| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,393,029 | 3,620,135 | +1,227,106 | 0.01 | 0.02 | +0.00 | buy |
| Holocene Advisors, LP | 1,207,380 | 1,796,077 | +588,697 | 0.19 | 0.27 | +0.08 | buy |
| SAMLYN CAPITAL, LLC | 645,501 | 1,231,911 | +586,410 | 0.47 | 0.74 | +0.28 | buy |
| First Light Asset Management, LLC | 436,133 | 1,005,723 | +569,590 | 1.44 | 3.19 | +1.75 | buy |
| Artal Group S.A. | 506,019 | 915,974 | +409,955 | 0.56 | 0.84 | +0.29 | buy |
| Logos Global Management LP | 575,000 | 950,000 | +375,000 | 2.61 | 3.96 | +1.35 | buy |
| JENNISON ASSOCIATES LLC | 74,939 | 441,162 | +366,223 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 837,195 | 1,119,000 | +281,805 | 0.07 | 0.07 | +0.01 | buy |
| Eversept Partners, LP | 1,823,781 | 2,043,214 | +219,433 | 5.25 | 5.06 | -0.18 | buy |
| Candriam S.C.A. | 108,000 | 293,760 | +185,760 | 0.03 | 0.06 | +0.03 | buy |
| READYSTATE ASSET MANAGEMENT LP | 594,091 | 772,675 | +178,584 | 0.91 | 1.33 | +0.41 | buy |
| Integral Health Asset Management, LLC | 360,000 | 500,000 | +140,000 | 1.52 | 1.80 | +0.28 | buy |
| First Turn Management, LLC | 118,260 | 212,944 | +94,684 | 0.76 | 1.25 | +0.49 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 351,653 | 433,172 | +81,519 | 0.02 | 0.02 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 225,581 | 301,817 | +76,236 | 0.03 | 0.04 | +0.00 | buy |
| WEXFORD CAPITAL LP | 6,089 | 46,855 | +40,766 | 0.05 | 0.43 | +0.38 | buy |
| Rock Springs Capital Management LP | 341,168 | 381,192 | +40,024 | 0.37 | 0.42 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 130,338 | 154,338 | +24,000 | 0.01 | 0.01 | -0.00 | buy |
| EFG Asset Management (North America) Corp. | 10,343 | 31,444 | +21,101 | 0.08 | 0.20 | +0.12 | buy |
| Kynam Capital Management, LP | 1,526,787 | 1,543,669 | +16,882 | 7.32 | 5.85 | -1.48 | buy |
| TWO SIGMA INVESTMENTS, LP | 141,350 | 157,481 | +16,131 | 0.02 | 0.01 | 0.00 | buy |
| Crestline Management, LP | 51,592 | 63,550 | +11,958 | 0.20 | 0.18 | -0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 27,566 | 39,416 | +11,850 | 0.09 | 0.09 | 0.00 | buy |
| PROFUND ADVISORS LLC | 27,346 | 22,396 | +4,950 | 0.05 | 0.03 | 0.00 | sell |
| ALGERT GLOBAL LLC | 12,420 | 17,254 | +4,834 | 0.02 | 0.02 | 0.00 | buy |
| Hudson Bay Capital Management LP | 40,000 | 44,300 | +4,300 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 38,732 | 42,834 | +4,102 | 0.01 | 0.01 | -0.00 | buy |
| Altium Capital Management LLC | 710,000 | 714,000 | +4,000 | 13.67 | 10.67 | -3.00 | buy |
| Belvedere Trading LLC | 2,502 | 5,279 | +2,777 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 947,097 | 948,917 | +1,820 | 0.38 | 0.33 | -0.05 | buy |
| Informed Momentum Co LLC | 62,843 | 62,355 | -488 | 0.42 | 0.37 | -0.06 | sell |
| E Fund Management Co., Ltd. | 8,260 | 7,395 | -865 | 0.02 | 0.01 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 257,257 | 255,133 | -2,124 | 0.11 | 0.09 | -0.02 | sell |
| FORA Capital, LLC | 16,058 | 12,974 | -3,084 | 0.06 | 0.06 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,886 | 2,420 | -3,466 | 0.13 | 0.04 | -0.09 | sell |
| China Universal Asset Management Co., Ltd. | 10,117 | 6,427 | -3,690 | 0.06 | 0.03 | -0.02 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 10,208 | 6,191 | -4,017 | 0.01 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 153,932 | 136,416 | -17,516 | 0.27 | 0.20 | -0.07 | sell |
| J. Goldman & Co LP | 30,181 | 6,800 | -23,381 | 0.04 | 0.01 | -0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 44,901 | 7,718 | -37,183 | 0.76 | 0.11 | -0.65 | sell |
| Rafferty Asset Management, LLC | 174,783 | 121,756 | -53,027 | 0.03 | 0.02 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 470,000 | 375,000 | -95,000 | 3.29 | 2.14 | -1.16 | sell |
| Commodore Capital LP | 3,165,000 | 2,475,000 | -690,000 | 9.13 | 6.11 | -3.01 | sell |
| Avoro Capital Advisors LLC | 5,265,000 | 4,309,590 | -955,410 | 2.65 | 2.08 | -0.57 | sell |