| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SECTORAL ASSET MANAGEMENT INC | 556,518 | 706,062 | +149,544 | 0.28 | 0.23 | -0.04 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,674,076 | 3,778,393 | +104,317 | 1.62 | 0.91 | -0.72 | buy |
| Formidable Asset Management, LLC | 90,935 | 162,794 | +71,859 | 0.06 | 0.06 | +0.00 | buy |
| SC&H Financial Advisors, Inc. | 21,400 | 71,125 | +49,725 | 0.02 | 0.04 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 402,722 | 442,722 | +40,000 | 0.04 | 0.02 | 0.00 | buy |
| Soleus Capital Management, L.P. | 4,321,197 | 4,356,197 | +35,000 | 1.44 | 0.75 | -0.70 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 29,052 | 29,752 | +700 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 625 | 1,219 | +594 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 61,534 | 61,200 | -334 | 0.03 | 0.02 | -0.01 | sell |
| MYDA Advisors LLC | 60,000 | 40,000 | -20,000 | 0.07 | 0.03 | -0.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,894,942 | 1,796,148 | -98,794 | 0.01 | 0.01 | -0.01 | sell |
| Vivo Capital, LLC | 637,181 | 534,181 | -103,000 | 0.13 | 0.10 | -0.03 | sell |
| Affinity Asset Advisors, LLC | 325,000 | 180,000 | -145,000 | 0.38 | 0.10 | -0.28 | sell |
| ORBIMED ADVISORS LLC | 1,156,175 | 1,009,279 | -146,896 | 0.06 | 0.04 | -0.03 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 756,353 | 528,667 | -227,686 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 1,500,934 | 494,137 | -1,006,797 | 0.03 | 0.01 | -0.02 | sell |