| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,050,000 | 3,348,117 | +2,298,117 | 0.50 | 1.43 | +0.93 | buy |
| Woodline Partners LP | 1,000,849 | 2,608,372 | +1,607,523 | 0.16 | 0.32 | +0.17 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 1,350,000 | +1,200,000 | 0.20 | 1.61 | +1.41 | buy |
| Kynam Capital Management, LP | 2,400,000 | 3,426,887 | +1,026,887 | 4.93 | 8.69 | +3.76 | buy |
| Vestal Point Capital, LP | 2,500,000 | 3,100,000 | +600,000 | 4.29 | 3.85 | -0.44 | buy |
| Avoro Capital Advisors LLC | 5,701,900 | 6,300,000 | +598,100 | 2.14 | 2.60 | +0.46 | buy |
| Eversept Partners, LP | 1,898,804 | 2,383,055 | +484,251 | 4.63 | 5.16 | +0.53 | buy |
| Tri Locum Partners LP | 150,207 | 413,114 | +262,907 | 1.85 | 2.95 | +1.10 | buy |
| Affinity Asset Advisors, LLC | 355,143 | 545,000 | +189,857 | 1.34 | 1.90 | +0.56 | buy |
| ALGERT GLOBAL LLC | 70,010 | 254,153 | +184,143 | 0.04 | 0.13 | 0.00 | buy |
| MPM BioImpact LLC | 415,719 | 563,075 | +147,356 | 1.72 | 2.30 | +0.58 | buy |
| Cinctive Capital Management LP | 26,364 | 162,083 | +135,719 | 0.05 | 0.21 | +0.16 | buy |
| Rock Springs Capital Management LP | 520,796 | 617,396 | +96,600 | 0.72 | 0.91 | +0.19 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 458,841 | 372,749 | +86,092 | 0.01 | 0.01 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 76,125 | 116,343 | +40,218 | 0.22 | 0.32 | +0.10 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 139,318 | 159,751 | +20,433 | 0.19 | 0.25 | +0.06 | buy |
| SECTORAL ASSET MANAGEMENT INC | 28,348 | 41,418 | +13,070 | 0.53 | 0.64 | +0.11 | buy |
| ALPS ADVISORS INC | 46,512 | 34,441 | +12,071 | 0.01 | 0.00 | 0.00 | sell |
| Knott David M Jr | 10,000 | 20,000 | +10,000 | 0.11 | 0.21 | +0.10 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,525 | 27,400 | +4,875 | 0.05 | 0.03 | 0.00 | buy |
| Quarry LP | 2,500 | 5,500 | +3,000 | 0.02 | 0.03 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 3,637 | 4,176 | +539 | 0.02 | 0.03 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 12,787 | 12,809 | +22 | 0.03 | 0.03 | -0.00 | buy |
| PROFUND ADVISORS LLC | 17,643 | 15,281 | -2,362 | 0.02 | 0.01 | -0.01 | sell |
| HighVista Strategies LLC | 52,197 | 40,473 | -11,724 | 0.48 | 0.35 | -0.13 | sell |
| Rafferty Asset Management, LLC | 84,876 | 72,068 | -12,808 | 0.01 | 0.01 | -0.00 | sell |
| GW&K Investment Management, LLC | 252,240 | 220,028 | -32,212 | 0.06 | 0.05 | -0.01 | sell |
| WEXFORD CAPITAL LP | 42,305 | 6,864 | -35,441 | 0.26 | 0.05 | -0.22 | sell |
| SummitTX Capital, L.P. | 128,579 | 87,653 | -40,926 | 0.13 | 0.09 | -0.04 | sell |
| TD ASSET MANAGEMENT INC | 252,164 | 200,274 | -51,890 | 0.01 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 363,692 | 296,941 | -66,751 | 0.05 | 0.04 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 300,000 | 136,000 | -164,000 | 0.11 | 0.06 | -0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,754,832 | 4,479,717 | -275,115 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 623,612 | 309,666 | -313,946 | 3.02 | 1.36 | -1.66 | sell |
| Siren, L.L.C. | 747,216 | 247,216 | -500,000 | 1.01 | 0.30 | -0.71 | sell |
| First Light Asset Management, LLC | 1,175,879 | 562,981 | -612,898 | 3.23 | 1.72 | -1.51 | sell |
| Commodore Capital LP | 2,561,782 | 800,000 | -1,761,782 | 4.53 | 1.33 | -3.20 | sell |