| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 0 | 492,319 | +492,319 | 0.00 | 1.00 | +1.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 283,000 | +283,000 | 0.00 | 0.24 | +0.24 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 265,000 | +265,000 | 0.00 | 0.20 | +0.20 | buy |
| BlackRock, Inc. | 394,043 | 621,933 | +227,890 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 220,000 | +220,000 | 0.00 | 3.93 | +3.93 | buy |
| BRAIDWELL LP | 324,358 | 539,708 | +215,350 | 0.81 | 1.31 | +0.50 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 269,641 | 432,515 | +162,874 | 0.14 | 0.23 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 1,155,995 | 1,284,324 | +128,329 | 0.04 | 0.04 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 13,688 | 136,677 | +122,989 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 395,743 | 495,743 | +100,000 | 0.05 | 0.06 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 225,412 | 297,158 | +71,746 | 0.03 | 0.04 | +0.01 | buy |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 120,000 | +70,000 | 0.30 | 0.59 | +0.29 | buy |
| B Group, Inc. | 0 | 67,500 | +67,500 | 0.00 | 3.65 | +3.65 | buy |
| Vivo Capital, LLC | 501,617 | 557,172 | +55,555 | 2.53 | 3.38 | +0.85 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 50,027 | +50,027 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 45,668 | +45,668 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 0 | 40,098 | +40,098 | 0.00 | 0.30 | +0.30 | buy |
| ORBIMED ADVISORS LLC | 0 | 40,000 | +40,000 | 0.00 | 0.06 | +0.06 | buy |
| STATE STREET CORP | 77,278 | 108,239 | +30,961 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 3,500 | 33,900 | +30,400 | 0.02 | 0.15 | +0.13 | buy |
| Walleye Capital LLC | 25,826 | 53,706 | +27,880 | 0.01 | 0.02 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 84,477 | 111,996 | +27,519 | 4.48 | 5.81 | +1.34 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 103,013 | 130,013 | +27,000 | 0.13 | 0.16 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 48,547 | 74,369 | +25,822 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 63,546 | 88,716 | +25,170 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 25,570 | 37,378 | +11,808 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 3,917 | 15,445 | +11,528 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 11,188 | +11,188 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 11,000 | +11,000 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 9,189 | +9,189 | 0.00 | 0.08 | +0.08 | buy |
| Trexquant Investment LP | 0 | 7,451 | +7,451 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 159,421 | 166,647 | +7,226 | 1.61 | 1.74 | +0.13 | buy |
| Quadrature Capital Ltd | 0 | 6,498 | +6,498 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 33,407 | 38,407 | +5,000 | 0.42 | 0.63 | +0.21 | buy |
| DnB Asset Management AS | 0 | 4,441 | +4,441 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 15,075 | 19,422 | +4,347 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 81,883 | 86,083 | +4,200 | 1.06 | 0.91 | -0.15 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 47,490 | 51,290 | +3,800 | 0.09 | 0.09 | -0.01 | buy |
| Bank of New York Mellon Corp | 9,989 | 13,253 | +3,264 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,465 | 15,318 | +2,853 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 9,944 | 12,613 | +2,669 | 0.13 | 0.17 | +0.04 | buy |
| Nuveen, LLC | 5,987 | 8,329 | +2,342 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 2,310 | +2,310 | 0.00 | 0.07 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,830 | 4,947 | +2,117 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 4,198 | 6,296 | +2,098 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 2,045 | +2,045 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,259 | 6,258 | +1,999 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 5,936 | 7,762 | +1,826 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 900 | 2,700 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,516 | 3,877 | +1,361 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 2,918 | 3,911 | +993 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,323 | 3,260 | +937 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 5,645 | 6,495 | +850 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 132,122 | 132,764 | +642 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 1,505 | 2,036 | +531 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 2,897 | 3,129 | +232 | 0.01 | 0.01 | +0.00 | buy |
| NewEdge Advisors, LLC | 50 | 250 | +200 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 114 | 297 | +183 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 310 | 380 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 547 | 616 | +69 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 30 | 45 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| TWIN PEAKS WEALTH ADVISORS, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 470 | 470 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 1,059,331 | 1,059,331 | 0 | 4.69 | 3.90 | -0.79 | hold |
| SBI Securities Co., Ltd. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,600 | 2,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,781 | 3,781 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 39 | 0 | -39 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 934 | 882 | -52 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 159 | 0 | -159 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,111 | 819 | -292 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,082 | 597 | -485 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 13,813 | 13,280 | -533 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 2,601 | 0 | -2,601 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 21,730 | 19,127 | -2,603 | 0.39 | 0.35 | -0.04 | sell |
| JANE STREET GROUP, LLC | 9,018 | 6,400 | -2,618 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 5,523 | 2,532 | -2,991 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 4,600 | 0 | -4,600 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 9,660 | 3,077 | -6,583 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 30,211 | 13,244 | -16,967 | 0.01 | 0.01 | -0.00 | sell |
| MPM BioImpact LLC | 230,147 | 212,175 | -17,972 | 2.06 | 1.20 | -0.86 | sell |
| Commodore Capital LP | 18,851 | 0 | -18,851 | 0.10 | 0.00 | -0.10 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 25,676 | 1,571 | -24,105 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 47,278 | 13,311 | -33,967 | 1.98 | 0.69 | -1.28 | sell |
| PERCEPTIVE ADVISORS LLC | 449,290 | 377,544 | -71,746 | 0.64 | 0.54 | -0.10 | sell |
| STEMPOINT CAPITAL LP | 97,340 | 0 | -97,340 | 1.30 | 0.00 | -1.30 | sell |
| MILLENNIUM MANAGEMENT LLC | 194,437 | 52,832 | -141,605 | 0.01 | 0.00 | -0.01 | sell |