| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 269,641 | +269,641 | 0.00 | 0.14 | +0.14 | buy |
| MPM BioImpact LLC | 0 | 230,147 | +230,147 | 0.00 | 2.06 | +2.06 | buy |
| BlackRock, Inc. | 234,118 | 394,043 | +159,925 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 15,431 | 159,421 | +143,990 | 0.19 | 1.61 | +1.42 | buy |
| MILLENNIUM MANAGEMENT LLC | 76,681 | 194,437 | +117,756 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 103,013 | +103,013 | 0.00 | 0.13 | +0.13 | buy |
| STEMPOINT CAPITAL LP | 0 | 97,340 | +97,340 | 0.00 | 1.30 | +1.30 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.30 | +0.30 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 48,547 | +48,547 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 186,922 | 225,412 | +38,490 | 0.02 | 0.03 | +0.01 | buy |
| Artia Global Partners LP | 0 | 33,407 | +33,407 | 0.00 | 0.42 | +0.42 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,796 | 25,676 | +20,880 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 303,685 | 324,358 | +20,673 | 0.55 | 0.81 | +0.26 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 28,119 | 47,490 | +19,371 | 0.04 | 0.09 | +0.05 | buy |
| UBS Group AG | 0 | 13,813 | +13,813 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 13,688 | +13,688 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,145,660 | 1,155,995 | +10,335 | 0.03 | 0.04 | +0.01 | buy |
| STATE STREET CORP | 68,388 | 77,278 | +8,890 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 7,037 | 15,075 | +8,038 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 57,899 | 63,546 | +5,647 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 4,600 | +4,600 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 4,198 | +4,198 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 3,917 | +3,917 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 619 | 4,259 | +3,640 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 3,500 | +3,500 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 45,103 | 48,576 | +3,473 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 6,581 | 9,660 | +3,079 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 2,897 | +2,897 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 2,830 | +2,830 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 2,826 | 5,523 | +2,697 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,604 | 12,465 | +861 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 271 | 1,082 | +811 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 651 | 1,111 | +460 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,048 | 2,323 | +275 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 513 | 547 | +34 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 288 | 310 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 11 | 30 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 1,503 | 1,505 | +2 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 157 | 159 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 470 | 470 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 395,743 | 395,743 | 0 | 0.04 | 0.05 | +0.01 | hold |
| PERCEPTIVE ADVISORS LLC | 449,290 | 449,290 | 0 | 0.79 | 0.64 | -0.15 | hold |
| LPL Financial LLC | 5,645 | 5,645 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 2,918 | 2,918 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cormorant Asset Management, LP | 1,059,331 | 1,059,331 | 0 | 4.43 | 4.69 | +0.25 | hold |
| Vivo Capital, LLC | 501,617 | 501,617 | 0 | 2.45 | 2.53 | +0.08 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,600 | 2,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 900 | 900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,781 | 3,781 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 951 | 934 | -17 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 56 | 5 | -51 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 195 | 114 | -81 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 10,072 | 9,989 | -83 | 0.00 | 0.00 | +0.00 | sell |
| Global Retirement Partners, LLC | 200 | 100 | -100 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 84,875 | 84,477 | -398 | 5.32 | 4.48 | -0.84 | sell |
| RHUMBLINE ADVISERS | 6,576 | 5,936 | -640 | 0.00 | 0.00 | +0.00 | sell |
| Gordian Capital Singapore Pte Ltd | 1,200 | 0 | -1,200 | 0.10 | 0.00 | -0.10 | sell |
| NORTHERN TRUST CORP | 27,213 | 25,570 | -1,643 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 5,265 | 2,516 | -2,749 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 3,500 | 0 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorShares Investments LLC | 13,709 | 9,944 | -3,765 | 0.14 | 0.13 | -0.01 | sell |
| SUMMIT WEALTH GROUP LLC / CO | 6,149 | 0 | -6,149 | 0.05 | 0.00 | -0.05 | sell |
| CITADEL ADVISORS LLC | 6,476 | 0 | -6,476 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 12,487 | 5,987 | -6,500 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 28,308 | 21,730 | -6,578 | 0.11 | 0.39 | +0.28 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 53,950 | 47,278 | -6,672 | 3.22 | 1.98 | -1.25 | sell |
| JANE STREET GROUP, LLC | 15,903 | 9,018 | -6,885 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 10,711 | 2,601 | -8,110 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 66,606 | 30,211 | -36,395 | 0.03 | 0.01 | -0.02 | sell |
| Walleye Capital LLC | 72,754 | 25,826 | -46,928 | 0.04 | 0.01 | -0.02 | sell |
| MORGAN STANLEY | 192,866 | 132,122 | -60,744 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 105,020 | 0 | -105,020 | 0.01 | 0.00 | -0.01 | sell |
| Sio Capital Management, LLC | 190,764 | 81,883 | -108,881 | 2.93 | 1.06 | -1.87 | sell |
| Commodore Capital LP | 500,000 | 18,851 | -481,149 | 1.48 | 0.10 | -1.38 | sell |