| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 0 | 800,000 | +800,000 | 0.00 | 0.27 | +0.27 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 694,942 | +694,942 | 0.00 | 0.75 | +0.75 | buy |
| FMR LLC | 2,288,034 | 2,812,251 | +524,217 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 446,080 | 902,834 | +456,754 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 408,540 | +408,540 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 64,631 | 444,939 | +380,308 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 307,049 | +307,049 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 215,752 | +215,752 | 0.00 | 0.16 | +0.16 | buy |
| MACQUARIE GROUP LTD | 0 | 200,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 403,045 | 593,394 | +190,349 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 448,162 | 632,182 | +184,020 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 46,142 | 203,550 | +157,408 | 0.00 | 0.00 | +0.00 | buy |
| JBF Capital, Inc. | 0 | 148,566 | +148,566 | 0.00 | 0.16 | +0.16 | buy |
| Rangeley Capital, LLC | 0 | 113,000 | +113,000 | 0.00 | 0.79 | +0.79 | buy |
| Point72 Asset Management, L.P. | 0 | 90,419 | +90,419 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 271,400 | 358,850 | +87,450 | 0.03 | 0.06 | +0.03 | buy |
| Empowered Funds, LLC | 0 | 87,450 | +87,450 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 570,450 | 645,196 | +74,746 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 51,133 | +51,133 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 0 | 50,213 | +50,213 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 33,113 | +33,113 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 65,389 | 97,898 | +32,509 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 32,445 | +32,445 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 28,300 | +28,300 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,124,160 | 1,151,566 | +27,406 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 24,597 | +24,597 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 16,254 | +16,254 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 831,819 | 846,773 | +14,954 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 16,793 | 30,114 | +13,321 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,952 | +11,952 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 175,343 | 186,798 | +11,455 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 35,747 | 46,912 | +11,165 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 10,871 | +10,871 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,202 | +10,202 | 0.00 | 0.01 | +0.01 | buy |
| WEALTH EFFECTS LLC | 0 | 10,099 | +10,099 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,435 | 19,835 | +9,400 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 19,787 | 28,405 | +8,618 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,489 | 15,997 | +6,508 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 18,630 | 24,571 | +5,941 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,168 | 9,733 | +4,565 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 4,318 | +4,318 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 36,391 | 40,575 | +4,184 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 19,112 | 23,128 | +4,016 | 0.03 | 0.05 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 33,697 | 36,280 | +2,583 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,167 | 3,218 | +2,051 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT WEALTH GROUP LLC / CO | 0 | 2,002 | +2,002 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381,337 | 383,268 | +1,931 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 10,176 | 11,024 | +848 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 591 | +591 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 584 | +584 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 63,585 | 63,946 | +361 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 482 | 598 | +116 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 270 | 318 | +48 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 42 | 84 | +42 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 34 | +34 | 0.00 | 0.00 | 0.00 | buy |
| Turning Point Benefit Group, Inc. | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,376 | 2,388 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 25 | 35 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,049 | 3,051 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,184 | 4,184 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 172,078 | 172,078 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 5,660,132 | 5,660,132 | 0 | 0.91 | 1.70 | +0.79 | hold |
| ALLIANCEBERNSTEIN L.P. | 63,480 | 63,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 12,054 | 12,054 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,916,095 | 4,916,095 | 0 | 0.22 | 0.26 | +0.05 | hold |
| Daiwa Securities Group Inc. | 203 | 203 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 2.61 | 3.13 | +0.52 | hold |
| MetLife Investment Management, LLC | 24,356 | 24,356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 86,014 | 86,014 | 0 | 0.04 | 0.05 | +0.02 | hold |
| Versant Venture Management, LLC | 5,652,922 | 5,652,922 | 0 | 31.04 | 19.72 | -11.32 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,360,000 | 3,360,000 | 0 | 0.57 | 0.75 | +0.18 | hold |
| Parkwood LLC | 708,000 | 708,000 | 0 | 0.29 | 0.51 | +0.22 | hold |
| Alphabet Inc. | 1,464,015 | 1,464,015 | 0 | 0.31 | 0.45 | +0.14 | hold |
| Larson Financial Group LLC | 181 | 181 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aisling Capital Management LP | 1,472,331 | 1,472,331 | 0 | 1.85 | 2.39 | +0.54 | hold |
| Nuveen, LLC | 102,968 | 102,968 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AlphaQuest LLC | 27,251 | 27,251 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SEI INVESTMENTS CO | 16,406 | 16,406 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAILARD, INC. | 22,500 | 22,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 4,245 | 4,245 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,174 | 12,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 841 | 841 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,425 | 1,425 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACKENZIE FINANCIAL CORP | 77,635 | 77,635 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,950 | 14,950 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 1,182 | 1,152 | -30 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 2,748 | 2,700 | -48 | 0.00 | 0.00 | +0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 105 | 50 | -55 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 80 | 0 | -80 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 92 | 0 | -92 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,572 | 1,317 | -255 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 3,274 | 2,987 | -287 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,560 | 1,054 | -506 | 0.00 | 0.00 | +0.00 | sell |
| Focus Partners Wealth | 12,789 | 11,724 | -1,065 | 0.00 | 0.00 | +0.00 | sell |
| Caitong International Asset Management Co., Ltd | 1,066 | 0 | -1,066 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 14,859 | 13,763 | -1,096 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 119,836 | 118,383 | -1,453 | 0.00 | 0.00 | +0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 20,007 | 18,543 | -1,464 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 271,164 | 269,643 | -1,521 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 32,354 | 30,825 | -1,529 | 0.01 | 0.02 | +0.01 | sell |