| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 508,776 | 1,111,368 | +602,592 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 40,379 | 192,557 | +152,178 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 132,500 | 200,000 | +67,500 | 0.01 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 451,793 | 507,562 | +55,769 | 4.58 | 5.54 | +0.97 | buy |
| PERCEPTIVE ADVISORS LLC | 403,649 | 444,649 | +41,000 | 0.41 | 0.57 | +0.16 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 28,308 | +28,308 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 22,222 | +22,222 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 18,756 | +18,756 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 13,568 | +13,568 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 3,075 | 11,281 | +8,206 | 0.02 | 0.08 | +0.06 | buy |
| CITADEL ADVISORS LLC | 0 | 6,885 | +6,885 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 5,963 | +5,963 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 69,812 | 75,601 | +5,789 | 0.02 | 0.02 | +0.00 | buy |
| UBS Group AG | 10,161 | 11,535 | +1,374 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 1,059,331 | 1,059,331 | 0 | 2.10 | 2.89 | +0.80 | hold |
| JANE STREET GROUP, LLC | 6,600 | 6,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 251,572 | 251,572 | 0 | 1.02 | 1.20 | +0.19 | hold |
| Commodore Capital LP | 500,000 | 500,000 | 0 | 1.32 | 1.33 | +0.01 | hold |
| SBI Securities Co., Ltd. | 55 | 55 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CITIGROUP INC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| R Squared Ltd | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 26 | 0 | -26 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 92 | 0 | -92 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 135,189 | 135,020 | -169 | 0.01 | 0.01 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 69,124 | 59,748 | -9,376 | 2.50 | 2.50 | -0.01 | sell |
| MORGAN STANLEY | 167,640 | 156,550 | -11,090 | 0.00 | 0.00 | -0.00 | sell |
| Atika Capital Management LLC | 15,000 | 0 | -15,000 | 0.07 | 0.00 | -0.07 | sell |
| Walleye Capital LLC | 103,192 | 85,022 | -18,170 | 0.04 | 0.03 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 44,580 | 19,164 | -25,416 | 0.05 | 0.02 | -0.02 | sell |
| Springhill Fund Asset Management (HK) Co Ltd | 60,648 | 0 | -60,648 | 3.55 | 0.00 | -3.55 | sell |
| Ikarian Capital, LLC | 152,211 | 65,431 | -86,780 | 1.57 | 0.77 | -0.80 | sell |
| Logos Global Management LP | 245,000 | 0 | -245,000 | 1.03 | 0.00 | -1.03 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 460,829 | 206,427 | -254,402 | 0.22 | 0.12 | -0.10 | sell |