| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 722,020 | +722,020 | 0.00 | 1.89 | +1.89 | buy |
| Cormorant Asset Management, LP | 0 | 306,222 | +306,222 | 0.00 | 0.49 | +0.49 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 146,565 | +146,565 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 133,506 | +133,506 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 132,873 | +132,873 | 0.00 | 0.81 | +0.81 | buy |
| Caligan Partners LP | 0 | 126,002 | +126,002 | 0.00 | 0.28 | +0.28 | buy |
| MARSHALL WACE, LLP | 0 | 65,730 | +65,730 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 61,568 | +61,568 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 58,001 | +58,001 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 34,549 | +34,549 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 33,025 | +33,025 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 30,000 | +30,000 | 0.00 | 0.05 | +0.05 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 26,124 | +26,124 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 11,516 | 32,041 | +20,525 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 20,333 | +20,333 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 18,337 | +18,337 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 16,205 | +16,205 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 9,501 | +9,501 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 8,872 | +8,872 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,496 | +1,496 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9 | 9 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Catalio Capital Management, LP | 14,718 | 14,718 | 0 | 0.03 | 0.10 | +0.07 | hold |
| BNP PARIBAS | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 294 | 0 | -294 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 21,351 | 6,351 | -15,000 | 0.03 | 0.03 | -0.00 | sell |