| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 1,059,331 | 900,000 | -159,331 | 3.90 | 3.24 | -0.66 | sell |
| BlackRock, Inc. | 621,933 | 686,184 | +64,251 | 0.00 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 557,172 | 557,172 | 0 | 3.38 | 3.57 | +0.19 | hold |
| Vestal Point Capital, LP | 492,319 | 545,000 | +52,681 | 1.00 | 0.89 | -0.11 | buy |
| BRAIDWELL LP | 539,708 | 483,822 | -55,886 | 1.31 | 1.26 | -0.06 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 432,515 | 433,377 | +862 | 0.23 | 0.18 | -0.06 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 297,158 | 345,053 | +47,895 | 0.04 | 0.04 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 495,743 | 335,000 | -160,743 | 0.06 | 0.03 | -0.02 | sell |
| Point72 Asset Management, L.P. | 0 | 327,416 | +327,416 | 0.00 | 0.04 | +0.04 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 283,000 | 283,000 | 0 | 0.24 | 0.21 | -0.04 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 265,000 | 265,000 | 0 | 0.20 | 0.16 | -0.04 | hold |
| Parkman Healthcare Partners LLC | 40,098 | 205,053 | +164,955 | 0.30 | 1.48 | +1.18 | buy |
| MPM BioImpact LLC | 212,175 | 202,114 | -10,061 | 1.20 | 0.87 | -0.33 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 136,677 | 171,315 | +34,638 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 74,369 | 133,689 | +59,320 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 130,013 | 130,013 | 0 | 0.16 | 0.12 | -0.03 | hold |
| STATE STREET CORP | 108,239 | 122,178 | +13,939 | 0.00 | 0.00 | -0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 120,000 | 120,000 | 0 | 0.59 | 0.34 | -0.25 | hold |
| GREAT POINT PARTNERS LLC | 220,000 | 109,603 | -110,397 | 3.93 | 1.81 | -2.12 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 88,716 | 104,146 | +15,430 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 40,000 | 93,000 | +53,000 | 0.06 | 0.12 | +0.06 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 111,996 | 92,745 | -19,251 | 5.81 | 4.54 | -1.28 | sell |
| Ikarian Capital, LLC | 166,647 | 88,951 | -77,696 | 1.74 | 1.02 | -0.72 | sell |
| Sio Capital Management, LLC | 86,083 | 73,952 | -12,131 | 0.91 | 0.89 | -0.02 | sell |
| Trexquant Investment LP | 7,451 | 70,615 | +63,164 | 0.00 | 0.03 | +0.03 | buy |
| B Group, Inc. | 67,500 | 67,500 | 0 | 3.65 | 2.69 | -0.96 | hold |
| MILLENNIUM MANAGEMENT LLC | 52,832 | 66,740 | +13,908 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 66,533 | +66,533 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 13,244 | 66,277 | +53,033 | 0.01 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 53,706 | 66,106 | +12,400 | 0.02 | 0.02 | -0.00 | buy |
| Woodline Partners LP | 45,668 | 45,668 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHERN TRUST CORP | 37,378 | 42,466 | +5,088 | 0.00 | 0.00 | -0.00 | buy |
| Artia Global Partners LP | 38,407 | 38,407 | 0 | 0.63 | 0.51 | -0.12 | hold |
| AMERIPRISE FINANCIAL INC | 50,027 | 37,902 | -12,125 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 35,747 | +35,747 | 0.00 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 13,311 | 30,456 | +17,145 | 0.69 | 1.35 | +0.66 | buy |
| ADAR1 Capital Management, LLC | 33,900 | 30,300 | -3,600 | 0.15 | 0.10 | -0.05 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 51,290 | 27,870 | -23,420 | 0.09 | 0.04 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 19,422 | 26,966 | +7,544 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 12,613 | 24,274 | +11,661 | 0.17 | 0.21 | +0.04 | buy |
| Aquatic Capital Management LLC | 2,045 | 20,831 | +18,786 | 0.00 | 0.05 | +0.05 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 19,127 | 19,127 | 0 | 0.35 | 0.33 | -0.02 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 18,032 | +18,032 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,318 | 18,032 | +2,714 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 8,329 | 16,889 | +8,560 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 13,280 | 15,536 | +2,256 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 13,253 | 14,902 | +1,649 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 10,110 | +10,110 | 0.00 | 0.44 | +0.44 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 9,606 | +9,606 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 7,762 | 8,733 | +971 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 8,291 | +8,291 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 8,020 | +8,020 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 819 | 7,851 | +7,032 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,258 | 7,808 | +1,550 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 7,199 | +7,199 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,495 | 6,895 | +400 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 2,532 | 6,761 | +4,229 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 6,400 | 6,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,947 | 6,167 | +1,220 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,781 | 6,091 | +2,310 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 5,680 | +5,680 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 5,412 | +5,412 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 4,441 | 4,822 | +381 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 3,877 | 4,778 | +901 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 3,911 | 4,511 | +600 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 6,296 | 4,016 | -2,280 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 297 | 3,612 | +3,315 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,260 | 3,412 | +152 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 2,700 | 3,300 | +600 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,077 | 3,256 | +179 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,600 | 2,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,036 | 2,036 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 882 | 1,903 | +1,021 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,571 | 1,234 | -337 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 1,201 | +1,201 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 597 | 1,011 | +414 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 616 | 718 | +102 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 470 | 672 | +202 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 500 | 600 | +100 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 479 | +479 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 209 | +209 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 138 | +138 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 380 | 98 | -282 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 3 | 48 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 45 | 26 | -19 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 33 | 20 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SJS Investment Consulting Inc. | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 15,445 | 0 | -15,445 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 377,544 | 0 | -377,544 | 0.54 | 0.00 | -0.54 | sell |
| Informed Momentum Co LLC | 9,189 | 0 | -9,189 | 0.08 | 0.00 | -0.08 | sell |
| Virtu Financial LLC | 3,129 | 0 | -3,129 | 0.01 | 0.00 | -0.01 | sell |
| NewEdge Advisors, LLC | 250 | 0 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 6,498 | 0 | -6,498 | 0.01 | 0.00 | -0.01 | sell |
| Global Retirement Partners, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |