| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,265,000 | 4,309,590 | -955,410 | 2.65 | 2.08 | -0.57 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,393,029 | 3,620,135 | +1,227,106 | 0.01 | 0.02 | +0.00 | buy |
| FMR LLC | 3,123,268 | 2,801,938 | -321,330 | 0.01 | 0.01 | -0.00 | sell |
| Sofinnova Investments, Inc. | 2,793,987 | 2,793,987 | 0 | 7.11 | 6.37 | -0.74 | hold |
| VANGUARD GROUP INC | 2,148,714 | 2,524,176 | +375,462 | 0.00 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 3,165,000 | 2,475,000 | -690,000 | 9.13 | 6.11 | -3.01 | sell |
| STATE STREET CORP | 2,350,727 | 2,155,553 | -195,174 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 1,823,781 | 2,043,214 | +219,433 | 5.88 | 5.66 | -0.22 | buy |
| Holocene Advisors, LP | 1,207,380 | 1,796,077 | +588,697 | 0.19 | 0.27 | +0.08 | buy |
| Kynam Capital Management, LP | 1,526,787 | 1,543,669 | +16,882 | 7.32 | 5.85 | -1.48 | buy |
| SAMLYN CAPITAL, LLC | 645,501 | 1,231,911 | +586,410 | 0.48 | 0.77 | +0.28 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 837,195 | 1,119,000 | +281,805 | 0.07 | 0.07 | +0.01 | buy |
| First Light Asset Management, LLC | 436,133 | 1,005,723 | +569,590 | 1.44 | 3.19 | +1.75 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 961,309 | 984,442 | +23,133 | 0.00 | 0.00 | -0.00 | buy |
| Logos Global Management LP | 575,000 | 950,000 | +375,000 | 2.61 | 3.96 | +1.35 | buy |
| Woodline Partners LP | 947,097 | 948,917 | +1,820 | 0.38 | 0.33 | -0.05 | buy |
| Artal Group S.A. | 506,019 | 915,974 | +409,955 | 0.56 | 0.85 | +0.29 | buy |
| GOLDMAN SACHS GROUP INC | 559,790 | 784,568 | +224,778 | 0.01 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 594,091 | 772,675 | +178,584 | 0.91 | 1.33 | +0.41 | buy |
| Altium Capital Management LLC | 710,000 | 714,000 | +4,000 | 13.67 | 10.67 | -3.00 | buy |
| ORBIMED ADVISORS LLC | 675,872 | 675,872 | 0 | 0.54 | 0.49 | -0.05 | hold |
| Polar Capital Holdings Plc | 675,000 | 675,000 | 0 | 0.15 | 0.14 | -0.01 | hold |
| DEUTSCHE BANK AG\ | 636,994 | 635,360 | -1,634 | 0.01 | 0.01 | -0.00 | sell |
| Pictet Asset Management Holding SA | 1,011,550 | 623,649 | -387,901 | 0.05 | 0.03 | -0.02 | sell |
| MARSHALL WACE, LLP | 480,519 | 524,578 | +44,059 | 0.03 | 0.03 | -0.01 | buy |
| Integral Health Asset Management, LLC | 360,000 | 500,000 | +140,000 | 1.52 | 1.80 | +0.28 | buy |
| JENNISON ASSOCIATES LLC | 74,939 | 441,162 | +366,223 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 446,905 | 440,839 | -6,066 | 0.07 | 0.06 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 351,653 | 433,172 | +81,519 | 0.02 | 0.02 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 387,380 | +387,380 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 341,168 | 381,192 | +40,024 | 0.37 | 0.42 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 470,000 | 375,000 | -95,000 | 3.29 | 2.14 | -1.16 | sell |
| D. E. Shaw & Co., Inc. | 601,036 | 370,685 | -230,351 | 0.03 | 0.02 | -0.01 | sell |
| NORTHERN TRUST CORP | 372,454 | 365,519 | -6,935 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 338,425 | 351,088 | +12,663 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,536,790 | 305,438 | -1,231,352 | 0.01 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 225,581 | 301,817 | +76,236 | 0.03 | 0.04 | +0.00 | buy |
| Candriam S.C.A. | 108,000 | 293,760 | +185,760 | 0.03 | 0.06 | +0.03 | buy |
| FEDERATED HERMES, INC. | 0 | 290,000 | +290,000 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 288,444 | +288,444 | 0.00 | 0.08 | +0.08 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 257,257 | 255,133 | -2,124 | 0.11 | 0.09 | -0.02 | sell |
| AXA S.A. | 272,078 | 246,201 | -25,877 | 0.04 | 0.03 | -0.01 | sell |
| Alphabet Inc. | 241,264 | 241,264 | 0 | 0.41 | 0.44 | +0.03 | hold |
| Cutter Capital Management, LP | 0 | 230,000 | +230,000 | 0.00 | 2.54 | +2.54 | buy |
| First Turn Management, LLC | 118,260 | 212,944 | +94,684 | 0.76 | 1.25 | +0.49 | buy |
