| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Versant Venture Management, LLC | 0 | 5,652,922 | +5,652,922 | 0.00 | 45.22 | +45.22 | buy |
| BVF INC/IL | 0 | 2,764,471 | +2,764,471 | 0.00 | 0.65 | +0.65 | buy |
| MORGAN STANLEY | 0 | 2,255,353 | +2,255,353 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,901,491 | 3,840,164 | +938,673 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,534,220 | 3,156,354 | +622,134 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,601,141 | 7,116,637 | +515,496 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 5,101,413 | 5,548,448 | +447,035 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 445,868 | +445,868 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 687,577 | 1,076,430 | +388,853 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 173,849 | 499,492 | +325,643 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 13,500 | 278,785 | +265,285 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 154,842 | +154,842 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 0 | 94,633 | +94,633 | 0.00 | 0.09 | +0.09 | buy |
| Cubist Systematic Strategies, LLC | 0 | 92,818 | +92,818 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 86,545 | +86,545 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 18,291 | 70,114 | +51,823 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,210 | 70,162 | +47,952 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 39,647 | +39,647 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 25,333 | 59,399 | +34,066 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 32,366 | +32,366 | 0.00 | 0.13 | +0.13 | buy |
| Squarepoint Ops LLC | 0 | 31,654 | +31,654 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 27,698 | +27,698 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 27,510 | +27,510 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 218,700 | 245,700 | +27,000 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 193,696 | 220,096 | +26,400 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 26,000 | +26,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 346,498 | 370,472 | +23,974 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 358,573 | 376,964 | +18,391 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 17,236 | +17,236 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 60,365 | 76,850 | +16,485 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 54,508 | 70,741 | +16,233 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 30,621 | 46,370 | +15,749 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 30,103 | 44,883 | +14,780 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 14,541 | +14,541 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 13,315 | +13,315 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 13,027 | +13,027 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 12,847 | +12,847 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 11,122 | +11,122 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 52,468 | 61,791 | +9,323 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 9,126 | +9,126 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,457 | 23,230 | +8,773 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,431 | 29,064 | +6,633 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 10,419 | 16,742 | +6,323 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,231 | +6,231 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 55 | 5,921 | +5,866 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 18,543 | 24,094 | +5,551 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 139,273 | 144,811 | +5,538 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 217,001 | 221,741 | +4,740 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 166,693 | 170,312 | +3,619 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,859 | 5,443 | +3,584 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,617 | 24,701 | +2,084 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,047 | +2,047 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 147 | 1,324 | +1,177 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 841 | 1,109 | +268 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 203 | +203 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 116 | +116 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,759 | 2,838 | +79 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,184 | 4,184 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,049 | 3,049 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 35,140 | 35,140 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,916,095 | 4,916,095 | 0 | 0.27 | 0.36 | +0.09 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 29,798 | 29,798 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 7,692,298 | 7,692,298 | 0 | 2.22 | 3.01 | +0.79 | hold |
| MetLife Investment Management, LLC | 24,855 | 24,855 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 86,014 | 86,014 | 0 | 0.03 | 0.04 | +0.01 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 1,464,015 | 1,464,015 | 0 | 0.42 | 0.59 | +0.17 | hold |
| Aisling Capital Management LP | 1,472,331 | 1,472,331 | 0 | 2.99 | 3.63 | +0.64 | hold |
| Long Corridor Asset Management Ltd | 40,000 | 40,000 | 0 | 0.19 | 0.21 | +0.02 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,174 | 12,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 995 | 995 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,950 | 14,950 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 91,292 | 91,274 | -18 | 0.01 | 0.02 | +0.00 | sell |
| Ikarian Capital, LLC | 311,593 | 311,575 | -18 | 0.51 | 0.62 | +0.10 | sell |
| EARNED WEALTH ADVISORS, LLC | 29 | 0 | -29 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 117,877 | 117,412 | -465 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,122 | 12,165 | -957 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 22,083 | 20,533 | -1,550 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 3,100 | 0 | -3,100 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,300 | 32,382 | -3,918 | 0.00 | 0.00 | +0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 19,993 | 14,476 | -5,517 | 0.02 | 0.03 | +0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,044,689 | 1,036,665 | -8,024 | 0.00 | 0.00 | +0.00 | sell |
| MEEDER ASSET MANAGEMENT INC | 10,050 | 0 | -10,050 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 73,419 | 63,283 | -10,136 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 16,559 | 3,597 | -12,962 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 178,605 | 159,874 | -18,731 | 0.00 | 0.00 | +0.00 | sell |
| Castleview Partners, LLC | 18,950 | 0 | -18,950 | 0.04 | 0.00 | -0.04 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 19,236 | 0 | -19,236 | 0.03 | 0.00 | -0.03 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 24,100 | 0 | -24,100 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 33,219 | 0 | -33,219 | 0.10 | 0.00 | -0.10 | sell |
| HRT FINANCIAL LP | 38,911 | 0 | -38,911 | 0.00 | 0.00 | -0.00 | sell |
| Parkwood LLC | 426,620 | 323,000 | -103,620 | 0.28 | 0.28 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 110,835 | 0 | -110,835 | 0.00 | 0.00 | -0.00 | sell |