| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,050,000 | 3,348,117 | +2,298,117 | 0.50 | 1.43 | +0.93 | buy |
| MORGAN STANLEY | 440,689 | 2,238,252 | +1,797,563 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,000,849 | 2,608,372 | +1,607,523 | 0.16 | 0.32 | +0.17 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 1,350,000 | +1,200,000 | 0.20 | 1.61 | +1.41 | buy |
| Kynam Capital Management, LP | 2,400,000 | 3,426,887 | +1,026,887 | 4.93 | 8.69 | +3.76 | buy |
| Vestal Point Capital, LP | 2,500,000 | 3,100,000 | +600,000 | 4.29 | 3.85 | -0.44 | buy |
| Avoro Capital Advisors LLC | 5,701,900 | 6,300,000 | +598,100 | 2.14 | 2.60 | +0.46 | buy |
| Eversept Partners, LP | 1,898,804 | 2,383,055 | +484,251 | 5.16 | 5.66 | +0.50 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 401,427 | +401,427 | 0.00 | 0.39 | +0.39 | buy |
| CITADEL ADVISORS LLC | 211,795 | 562,866 | +351,071 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 377,450 | 714,428 | +336,978 | 0.01 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 298,976 | +298,976 | 0.00 | 0.05 | +0.05 | buy |
| Tri Locum Partners LP | 150,207 | 413,114 | +262,907 | 1.85 | 2.95 | +1.10 | buy |
| JPMORGAN CHASE & CO | 47,742 | 310,547 | +262,805 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 355,143 | 545,000 | +189,857 | 1.34 | 1.90 | +0.56 | buy |
| ALGERT GLOBAL LLC | 70,010 | 254,153 | +184,143 | 0.04 | 0.13 | +0.08 | buy |
| BlackRock, Inc. | 3,992,537 | 4,165,540 | +173,003 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 227,016 | 394,280 | +167,264 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 155,829 | +155,829 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 415,719 | 563,075 | +147,356 | 1.72 | 2.30 | +0.58 | buy |
| DIMENSIONAL FUND ADVISORS LP | 13,768 | 153,680 | +139,912 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 26,364 | 162,083 | +135,719 | 0.05 | 0.21 | +0.16 | buy |
| NORGES BANK | 54,004 | 188,422 | +134,418 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 89,716 | 210,877 | +121,161 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 9,551 | 129,135 | +119,584 | 0.00 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 37,719 | 145,306 | +107,587 | 0.01 | 0.04 | +0.03 | buy |
| Rock Springs Capital Management LP | 520,796 | 617,396 | +96,600 | 0.72 | 0.91 | +0.19 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,202,809 | 1,294,958 | +92,149 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 18,444 | 110,552 | +92,108 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 62,777 | 152,959 | +90,182 | 0.02 | 0.04 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 134,894 | 218,831 | +83,937 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,918,423 | 3,001,108 | +82,685 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 76,700 | +76,700 | 0.00 | 1.49 | +1.49 | buy |
| Schonfeld Strategic Advisors LLC | 76,618 | 144,825 | +68,207 | 0.01 | 0.03 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,013 | 153,098 | +55,085 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 10,496 | 57,919 | +47,423 | 0.01 | 0.06 | +0.04 | buy |
| Aquatic Capital Management LLC | 0 | 47,131 | +47,131 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 418,259 | 460,510 | +42,251 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 76,125 | 116,343 | +40,218 | 0.22 | 0.32 | +0.10 | buy |
| Squarepoint Ops LLC | 17,323 | 57,519 | +40,196 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 36,136 | +36,136 | 0.00 | 0.01 | +0.01 | buy |
| Soviero Asset Management, LP | 0 | 30,000 | +30,000 | 0.00 | 0.52 | +0.52 | buy |
| J. Safra Sarasin Holding AG | 0 | 29,567 | +29,567 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 0 | 25,860 | +25,860 | 0.00 | 0.15 | +0.15 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 25,600 | +25,600 | 0.00 | 0.06 | +0.06 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 139,318 | 159,751 | +20,433 | 0.19 | 0.25 | +0.06 | buy |
| Nebula Research & Development LLC | 0 | 19,634 | +19,634 | 0.00 | 0.04 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 424,940 | 444,456 | +19,516 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 19,388 | +19,388 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 19,000 | +19,000 | 0.00 | 0.04 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 18,997 | +18,997 | 0.00 | 0.02 | +0.02 | buy |
| Massar Capital Management, LP | 0 | 16,000 | +16,000 | 0.00 | 0.28 | +0.28 | buy |
| Bank of New York Mellon Corp | 143,665 | 159,093 | +15,428 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 15,154 | +15,154 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 20,552 | 35,326 | +14,774 | 0.02 | 0.03 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 14,096 | +14,096 | 0.00 | 0.11 | +0.11 | buy |
| Atom Investors LP | 0 | 13,789 | +13,789 | 0.00 | 0.03 | +0.03 | buy |
| GC Wealth Management RIA, LLC | 0 | 13,567 | +13,567 | 0.00 | 0.03 | +0.03 | buy |
| SECTORAL ASSET MANAGEMENT INC | 28,348 | 41,418 | +13,070 | 0.53 | 0.64 | +0.11 | buy |
| RHUMBLINE ADVISERS | 63,189 | 75,070 | +11,881 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 41,080 | 52,530 | +11,450 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 11,360 | +11,360 | 0.00 | 0.01 | +0.01 | buy |
| Perigon Wealth Management, LLC | 0 | 10,406 | +10,406 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 10,078 | +10,078 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 10,000 | 20,000 | +10,000 | 0.11 | 0.21 | +0.10 | buy |
| Belvedere Trading LLC | 0 | 6,817 | +6,817 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,533 | 16,343 | +6,810 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,525 | 27,400 | +4,875 | 0.01 | 0.02 | +0.00 | buy |
| MetLife Investment Management, LLC | 26,407 | 31,071 | +4,664 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 4,330 | +4,330 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 2,500 | 5,500 | +3,000 | 0.02 | 0.03 | +0.01 | buy |
| Handelsbanken Fonder AB | 13,800 | 16,600 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,429 | 4,186 | +2,757 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,514 | 11,870 | +2,356 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 2,169 | +2,169 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,646 | 29,539 | +893 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 49,593 | 50,418 | +825 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,905 | 31,721 | +816 | 0.00 | 0.00 | -0.00 | buy |
| NATIXIS | 0 | 620 | +620 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,639 | 5,254 | +615 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 27,297 | 27,847 | +550 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 3,637 | 4,176 | +539 | 0.02 | 0.03 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 416 | +416 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,654 | 12,995 | +341 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,133 | 2,464 | +331 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 12,688 | 12,935 | +247 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 680 | 818 | +138 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 11 | 124 | +113 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 106 | +106 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 1 | 107 | +106 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,922 | 12,026 | +104 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 4 | 104 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 50 | 124 | +74 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 36 | 110 | +74 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 45 | 110 | +65 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 345 | 397 | +52 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,787 | 12,809 | +22 | 0.03 | 0.03 | -0.00 | buy |
| GeoWealth Management, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |