| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 4,535,000 | 5,790,236 | +1,255,236 | 0.23 | 0.45 | +0.22 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,977,587 | 6,601,141 | +623,554 | 0.00 | 0.00 | +0.00 | buy |
| Parkwood LLC | 0 | 426,620 | +426,620 | 0.00 | 0.28 | +0.28 | buy |
| Ikarian Capital, LLC | 0 | 311,593 | +311,593 | 0.00 | 0.51 | +0.51 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 847,442 | 1,044,689 | +197,247 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 173,849 | +173,849 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 995,943 | 1,158,969 | +163,026 | 0.00 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 91,292 | +91,292 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 307,319 | 393,586 | +86,267 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 92,349 | 178,605 | +86,256 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 294,196 | 358,573 | +64,377 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 109,864 | 166,693 | +56,829 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 636,084 | 687,577 | +51,493 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 166,671 | 217,001 | +50,330 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 11,009 | 54,508 | +43,499 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 890,000 | 930,000 | +40,000 | 0.25 | 0.39 | +0.14 | buy |
| HRT FINANCIAL LP | 0 | 38,911 | +38,911 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 311,800 | 346,498 | +34,698 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 25,333 | +25,333 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 24,855 | +24,855 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 9,538 | 30,103 | +20,565 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 19,993 | +19,993 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 18,543 | +18,543 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 102,709 | 117,877 | +15,168 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,457 | +14,457 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,500 | +13,500 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 98,557 | 110,835 | +12,278 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 10,860 | 22,431 | +11,571 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 49,410 | 60,365 | +10,955 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 10,419 | +10,419 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,928 | 30,621 | +9,693 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,600 | 24,100 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,094,974 | 5,101,413 | +6,439 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,270 | 22,617 | +6,347 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,308 | 22,210 | +5,902 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 16,394 | 22,083 | +5,689 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 68,503 | 73,419 | +4,916 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 47,925 | 52,468 | +4,543 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 32,780 | 35,140 | +2,360 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,153 | 13,122 | +1,969 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,241 | 4,184 | +1,943 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,208 | 3,049 | +841 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 15,803 | 16,559 | +756 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,719 | 2,759 | +40 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 52 | 55 | +3 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 193,696 | 193,696 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,916,095 | 4,916,095 | 0 | 0.23 | 0.27 | +0.04 | hold |
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 2.16 | 2.22 | +0.06 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,659,000 | 2,659,000 | 0 | 0.41 | 0.51 | +0.10 | hold |
| Alphabet Inc. | 1,464,015 | 1,464,015 | 0 | 0.28 | 0.42 | +0.14 | hold |
| Castleview Partners, LLC | 18,950 | 18,950 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Aisling Capital Management LP | 1,472,331 | 1,472,331 | 0 | 2.38 | 2.99 | +0.61 | hold |
| Long Corridor Asset Management Ltd | 40,000 | 40,000 | 0 | 0.14 | 0.19 | +0.05 | hold |
| MEEDER ASSET MANAGEMENT INC | 10,050 | 10,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,174 | 12,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 3,100 | 3,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 841 | 841 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 995 | 995 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,950 | 14,950 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 21 | 0 | -21 | 0.00 | 0.00 | 0.00 | sell |
| Russell Investments Group, Ltd. | 2,631 | 0 | -2,631 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 23,422 | 18,291 | -5,131 | 0.00 | 0.00 | +0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 35,686 | 29,798 | -5,888 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,500 | 36,300 | -9,200 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,452 | 1,859 | -11,593 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,547,075 | 2,534,220 | -12,855 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 153,758 | 139,273 | -14,485 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 16,338 | 0 | -16,338 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 16,566 | 0 | -16,566 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 22,665 | 0 | -22,665 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 41,917 | 19,236 | -22,681 | 0.03 | 0.03 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 25,346 | 0 | -25,346 | 0.01 | 0.00 | -0.01 | sell |
| EntryPoint Capital, LLC | 64,339 | 33,219 | -31,120 | 0.11 | 0.10 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 254,714 | 218,700 | -36,014 | 0.00 | 0.00 | +0.00 | sell |
| Sarasin & Partners LLP | 65,081 | 0 | -65,081 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 261,014 | 86,014 | -175,000 | 0.07 | 0.03 | -0.04 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 375,000 | 118,103 | -256,897 | 0.23 | 0.10 | -0.13 | sell |