| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GREAT POINT PARTNERS LLC | 199,348 | 600,836 | +401,488 | 1.84 | 4.87 | +3.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,722,100 | 3,916,400 | +194,300 | 1.77 | 1.75 | -0.01 | buy |
| TimesSquare Capital Management, LLC | 232,463 | 364,557 | +132,094 | 100.00 | 100.00 | 0.00 | buy |
| PFM Health Sciences, LP | 174,867 | 224,289 | +49,422 | 0.64 | 0.83 | +0.18 | buy |
| E. Ohman J:or Asset Management AB | 42,990 | 85,777 | +42,787 | 0.05 | 0.09 | +0.04 | buy |
| HighVista Strategies LLC | 69,241 | 105,907 | +36,666 | 0.77 | 1.04 | +0.27 | buy |
| J. Safra Sarasin Holding AG | 13,033 | 47,662 | +34,629 | 0.01 | 0.03 | +0.02 | buy |
| Birchview Capital, LP | 44,000 | 57,758 | +13,758 | 1.01 | 1.16 | +0.15 | buy |
| ARMISTICE CAPITAL, LLC | 298,164 | 300,000 | +1,836 | 0.21 | 0.16 | -0.06 | buy |
| Bellevue Group AG | 1,710,771 | 1,710,808 | +37 | 1.64 | 1.54 | -0.09 | buy |
| Hennion & Walsh Asset Management, Inc. | 42,878 | 42,506 | -372 | 0.06 | 0.05 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 12,663 | 11,424 | -1,239 | 0.04 | 0.03 | -0.01 | sell |
| DRW Securities, LLC | 8,795 | 7,274 | -1,521 | 0.00 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 475,335 | 468,099 | -7,236 | 0.10 | 0.09 | -0.01 | sell |
| GC Wealth Management RIA, LLC | 23,999 | 13,353 | -10,646 | 0.04 | 0.03 | -0.01 | sell |
| Rock Springs Capital Management LP | 503,585 | 427,584 | -76,001 | 1.19 | 0.90 | -0.30 | sell |
| Avoro Capital Advisors LLC | 5,888,888 | 5,723,888 | -165,000 | 2.33 | 2.21 | -0.13 | sell |