCLAYS PLC | 46,210 | 85,712 | +39,502 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 26,949 | 84,488 | +57,539 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 77,918 | +77,918 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 77,635 | +77,635 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 73,975 | +73,975 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 72,500 | +72,500 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 35,346 | 65,389 | +30,043 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 330,467 | 64,631 | -265,836 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 62,239 | 63,585 | +1,346 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 35,140 | 63,480 | +28,340 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 0 | 60,100 | +60,100 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 54,440 | +54,440 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 16,385 | 46,142 | +29,757 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 36,391 | +36,391 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 37,574 | 35,747 | -1,827 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Quantitative Investments LLC | 0 | 35,400 | +35,400 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 28,555 | 33,697 | +5,142 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,323 | 32,354 | +20,031 | 0.01 | 0.01 | +0.01 | buy |
| Stonepine Capital Management, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.13 | +0.13 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 22,062 | 29,870 | +7,808 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 3,706 | 28,326 | +24,620 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 27,251 | 27,251 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,619 | 25,521 | +902 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 23,959 | 24,880 | +921 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 24,356 | 24,356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 24,100 | 24,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 31,114 | 22,913 | -8,201 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 0 | 22,500 | +22,500 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 21,867 | +21,867 | 0.00 | 0.04 | +0.04 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 20,007 | +20,007 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 19,787 | +19,787 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 21,073 | 19,112 | -1,961 | 0.03 | 0.03 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 24,850 | 18,630 | -6,220 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 0 | 16,793 | +16,793 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 17,341 | 16,406 | -935 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,950 | 14,950 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 0 | 14,859 | +14,859 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 0 | 13,182 | +13,182 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,613 | 12,958 | +1,345 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 11,988 | 12,789 | +801 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,174 | 12,174 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 0 | 12,054 | +12,054 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,712 | 11,861 | +149 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 7,595 | 10,857 | +3,262 | 0.00 | 0.00 | +0.00 | buy |
| BRIGHTON JONES LLC | 0 | 10,559 | +10,559 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,635 | 10,435 | -27,200 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 0 | 10,176 | +10,176 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,489 | 9,489 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 2,934 | 5,168 | +2,234 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,843 | 4,992 | +2,149 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,597 | 4,245 | +648 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,184 | 4,184 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 200 | 3,274 | +3,074 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,049 | 3,049 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,875 | 2,748 | -127 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,056 | 2,376 | +320 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,572 | 1,572 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,853 | 1,560 | -293 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,425 | 1,425 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 1,182 | +1,182 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 713 | 1,167 | +454 | 0.00 | 0.00 | +0.00 | buy |