| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 2.61 | 3.13 | +0.52 | hold |
| BVF INC/IL | 5,660,132 | 5,660,132 | 0 | 0.91 | 1.70 | +0.79 | hold |
| Versant Venture Management, LLC | 5,652,922 | 5,652,922 | 0 | 31.04 | 19.72 | -11.32 | hold |
| BAKER BROS. ADVISORS LP | 4,916,095 | 4,916,095 | 0 | 0.22 | 0.26 | +0.05 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,325,658 | 4,637,060 | -1,688,598 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 3,846,454 | 3,815,133 | -31,321 | 0.00 | 0.00 | +0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,360,000 | 3,360,000 | 0 | 0.57 | 0.75 | +0.18 | hold |
| VANGUARD GROUP INC | 3,140,510 | 2,988,953 | -151,557 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 2,288,034 | 2,812,251 | +524,217 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 1,472,331 | 1,472,331 | 0 | 1.85 | 2.39 | +0.54 | hold |
| Alphabet Inc. | 1,464,015 | 1,464,015 | 0 | 0.31 | 0.45 | +0.14 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,124,160 | 1,151,566 | +27,406 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 446,080 | 902,834 | +456,754 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 831,819 | 846,773 | +14,954 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 800,000 | +800,000 | 0.00 | 0.27 | +0.27 | buy |
| NORTHERN TRUST CORP | 761,419 | 740,684 | -20,735 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 1,283,942 | 717,262 | -566,680 | 0.00 | 0.00 | -0.00 | sell |
| Parkwood LLC | 708,000 | 708,000 | 0 | 0.29 | 0.51 | +0.22 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 694,942 | +694,942 | 0.00 | 0.75 | +0.75 | buy |
| MORGAN STANLEY | 570,450 | 645,196 | +74,746 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 448,162 | 632,182 | +184,020 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 403,045 | 593,394 | +190,349 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 64,631 | 444,939 | +380,308 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 469,798 | 435,767 | -34,031 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 408,540 | +408,540 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 615,100 | 395,733 | -219,367 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381,337 | 383,268 | +1,931 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 271,400 | 358,850 | +87,450 | 0.03 | 0.06 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 307,049 | +307,049 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 271,164 | 269,643 | -1,521 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 215,752 | +215,752 | 0.00 | 0.16 | +0.16 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 46,142 | 203,550 | +157,408 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 200,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 175,343 | 186,798 | +11,455 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 172,078 | 172,078 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 239,937 | 161,481 | -78,456 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 224,818 | 158,524 | -66,294 | 0.00 | 0.00 | +0.00 | sell |
| JBF Capital, Inc. | 0 | 148,566 | +148,566 | 0.00 | 0.16 | +0.16 | buy |
| Qube Research & Technologies Ltd | 203,420 | 147,726 | -55,694 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 283,812 | 133,455 | -150,357 | 0.09 | 0.08 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 119,836 | 118,383 | -1,453 | 0.00 | 0.00 | +0.00 | sell |
| Rangeley Capital, LLC | 0 | 113,000 | +113,000 | 0.00 | 0.79 | +0.79 | buy |
| Nuveen, LLC | 102,968 | 102,968 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GOLDMAN SACHS GROUP INC | 348,208 | 101,144 | -247,064 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 65,389 | 97,898 | +32,509 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 178,136 | 94,707 | -83,429 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 90,419 | +90,419 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 0 | 87,450 | +87,450 | 0.00 | 0.01 | +0.01 | buy |
| Casdin Capital, LLC | 86,014 | 86,014 | 0 | 0.04 | 0.05 | +0.02 | hold |
| MACKENZIE FINANCIAL CORP | 77,635 | 77,635 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 85,712 | 72,955 | -12,757 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 108,241 | 72,095 | -36,146 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 63,585 | 63,946 | +361 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,480 | 63,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IEQ CAPITAL, LLC | 73,975 | 59,066 | -14,909 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 51,133 | +51,133 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 77,918 | 51,009 | -26,909 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 50,213 | +50,213 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 54,440 | 50,128 | -4,312 | 0.01 | 0.02 | +0.01 | sell |
| Brevan Howard Capital Management LP | 35,747 | 46,912 | +11,165 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 84,488 | 43,420 | -41,068 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 36,391 | 40,575 | +4,184 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,697 | 36,280 | +2,583 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 33,113 | +33,113 | 0.00 | 0.01 | +0.01 | buy |
| Arax Advisory Partners | 0 | 32,445 | +32,445 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 32,354 | 30,825 | -1,529 | 0.01 | 0.02 | +0.01 | sell |
| Quantinno Capital Management LP | 16,793 | 30,114 | +13,321 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 19,787 | 28,405 | +8,618 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 28,300 | +28,300 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 27,251 | 27,251 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CWM, LLC | 28,326 | 25,908 | -2,418 | 0.00 | 0.00 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 0 | 24,597 | +24,597 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 18,630 | 24,571 | +5,941 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 24,356 | 24,356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 19,112 | 23,128 | +4,016 | 0.03 | 0.05 | +0.02 | buy |
| JPMORGAN CHASE & CO | 24,880 | 22,939 | -1,941 | 0.00 | 0.00 | +0.00 | sell |
| BAILARD, INC. | 22,500 | 22,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,521 | 21,265 | -4,256 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,435 | 19,835 | +9,400 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 20,007 | 18,543 | -1,464 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 16,406 | 16,406 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Scientech Research LLC | 0 | 16,254 | +16,254 | 0.00 | 0.04 | +0.04 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,489 | 15,997 | +6,508 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,950 | 14,950 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mariner, LLC | 14,859 | 13,763 | -1,096 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 29,870 | 13,405 | -16,465 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,174 | 12,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 12,054 | 12,054 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtu Financial LLC | 0 | 11,952 | +11,952 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 12,789 | 11,724 | -1,065 | 0.00 | 0.00 | +0.00 | sell |
| Pallas Capital Advisors LLC | 13,182 | 11,194 | -1,988 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 72,500 | 11,100 | -61,400 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 10,176 | 11,024 | +848 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 10,871 | +10,871 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,202 | +10,202 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 11,861 | 10,175 | -1,686 | 0.00 | 0.00 | +0.00 | sell |
| WEALTH EFFECTS LLC | 0 | 10,099 | +10,099 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,168 | 9,733 | +4,565 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 4,318 | +4,318 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,245 | 4,245 | 0 | 0.00 | 0.00 | +0.00 | hold |