| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 1,075,000 | 2,500,000 | +1,425,000 | 2.70 | 4.29 | +1.59 | buy |
| Kynam Capital Management, LP | 1,457,910 | 2,400,000 | +942,090 | 4.07 | 4.93 | +0.87 | buy |
| Commodore Capital LP | 1,958,600 | 2,561,782 | +603,182 | 6.07 | 4.53 | -1.54 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,377,049 | 4,754,832 | +377,783 | 0.02 | 0.01 | -0.01 | buy |
| Holocene Advisors, LP | 1,875,963 | 2,199,292 | +323,329 | 0.25 | 0.15 | -0.10 | buy |
| Eversept Partners, LP | 1,600,015 | 1,898,804 | +298,789 | 6.01 | 4.63 | -1.37 | buy |
| T. Rowe Price Investment Management, Inc. | 1,415,179 | 1,675,367 | +260,188 | 0.04 | 0.03 | -0.01 | buy |
| First Turn Management, LLC | 464,807 | 623,612 | +158,805 | 3.52 | 3.02 | -0.50 | buy |
| MPM BioImpact LLC | 257,788 | 415,719 | +157,931 | 1.55 | 1.72 | +0.17 | buy |
| ARMISTICE CAPITAL, LLC | 178,283 | 300,000 | +121,717 | 0.10 | 0.11 | +0.01 | buy |
| Avoro Capital Advisors LLC | 5,610,000 | 5,701,900 | +91,900 | 3.36 | 2.14 | -1.22 | buy |
| GW&K Investment Management, LLC | 186,605 | 252,240 | +65,635 | 0.07 | 0.06 | -0.01 | buy |
| EFG Asset Management (North America) Corp. | 73,160 | 109,281 | +36,121 | 0.42 | 0.44 | +0.01 | buy |
| Rock Springs Capital Management LP | 487,863 | 520,796 | +32,933 | 0.79 | 0.72 | -0.07 | buy |
| ALGERT GLOBAL LLC | 38,550 | 70,010 | +31,460 | 0.04 | 0.04 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 485,145 | 458,841 | +26,304 | 0.02 | 0.01 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 5,700 | 28,348 | +22,648 | 0.16 | 0.53 | +0.37 | buy |
| TD ASSET MANAGEMENT INC | 230,558 | 252,164 | +21,606 | 0.01 | 0.01 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 119,664 | 139,318 | +19,654 | 0.30 | 0.19 | -0.10 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 11,531 | 22,525 | +10,994 | 0.04 | 0.05 | 0.00 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 59,004 | 66,572 | +7,568 | 0.03 | 0.02 | -0.01 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 10,182 | 13,277 | +3,095 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 17,091 | 17,643 | +552 | 0.03 | 0.02 | -0.01 | buy |
| Quarry LP | 2,000 | 2,500 | +500 | 0.02 | 0.02 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,330 | 1,621 | +291 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,427 | 12,787 | -640 | 0.05 | 0.03 | -0.02 | sell |
| WEXFORD CAPITAL LP | 43,521 | 42,305 | -1,216 | 0.29 | 0.26 | -0.03 | sell |
| Candriam S.C.A. | 365,999 | 363,692 | -2,307 | 0.09 | 0.05 | -0.03 | sell |
| Rafferty Asset Management, LLC | 87,686 | 84,876 | -2,810 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 51,207 | 46,512 | -4,695 | 0.01 | 0.01 | -0.01 | sell |
| Avidity Partners Management LP | 100,000 | 91,000 | -9,000 | 0.42 | 0.45 | +0.03 | sell |
| Siren, L.L.C. | 758,465 | 747,216 | -11,249 | 1.42 | 1.01 | -0.40 | sell |
| Nicholas Investment Partners, LP | 106,805 | 95,402 | -11,403 | 0.40 | 0.24 | -0.16 | sell |
| Decheng Capital LLC | 49,767 | 4,495 | -45,272 | 0.45 | 0.03 | -0.42 | sell |
| Affinity Asset Advisors, LLC | 425,000 | 355,143 | -69,857 | 2.41 | 0.81 | -1.60 | sell |
| First Light Asset Management, LLC | 1,261,246 | 1,175,879 | -85,367 | 5.10 | 3.23 | -1.88 | sell |
| Cinctive Capital Management LP | 113,546 | 26,364 | -87,182 | 0.26 | 0.05 | -0.21 | sell |
| Woodline Partners LP | 1,202,466 | 1,000,849 | -201,617 | 0.34 | 0.16 | -0.19 | sell |
| ORBIMED ADVISORS LLC | 742,572 | 481,065 | -261,507 | 0.65 | 0.28 | -0.37 | sell |
| JENNISON ASSOCIATES LLC | 813,861 | 507,838 | -306,023 | 0.02 | 0.01 | -0.01 | sell |
| SAMLYN CAPITAL, LLC | 1,662,220 | 978,423 | -683,797 | 1.06 | 0.35 | -0.71 | sell |
| LORD, ABBETT & CO. LLC | 1,153,670 | 148,530 | -1,005,140 | 0.15 | 0.01 | -0.14 | sell |