| BANK OF AMERICA CORP /DE/ | 200,152 | 179,912 | -20,240 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 155,468 | 165,322 | +9,854 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 141,350 | 157,481 | +16,131 | 0.01 | 0.01 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 130,338 | 154,338 | +24,000 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 35,536 | 148,011 | +112,475 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 59,739 | 147,975 | +88,236 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 115,000 | 147,800 | +32,800 | 0.01 | 0.01 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 153,932 | 136,416 | -17,516 | 0.27 | 0.20 | -0.07 | sell |
| JPMORGAN CHASE & CO | 335,564 | 133,774 | -201,790 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 174,783 | 121,756 | -53,027 | 0.03 | 0.02 | -0.01 | sell |
| Point72 Asset Management, L.P. | 1,175,148 | 119,000 | -1,056,148 | 0.15 | 0.01 | -0.13 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 130,794 | 112,639 | -18,155 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 102,164 | 103,725 | +1,561 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 79,700 | 102,037 | +22,337 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 93,176 | +93,176 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 60,400 | 74,500 | +14,100 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 126,383 | 74,462 | -51,921 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 0 | 69,767 | +69,767 | 0.00 | 0.77 | +0.77 | buy |
| Swiss National Bank | 62,200 | 69,700 | +7,500 | 0.00 | 0.00 | -0.00 | buy |
| Crestline Management, LP | 51,592 | 63,550 | +11,958 | 0.21 | 0.18 | -0.03 | buy |
| Informed Momentum Co LLC | 62,843 | 62,355 | -488 | 0.42 | 0.37 | -0.06 | sell |
| Nicholas Investment Partners, LP | 0 | 59,129 | +59,129 | 0.00 | 0.22 | +0.22 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 31,777 | 55,080 | +23,303 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 57,747 | 54,859 | -2,888 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 27,130 | 53,940 | +26,810 | 0.01 | 0.03 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 49,112 | +49,112 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 6,089 | 46,855 | +40,766 | 0.05 | 0.43 | +0.38 | buy |
| Hudson Bay Capital Management LP | 40,000 | 44,300 | +4,300 | 0.02 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 43,568 | 44,001 | +433 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,739 | 43,682 | +15,943 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 38,732 | 42,834 | +4,102 | 0.01 | 0.01 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 41,917 | +41,917 | 0.00 | 0.02 | +0.02 | buy |
| Point72 (DIFC) Ltd | 1,988 | 40,413 | +38,425 | 0.01 | 0.13 | +0.12 | buy |
| ALLIANCEBERNSTEIN L.P. | 39,550 | 39,550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 27,566 | 39,416 | +11,850 | 0.03 | 0.04 | +0.01 | buy |
| Legal & General Group Plc | 37,712 | 39,373 | +1,661 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 38,330 | +38,330 | 0.00 | 0.01 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 37,400 | +37,400 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,359 | 34,860 | +2,501 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 0 | 34,772 | +34,772 | 0.00 | 0.07 | +0.07 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,147 | 33,707 | +22,560 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 34,791 | 33,397 | -1,394 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 32,400 | +32,400 | 0.00 | 0.08 | +0.08 | buy |
| EFG Asset Management (North America) Corp. | 10,343 | 31,444 | +21,101 | 0.08 | 0.20 | +0.12 | buy |
| CAPTRUST FINANCIAL ADVISORS | 37,744 | 31,186 | -6,558 | 0.01 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,987 | 25,604 | +11,617 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 10,984 | 23,586 | +12,602 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 20,653 | 22,778 | +2,125 | 0.01 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 27,346 | 22,396 | -4,950 | 0.05 | 0.03 | -0.02 | sell |
| CITIGROUP INC | 152,568 | 21,282 | -131,286 | 0.01 | 0.00 | -0.01 | sell |
| Engineers Gate Manager LP | 0 | 19,524 | +19,524 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 307,610 | 18,756 | -288,854 | 0.00 | 0.00 | -0.00 | sell |
| Magnetar Financial LLC | 0 | 18,021 | +18,021 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 17,732 | 17,732 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALGERT GLOBAL LLC | 12,420 | 17,254 | +4,834 | 0.02 | 0.02 | -0.00 | buy |