| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,888,888 | 5,888,888 | 0 | 2.93 | 2.33 | -0.60 | hold |
| BlackRock, Inc. | 4,825,519 | 5,088,102 | +262,583 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,461,976 | 4,574,030 | -887,946 | 0.03 | 0.02 | -0.01 | sell |
| Deep Track Capital, LP | 2,821,135 | 4,106,067 | +1,284,932 | 3.26 | 3.41 | +0.15 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,059,695 | 3,722,100 | -337,595 | 2.64 | 1.77 | -0.87 | sell |
| Kynam Capital Management, LP | 3,433,051 | 3,398,224 | -34,827 | 11.32 | 8.68 | -2.64 | sell |
| STATE STREET CORP | 2,676,600 | 3,363,638 | +687,038 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 2,793,987 | 2,793,987 | 0 | 6.10 | 5.63 | -0.47 | hold |
| FMR LLC | 2,885,853 | 2,676,422 | -209,431 | 0.01 | 0.01 | -0.00 | sell |
| Eversept Partners, LP | 3,072,304 | 2,173,286 | -899,018 | 8.72 | 5.76 | -2.96 | sell |
| Bellevue Group AG | 1,698,152 | 1,710,771 | +12,619 | 1.63 | 1.64 | +0.01 | buy |
| Integral Health Asset Management, LLC | 1,800,000 | 1,600,000 | -200,000 | 4.62 | 3.41 | -1.21 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,444,925 | 1,570,077 | +125,152 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 550,000 | 1,368,159 | +818,159 | 1.02 | 1.54 | +0.52 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,218,657 | 1,314,242 | +95,585 | 0.02 | 0.02 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,738,385 | 1,210,725 | -527,660 | 0.14 | 0.08 | -0.05 | sell |
| GOLDMAN SACHS GROUP INC | 1,120,780 | 1,133,969 | +13,189 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,392,421 | 1,051,583 | -340,838 | 0.07 | 0.04 | -0.02 | sell |
| Woodline Partners LP | 1,000,279 | 1,001,037 | +758 | 0.20 | 0.15 | -0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 732,699 | 728,330 | -4,369 | 0.02 | 0.02 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 694,319 | 589,684 | -104,635 | 0.00 | 0.00 | -0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 371,151 | 551,493 | +180,342 | 0.20 | 0.23 | +0.03 | buy |
| Qube Research & Technologies Ltd | 378,055 | 541,799 | +163,744 | 0.03 | 0.03 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 347,426 | 532,466 | +185,040 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 518,858 | 524,562 | +5,704 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 784,742 | 523,824 | -260,918 | 1.27 | 0.70 | -0.57 | sell |
| NORTHERN TRUST CORP | 473,219 | 519,445 | +46,226 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 568,579 | 503,585 | -64,994 | 1.48 | 1.19 | -0.28 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 31,779 | 484,381 | +452,602 | 0.00 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 449,554 | 475,335 | +25,781 | 0.11 | 0.10 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 193,400 | 457,300 | +263,900 | 0.02 | 0.03 | +0.01 | buy |
| CITADEL ADVISORS LLC | 777,488 | 429,761 | -347,727 | 0.03 | 0.01 | -0.01 | sell |
| First Turn Management, LLC | 601,774 | 422,023 | -179,751 | 3.48 | 1.90 | -1.59 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 54,327 | 419,570 | +365,243 | 0.01 | 0.03 | +0.03 | buy |
| Nuveen, LLC | 227,081 | 398,602 | +171,521 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 353,500 | 369,596 | +16,096 | 0.37 | 0.32 | -0.04 | buy |
| MORGAN STANLEY | 499,665 | 368,760 | -130,905 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 72,741 | 317,351 | +244,610 | 0.04 | 0.13 | +0.09 | buy |
| First Light Asset Management, LLC | 869,676 | 313,906 | -555,770 | 3.37 | 1.13 | -2.24 | sell |
| ARMISTICE CAPITAL, LLC | 653,796 | 298,164 | -355,632 | 0.81 | 0.40 | -0.41 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 474,668 | 298,149 | -176,519 | 0.02 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 199,723 | 293,497 | +93,774 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 418,963 | 290,476 | -128,487 | 0.02 | 0.01 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 351,886 | 278,765 | -73,121 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.91 | 0.59 | -0.32 | hold |
| CITIGROUP INC | 174,255 | 249,969 | +75,714 | 0.01 | 0.01 | +0.00 | buy |
| Alphabet Inc. | 241,264 | 241,264 | 0 | 0.47 | 0.24 | -0.23 | hold |
| BARCLAYS PLC | 253,716 | 232,516 | -21,200 | 0.01 | 0.00 | -0.00 | sell |
