| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 34,549 | 2,020,103 | +1,985,554 | 0.03 | 1.06 | +1.03 | buy |
| Avoro Capital Advisors LLC | 0 | 1,444,039 | +1,444,039 | 0.00 | 0.32 | +0.32 | buy |
| BAKER BROS. ADVISORS LP | 0 | 1,286,411 | +1,286,411 | 0.00 | 0.16 | +0.16 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 16,205 | 1,042,198 | +1,025,993 | 0.00 | 0.05 | +0.05 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 722,020 | +722,020 | 0.00 | 0.16 | +0.16 | buy |
| Cormorant Asset Management, LP | 306,222 | 1,028,242 | +722,020 | 0.49 | 0.39 | -0.09 | buy |
| Fairmount Funds Management LLC | 0 | 722,020 | +722,020 | 0.00 | 1.19 | +1.19 | buy |
| Logos Global Management LP | 30,000 | 722,020 | +692,020 | 0.05 | 0.78 | +0.73 | buy |
| B Group, Inc. | 0 | 610,169 | +610,169 | 0.00 | 8.66 | +8.66 | buy |
| Caligan Partners LP | 126,002 | 629,467 | +503,465 | 0.28 | 0.76 | +0.48 | buy |
| Octagon Capital Advisors LP | 0 | 361,010 | +361,010 | 0.00 | 0.83 | +0.83 | buy |
| ADAR1 Capital Management, LLC | 0 | 361,010 | +361,010 | 0.00 | 0.42 | +0.42 | buy |
| FRANKLIN RESOURCES INC | 133,506 | 494,516 | +361,010 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 180,505 | +180,505 | 0.00 | 0.34 | +0.34 | buy |
| Patient Square Capital LP | 0 | 175,050 | +175,050 | 0.00 | 0.68 | +0.68 | buy |
| Alyeska Investment Group, L.P. | 0 | 144,404 | +144,404 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 144,404 | +144,404 | 0.00 | 0.18 | +0.18 | buy |
| MARSHALL WACE, LLP | 65,730 | 206,508 | +140,778 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 0 | 111,343 | +111,343 | 0.00 | 0.24 | +0.24 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 26,124 | 133,643 | +107,519 | 0.02 | 0.06 | +0.04 | buy |
| Richmond Investment Services, LLC | 0 | 79,731 | +79,731 | 0.00 | 0.63 | +0.63 | buy |
| Ikarian Capital, LLC | 6,351 | 35,386 | +29,035 | 0.03 | 0.14 | +0.12 | buy |
| UBS Group AG | 0 | 21,541 | +21,541 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 14,175 | +14,175 | 0.00 | 0.22 | +0.22 | buy |
| BARCLAYS PLC | 0 | 12,412 | +12,412 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 8,872 | 20,117 | +11,245 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 9,608 | +9,608 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 9,501 | 14,616 | +5,115 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 3,600 | +3,600 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 0 | 3,402 | +3,402 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9 | 113 | +104 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 722,020 | 722,020 | 0 | 1.89 | 1.65 | -0.24 | hold |
| SBI Securities Co., Ltd. | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalio Capital Management, LP | 14,718 | 14,718 | 0 | 0.10 | 0.07 | -0.03 | hold |
| Tower Research Capital LLC (TRC) | 1,496 | 650 | -846 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 32,041 | 20,416 | -11,625 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 18,337 | 0 | -18,337 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 20,333 | 0 | -20,333 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 33,025 | 0 | -33,025 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 58,001 | 0 | -58,001 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 61,568 | 0 | -61,568 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 132,873 | 0 | -132,873 | 0.81 | 0.00 | -0.81 | sell |
| MILLENNIUM MANAGEMENT LLC | 146,565 | 0 | -146,565 | 0.00 | 0.00 | -0.00 | sell |