| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 0 | 5,265,000 | +5,265,000 | 0.00 | 2.65 | +2.65 | buy |
| Commodore Capital LP | 5,450,000 | 3,165,000 | -2,285,000 | 7.32 | 9.13 | +1.80 | sell |
| FMR LLC | 2,774,372 | 3,123,268 | +348,896 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 3,467,156 | 2,793,987 | -673,169 | 2.99 | 7.11 | +4.12 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 2,393,029 | +2,393,029 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,181,058 | 2,350,727 | +169,669 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,633,608 | 2,148,714 | +515,106 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,914,830 | 1,823,781 | -91,049 | 2.89 | 5.88 | +2.99 | sell |
| MORGAN STANLEY | 994,840 | 1,536,790 | +541,950 | 0.00 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 3,650,339 | 1,526,787 | -2,123,552 | 6.35 | 7.32 | +0.97 | sell |
| Holocene Advisors, LP | 0 | 1,207,380 | +1,207,380 | 0.00 | 0.19 | +0.19 | buy |
| Point72 Asset Management, L.P. | 984,324 | 1,175,148 | +190,824 | 0.05 | 0.15 | +0.10 | buy |
| Pictet Asset Management Holding SA | 1,328,540 | 1,011,550 | -316,990 | 0.02 | 0.05 | +0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 782,716 | 961,309 | +178,593 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,507,140 | 947,097 | -1,560,043 | 0.42 | 0.38 | -0.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 837,195 | +837,195 | 0.00 | 0.07 | +0.07 | buy |
| Altium Capital Management LLC | 615,000 | 710,000 | +95,000 | 6.52 | 13.67 | +7.15 | buy |
| ORBIMED ADVISORS LLC | 1,518,115 | 675,872 | -842,243 | 0.47 | 0.54 | +0.07 | sell |
| Polar Capital Holdings Plc | 725,000 | 675,000 | -50,000 | 0.07 | 0.15 | +0.08 | sell |
| SAMLYN CAPITAL, LLC | 0 | 645,501 | +645,501 | 0.00 | 0.48 | +0.48 | buy |
| DEUTSCHE BANK AG\ | 633,685 | 636,994 | +3,309 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 210,039 | 601,036 | +390,997 | 0.00 | 0.03 | +0.03 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 594,091 | +594,091 | 0.00 | 0.91 | +0.91 | buy |
| Logos Global Management LP | 0 | 575,000 | +575,000 | 0.00 | 2.61 | +2.61 | buy |
| GOLDMAN SACHS GROUP INC | 649,218 | 559,790 | -89,428 | 0.00 | 0.01 | +0.00 | sell |
| Artal Group S.A. | 0 | 506,019 | +506,019 | 0.00 | 0.56 | +0.56 | buy |
| MARSHALL WACE, LLP | 0 | 480,519 | +480,519 | 0.00 | 0.03 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 0 | 470,000 | +470,000 | 0.00 | 3.29 | +3.29 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 16,761 | 446,905 | +430,144 | 0.00 | 0.07 | +0.07 | buy |
| First Light Asset Management, LLC | 0 | 436,133 | +436,133 | 0.00 | 1.44 | +1.44 | buy |
| Avidity Partners Management LP | 0 | 383,500 | +383,500 | 0.00 | 0.59 | +0.59 | buy |
| NORTHERN TRUST CORP | 321,835 | 372,454 | +50,619 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 360,000 | +360,000 | 0.00 | 1.52 | +1.52 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,110,960 | 351,653 | -759,307 | 0.02 | 0.02 | -0.00 | sell |
| Rock Springs Capital Management LP | 0 | 341,168 | +341,168 | 0.00 | 0.37 | +0.37 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 277,956 | 338,425 | +60,469 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 31,345 | 335,564 | +304,219 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 270,362 | 307,610 | +37,248 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 382,691 | 272,078 | -110,613 | 0.02 | 0.04 | +0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 68,306 | 257,257 | +188,951 | 0.01 | 0.11 | +0.10 | buy |
| Alphabet Inc. | 301,580 | 241,264 | -60,316 | 0.22 | 0.41 | +0.20 | sell |
| LORD, ABBETT & CO. LLC | 0 | 225,581 | +225,581 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 38,483 | 200,152 | +161,669 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 170,758 | 174,783 | +4,025 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 131,318 | 155,468 | +24,150 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 200,302 | 153,932 | -46,370 | 0.13 | 0.27 | +0.14 | sell |
| CITIGROUP INC | 70,305 | 152,568 | +82,263 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 101,292 | 141,350 | +40,058 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 130,794 | +130,794 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 130,338 | +130,338 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 115,422 | 126,383 | +10,961 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 0 | 118,260 | +118,260 | 0.00 | 0.76 | +0.76 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 115,000 | +115,000 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 0 | 108,000 | +108,000 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,762 | 102,164 | +88,402 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,057 | 79,700 | +66,643 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 74,939 | +74,939 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 62,843 | +62,843 | 0.00 | 0.42 | +0.42 | buy |
| Swiss National Bank | 48,700 | 62,200 | +13,500 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 60,400 | +60,400 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 59,739 | +59,739 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 47,999 | 57,747 | +9,748 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 60,069 | 51,592 | -8,477 | 0.09 | 0.21 | +0.13 | sell |
| SECTORAL ASSET MANAGEMENT INC | 124,151 | 44,901 | -79,250 | 0.82 | 0.76 | -0.06 | sell |
| BARCLAYS PLC | 113,747 | 43,568 | -70,179 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 40,000 | +40,000 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 32,680 | 39,550 | +6,870 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 30,220 | 38,732 | +8,512 | 0.00 | 0.01 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 37,744 | +37,744 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 37,737 | +37,737 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 24,990 | 37,712 | +12,722 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 37,418 | +37,418 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 18,388 | 35,536 | +17,148 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 34,791 | +34,791 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,271 | 32,359 | +5,088 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 21,317 | 31,777 | +10,460 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 30,181 | +30,181 | 0.00 | 0.06 | +0.06 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 18,711 | 27,739 | +9,028 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 106,972 | 27,566 | -79,406 | 0.05 | 0.03 | -0.02 | sell |
| PROFUND ADVISORS LLC | 27,769 | 27,346 | -423 | 0.02 | 0.05 | +0.03 | sell |
| Cubist Systematic Strategies, LLC | 7,933 | 27,130 | +19,197 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 39,647 | 26,962 | -12,685 | 0.00 | 0.00 | +0.00 | sell |
| Artia Global Partners LP | 0 | 24,298 | +24,298 | 0.00 | 0.26 | +0.26 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,068 | 22,543 | -2,525 | 0.00 | 0.00 | +0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 22,179 | +22,179 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,219 | 20,653 | +2,434 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 20,435 | +20,435 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 20,356 | +20,356 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 20,471 | 20,196 | -275 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 16,807 | 19,764 | +2,957 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 50,922 | 17,732 | -33,190 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 447 | 16,209 | +15,762 | 0.00 | 0.00 | +0.00 | buy |
| CARNEGIE MELLON UNIVERSITY | 16,060 | 16,060 | 0 | 0.30 | 0.87 | +0.57 | hold |
| FORA Capital, LLC | 0 | 16,058 | +16,058 | 0.00 | 0.06 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 14,640 | 14,680 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,338 | +14,338 | 0.00 | 0.05 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,491 | 13,987 | -3,504 | 0.00 | 0.00 | +0.00 | sell |
| NOMURA HOLDINGS INC | 0 | 13,905 | +13,905 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 13,320 | 13,467 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 13,422 | +13,422 | 0.00 | 0.06 | +0.06 | buy |