| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 1,075,000 | 2,500,000 | +1,425,000 | 2.70 | 4.29 | +1.59 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,050,000 | +1,050,000 | 0.00 | 0.50 | +0.50 | buy |
| Kynam Capital Management, LP | 1,457,910 | 2,400,000 | +942,090 | 4.07 | 4.93 | +0.87 | buy |
| Commodore Capital LP | 1,958,600 | 2,561,782 | +603,182 | 6.07 | 4.53 | -1.54 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,377,049 | 4,754,832 | +377,783 | 0.02 | 0.01 | -0.01 | buy |
| UBS Group AG | 97,303 | 459,667 | +362,364 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 1,875,963 | 2,199,292 | +323,329 | 0.26 | 0.16 | -0.10 | buy |
| Eversept Partners, LP | 1,600,015 | 1,898,804 | +298,789 | 6.98 | 5.16 | -1.82 | buy |
| T. Rowe Price Investment Management, Inc. | 1,415,179 | 1,675,367 | +260,188 | 0.04 | 0.03 | -0.01 | buy |
| Walleye Capital LLC | 0 | 198,659 | +198,659 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 30,244 | 227,016 | +196,772 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 179,550 | +179,550 | 0.00 | 0.08 | +0.08 | buy |
| FMR LLC | 3,053,126 | 3,232,319 | +179,193 | 0.01 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 170,486 | 344,623 | +174,137 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 464,807 | 623,612 | +158,805 | 3.52 | 3.02 | -0.50 | buy |
| MPM BioImpact LLC | 257,788 | 415,719 | +157,931 | 1.55 | 1.72 | +0.17 | buy |
| CITADEL ADVISORS LLC | 54,806 | 211,795 | +156,989 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 0 | 150,207 | +150,207 | 0.00 | 1.85 | +1.85 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 150,000 | +150,000 | 0.00 | 0.20 | +0.20 | buy |
| Russell Investments Group, Ltd. | 25,272 | 152,918 | +127,646 | 0.00 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 178,283 | 300,000 | +121,717 | 0.18 | 0.19 | +0.02 | buy |
| MORGAN STANLEY | 328,515 | 440,689 | +112,174 | 0.00 | 0.00 | -0.00 | buy |
| Avoro Capital Advisors LLC | 5,610,000 | 5,701,900 | +91,900 | 3.36 | 2.14 | -1.22 | buy |
| DEUTSCHE BANK AG\ | 810,376 | 892,859 | +82,483 | 0.01 | 0.01 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 76,125 | +76,125 | 0.00 | 0.22 | +0.22 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,819 | 101,279 | +74,460 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 71,560 | +71,560 | 0.00 | 0.02 | +0.02 | buy |
| GW&K Investment Management, LLC | 186,605 | 252,240 | +65,635 | 0.07 | 0.06 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 77,648 | 134,894 | +57,246 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,026,352 | 2,083,048 | +56,696 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 3,941,486 | 3,992,537 | +51,051 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,153,325 | 1,202,809 | +49,484 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 69,724 | 116,032 | +46,308 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 44,052 | +44,052 | 0.00 | 0.05 | +0.05 | buy |
| Engineers Gate Manager LP | 0 | 42,873 | +42,873 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 41,578 | +41,578 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 21,864 | 62,777 | +40,913 | 0.01 | 0.02 | +0.01 | buy |
| Jump Financial, LLC | 0 | 37,719 | +37,719 | 0.00 | 0.01 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 73,160 | 109,281 | +36,121 | 0.42 | 0.44 | +0.01 | buy |
| Rock Springs Capital Management LP | 487,863 | 520,796 | +32,933 | 0.79 | 0.72 | -0.07 | buy |
| ALGERT GLOBAL LLC | 38,550 | 70,010 | +31,460 | 0.04 | 0.04 | +0.00 | buy |
| CITIGROUP INC | 117,484 | 142,251 | +24,767 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 5,700 | 28,348 | +22,648 | 0.16 | 0.53 | +0.37 | buy |
| TD ASSET MANAGEMENT INC | 230,558 | 252,164 | +21,606 | 0.01 | 0.01 | -0.00 | buy |
| Verition Fund Management LLC | 21,895 | 42,769 | +20,874 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 20,552 | +20,552 | 0.00 | 0.02 | +0.02 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 119,664 | 139,318 | +19,654 | 0.30 | 0.19 | -0.10 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 19,597 | +19,597 | 0.00 | 0.07 | +0.07 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 80,106 | 98,013 | +17,907 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 17,323 | +17,323 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 16,982 | +16,982 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 31,843 | 46,063 | +14,220 | 0.01 | 0.01 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,570 | +13,570 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,380 | 141,409 | +13,029 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,212 | +12,212 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 17,070 | 28,646 | +11,576 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 11,531 | 22,525 | +10,994 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,496 | +10,496 | 0.00 | 0.01 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 0 | 10,056 | +10,056 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 10,000 | +10,000 | 0.00 | 0.11 | +0.11 | buy |
| Jain Global LLC | 30,204 | 39,562 | +9,358 | 0.04 | 0.02 | -0.02 | buy |
| DnB Asset Management AS | 0 | 8,485 | +8,485 | 0.00 | 0.00 | +0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 59,004 | 66,572 | +7,568 | 0.03 | 0.02 | -0.01 | buy |
| NORGES BANK | 48,593 | 54,004 | +5,411 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 21,954 | 27,297 | +5,343 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 35,700 | 40,600 | +4,900 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 58,589 | 63,189 | +4,600 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 39,576 | 43,318 | +3,742 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 3,637 | +3,637 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 794 | 4,007 | +3,213 | 0.00 | 0.01 | +0.01 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 10,182 | 13,277 | +3,095 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28,695 | 30,905 | +2,210 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 47,809 | 49,593 | +1,784 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 141,948 | 143,665 | +1,717 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,961 | 9,533 | +1,572 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 18,018 | 19,061 | +1,043 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 47 | 1,001 | +954 | 0.00 | 0.01 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 749 | +749 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,350 | 41,080 | +730 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 17,091 | 17,643 | +552 | 0.03 | 0.02 | -0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 178 | 680 | +502 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 83,077 | 83,577 | +500 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 2,000 | 2,500 | +500 | 0.02 | 0.02 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,330 | 1,621 | +291 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 24 | 227 | +203 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 615 | 799 | +184 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 22,047 | 22,202 | +155 | 0.01 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,408 | 1,535 | +127 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,586 | 12,654 | +68 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 5 | 59 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 16 | 44 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,110 | 2,133 | +23 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 45 | 50 | +5 | 0.00 | 0.00 | -0.00 | buy |