| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 1,800,000 | 9,366,783 | +7,566,783 | 0.38 | 3.87 | +3.49 | buy |
| Affinity Asset Advisors, LLC | 672,357 | 3,779,694 | +3,107,337 | 0.33 | 3.37 | +3.04 | buy |
| Anson Funds Management LP | 0 | 117,146 | +117,146 | 0.00 | 0.10 | +0.10 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 3,303,573 | 3,398,890 | +95,317 | 0.69 | 2.26 | +1.58 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 282,602 | 346,000 | +63,398 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 38,039 | +38,039 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 19,179 | +19,179 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 17,555 | +17,555 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,291 | +13,291 | 0.00 | 0.00 | +0.00 | buy |
| AXXCESS WEALTH MANAGEMENT, LLC | 16,590 | 27,126 | +10,536 | 0.00 | 0.00 | +0.00 | buy |
| Donald L. Hagan, LLC | 15,000 | 20,600 | +5,600 | 0.01 | 0.05 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 19,494 | 25,027 | +5,533 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 18,034 | 18,500 | +466 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 3,564,173 | 3,564,173 | 0 | 0.02 | 0.06 | +0.04 | hold |
| PERCEPTIVE ADVISORS LLC | 57,558,451 | 57,558,451 | 0 | 2.88 | 5.75 | +2.87 | hold |
| Casdin Capital, LLC | 206,415 | 206,415 | 0 | 0.03 | 0.09 | +0.06 | hold |
| 22NW, LP | 2,211,678 | 2,211,678 | 0 | 2.45 | 6.44 | +3.99 | hold |
| Old Well Partners, LLC | 32,200 | 32,200 | 0 | 0.04 | 0.13 | +0.09 | hold |
| Vida Ventures Advisors, LLC | 2,282,084 | 2,282,084 | 0 | 5.26 | 12.14 | +6.88 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 10,830 | 10,830 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 86 | 0 | -86 | 0.00 | 0.00 | -0.00 | sell |
| CARY STREET PARTNERS INVESTMENT ADVISORY LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 10,563 | 0 | -10,563 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 27,778 | 0 | -27,778 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 36,332 | 0 | -36,332 | 0.02 | 0.00 | -0.02 | sell |
| SG Americas Securities, LLC | 58,541 | 0 | -58,541 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 200,000 | 100,000 | -100,000 | 0.11 | 0.19 | +0.08 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 101,039 | 0 | -101,039 | 0.03 | 0.00 | -0.03 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 131,641 | 0 | -131,641 | 0.03 | 0.00 | -0.03 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,184 | 0 | -134,184 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 196,313 | 42,074 | -154,239 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 181,144 | 14,605 | -166,539 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 280,000 | 0 | -280,000 | 0.06 | 0.00 | -0.06 | sell |
| TD ASSET MANAGEMENT INC | 357,038 | 0 | -357,038 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 507,806 | 0 | -507,806 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 615,940 | 0 | -615,940 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,598,766 | 0 | -2,598,766 | 0.00 | 0.00 | -0.00 | sell |