| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,168,970 | 4,168,970 | 0 | 7.14 | 10.77 | +3.63 | hold |
| FMR LLC | 1,792,909 | 3,204,981 | +1,412,072 | 0.01 | 0.02 | +0.01 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 2,401,868 | 2,401,868 | 0 | 16.57 | 28.42 | +11.85 | hold |
| Deep Track Capital, LP | 500,000 | 2,000,000 | +1,500,000 | 0.65 | 3.62 | +2.97 | buy |
| CITADEL ADVISORS LLC | 1,825,672 | 1,877,775 | +52,103 | 0.08 | 0.13 | +0.05 | buy |
| Siren, L.L.C. | 1,505,374 | 1,655,374 | +150,000 | 2.64 | 4.13 | +1.50 | buy |
| BlackRock, Inc. | 282,611 | 1,593,791 | +1,311,180 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 1,690,555 | 1,561,494 | -129,061 | 0.30 | 0.55 | +0.25 | sell |
| JPMORGAN CHASE & CO | 976,166 | 1,165,584 | +189,418 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 1,054,660 | 1,096,642 | +41,982 | 0.11 | 0.19 | +0.08 | buy |
| D. E. Shaw & Co., Inc. | 134,219 | 1,013,643 | +879,424 | 0.01 | 0.08 | +0.07 | buy |
| MAVERICK CAPITAL LTD | 0 | 789,980 | +789,980 | 0.00 | 0.88 | +0.88 | buy |
| JENNISON ASSOCIATES LLC | 141,781 | 748,678 | +606,897 | 0.01 | 0.06 | +0.05 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 731,149 | 731,149 | 0 | 5.78 | 9.14 | +3.36 | hold |
| UBS Group AG | 347,075 | 670,727 | +323,652 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 654,601 | 585,560 | -69,041 | 0.04 | 0.06 | +0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,100,000 | 549,706 | -550,294 | 0.11 | 0.09 | -0.01 | sell |
| STATE STREET CORP | 74,400 | 544,369 | +469,969 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 178,206 | 508,067 | +329,861 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 500,646 | 501,590 | +944 | 0.12 | 0.19 | +0.07 | buy |
| Bank of New York Mellon Corp | 3,668 | 346,585 | +342,917 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 294,117 | 294,117 | 0 | 0.02 | 0.03 | +0.01 | hold |
| EMERALD ADVISERS, LLC | 132,536 | 288,370 | +155,834 | 0.26 | 0.83 | +0.57 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 254,876 | +254,876 | 0.00 | 0.29 | +0.29 | buy |
| BAMCO INC /NY/ | 59,668 | 229,581 | +169,913 | 0.01 | 0.04 | +0.03 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 109,283 | 209,924 | +100,641 | 0.33 | 0.91 | +0.57 | buy |
| Logos Global Management LP | 25,000 | 180,000 | +155,000 | 0.08 | 0.95 | +0.87 | buy |
| NORTHERN TRUST CORP | 34,537 | 178,112 | +143,575 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 172,201 | +172,201 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 98,009 | 172,201 | +74,192 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 532,906 | 168,934 | -363,972 | 0.07 | 0.04 | -0.03 | sell |
| AMERIPRISE FINANCIAL INC | 514,035 | 150,560 | -363,475 | 0.01 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 73,315 | 148,993 | +75,678 | 0.23 | 0.98 | +0.75 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 147,841 | +147,841 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 150,000 | 127,868 | -22,132 | 0.02 | 0.03 | +0.01 | sell |
| SEVEN GRAND MANAGERS, LLC | 74,750 | 125,000 | +50,250 | 0.32 | 0.62 | +0.30 | buy |
| MASTERS CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.93 | 1.73 | +0.80 | hold |
| MYDA Advisors LLC | 120,000 | 100,000 | -20,000 | 1.79 | 2.99 | +1.20 | sell |
| Affinity Asset Advisors, LLC | 70,000 | 100,000 | +30,000 | 0.26 | 0.60 | +0.34 | buy |
| FRANKLIN RESOURCES INC | 200,000 | 96,058 | -103,942 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 95,000 | +95,000 | 0.00 | 1.30 | +1.30 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 94,864 | +94,864 | 0.00 | 0.12 | +0.12 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 81,852 | +81,852 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 51,690 | 75,876 | +24,186 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 477,833 | 68,531 | -409,302 | 0.01 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 61,521 | +61,521 | 0.00 | 0.02 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 19,775 | 54,493 | +34,718 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 65,675 | 52,345 | -13,330 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 123,220 | 50,008 | -73,212 | 0.01 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 0 | 47,894 | +47,894 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 173,582 | 45,856 | -127,726 | 2.29 | 1.06 | -1.23 | sell |
| CenterBook Partners LP | 0 | 42,357 | +42,357 | 0.00 | 0.26 | +0.26 | buy |
| ALPS ADVISORS INC | 0 | 42,206 | +42,206 | 0.00 | 0.02 | +0.02 | buy |
| Cinctive Capital Management LP | 0 | 41,274 | +41,274 | 0.00 | 0.20 | +0.20 | buy |
| F/m Investments LLC | 0 | 35,967 | +35,967 | 0.00 | 0.22 | +0.22 | buy |
| SG Americas Securities, LLC | 0 | 35,266 | +35,266 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 31,300 | +31,300 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 31,000 | +31,000 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 30,168 | +30,168 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 0 | 27,474 | +27,474 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 30,082 | 26,967 | -3,115 | 0.02 | 0.05 | +0.03 | sell |
| Centiva Capital, LP | 20,000 | 25,817 | +5,817 | 0.06 | 0.11 | +0.05 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 25,492 | +25,492 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.13 | +0.13 | buy |
| FIFTH THIRD BANCORP | 0 | 21,690 | +21,690 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 21,068 | +21,068 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 19,356 | +19,356 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 168,975 | 19,300 | -149,675 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 18,000 | 19,000 | +1,000 | 0.16 | 0.26 | +0.10 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 18,114 | +18,114 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 3,900 | 17,532 | +13,632 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 17,039 | +17,039 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 7,105 | 15,480 | +8,375 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 15,118 | +15,118 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 36,911 | 14,706 | -22,205 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 0 | 14,424 | +14,424 | 0.00 | 0.05 | +0.05 | buy |
| FORMULA GROWTH LTD | 14,000 | 13,923 | -77 | 0.40 | 0.60 | +0.20 | sell |
| CITIGROUP INC | 10,691 | 13,875 | +3,184 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 13,532 | +13,532 | 0.00 | 0.15 | +0.15 | buy |
| MetLife Investment Management, LLC | 0 | 12,740 | +12,740 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 12,004 | +12,004 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 12,000 | +12,000 | 0.00 | 0.15 | +0.15 | buy |
| XTX Topco Ltd | 11,510 | 11,897 | +387 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 10,506 | +10,506 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 5,000 | 10,000 | +5,000 | 0.01 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 9,983 | +9,983 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 8,900 | +8,900 | 0.00 | 0.03 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 8,566 | +8,566 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 8,537 | +8,537 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 8,446 | +8,446 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 7,700 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 5,000 | 7,360 | +2,360 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 6,901 | +6,901 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 6,422 | +6,422 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 6,414 | +6,414 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 5,815 | +5,815 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 5,202 | +5,202 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 5,000 | 5,000 | 0 | 0.02 | 0.02 | +0.01 | hold |
| State of New Jersey Common Pension Fund D | 0 | 4,994 | +4,994 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 4,627 | +4,627 | 0.00 | 0.00 | +0.00 | buy |