| TimesSquare Capital Management, LLC | 252,462 | 232,463 | -19,999 | 0.19 | 0.16 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 209,951 | 210,151 | +200 | 0.02 | 0.01 | -0.01 | buy |
| Ikarian Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 1.15 | +1.15 | buy |
| GREAT POINT PARTNERS LLC | 0 | 199,348 | +199,348 | 0.00 | 1.96 | +1.96 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 202,953 | 197,769 | -5,184 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 325,564 | 193,994 | -131,570 | 0.01 | 0.01 | -0.01 | sell |
| Hudson Bay Capital Management LP | 0 | 192,439 | +192,439 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 207,289 | 187,887 | -19,402 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 169,734 | 179,354 | +9,620 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 107,690 | 174,867 | +67,177 | 0.55 | 0.74 | +0.19 | buy |
| BNP Paribas Asset Management Holding S.A. | 154,553 | 153,235 | -1,318 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 207,968 | 146,189 | -61,779 | 0.01 | 0.01 | -0.00 | sell |
| Freestone Grove Partners LP | 0 | 146,097 | +146,097 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176,684 | 121,020 | -55,664 | 0.01 | 0.01 | -0.01 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 120,600 | 120,900 | +300 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 2,600 | 118,675 | +116,075 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 124,391 | 114,991 | -9,400 | 3.11 | 2.72 | -0.39 | sell |
| WELLS FARGO & COMPANY/MN | 145,205 | 114,765 | -30,440 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 119,384 | 113,687 | -5,697 | 1.40 | 1.15 | -0.24 | sell |
| Cinctive Capital Management LP | 64,617 | 106,084 | +41,467 | 0.19 | 0.28 | +0.09 | buy |
| Rafferty Asset Management, LLC | 85,836 | 101,786 | +15,950 | 0.02 | 0.02 | +0.00 | buy |
| CenterBook Partners LP | 15,639 | 97,003 | +81,364 | 0.04 | 0.21 | +0.17 | buy |
| Nicholas Investment Partners, LP | 144,810 | 95,932 | -48,878 | 0.53 | 0.28 | -0.26 | sell |
| GW&K Investment Management, LLC | 113,753 | 89,018 | -24,735 | 0.05 | 0.03 | -0.02 | sell |
| Trexquant Investment LP | 50,055 | 86,685 | +36,630 | 0.02 | 0.03 | +0.00 | buy |
| Jump Financial, LLC | 5,993 | 81,552 | +75,559 | 0.00 | 0.05 | +0.04 | buy |
| Swiss National Bank | 75,600 | 75,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 66,511 | 74,535 | +8,024 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 0 | 69,241 | +69,241 | 0.00 | 0.77 | +0.77 | buy |
| RAYMOND JAMES FINANCIAL INC | 64,875 | 65,199 | +324 | 0.00 | 0.00 | -0.00 | buy |
| Soviero Asset Management, LP | 85,000 | 65,000 | -20,000 | 2.25 | 1.47 | -0.78 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 13,071 | 64,678 | +51,607 | 0.02 | 0.06 | +0.04 | buy |
| Capricorn Fund Managers Ltd | 0 | 64,604 | +64,604 | 0.00 | 0.41 | +0.41 | buy |
| JPMORGAN CHASE & CO | 64,107 | 63,115 | -992 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 21,233 | 59,856 | +38,623 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 89,851 | 58,714 | -31,137 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 52,392 | 58,087 | +5,695 | 0.02 | 0.01 | -0.00 | buy |
| EASTERN BANK | 56,050 | 56,050 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Man Group plc | 32,364 | 53,229 | +20,865 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 124,866 | 51,161 | -73,705 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,830 | 49,737 | +11,907 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 42,825 | 49,223 | +6,398 | 0.18 | 0.23 | +0.04 | buy |
| XTX Topco Ltd | 10,025 | 48,613 | +38,588 | 0.01 | 0.03 | +0.02 | buy |
| PROFUND ADVISORS LLC | 32,024 | 45,472 | +13,448 | 0.05 | 0.07 | +0.02 | buy |
| Birchview Capital, LP | 44,000 | 44,000 | 0 | 1.30 | 1.01 | -0.30 | hold |
| E. Ohman J:or Asset Management AB | 39,500 | 42,990 | +3,490 | 0.05 | 0.05 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 42,374 | 42,878 | +504 | 0.07 | 0.06 | -0.02 | buy |
| LMR Partners LLP | 0 | 40,804 | +40,804 | 0.00 | 0.02 | +0.02 | buy |
| Lighthouse Investment Partners, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.06 | +0.06 | buy |
| ALGERT GLOBAL LLC | 64,868 | 36,310 | -28,558 | 0.05 | 0.02 | -0.03 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,797 | 36,234 | +5,437 | 0.00 | 0.00 | -0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 35,492 | +35,492 | 0.00 | 0.00 | +0.00 | buy |