| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,701,900 | 6,300,000 | +598,100 | 2.14 | 2.60 | +0.46 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,754,832 | 4,479,717 | -275,115 | 0.01 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 3,992,537 | 4,165,540 | +173,003 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 2,400,000 | 3,426,887 | +1,026,887 | 4.93 | 8.69 | +3.76 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,050,000 | 3,348,117 | +2,298,117 | 0.50 | 1.43 | +0.93 | buy |
| Vestal Point Capital, LP | 2,500,000 | 3,100,000 | +600,000 | 4.29 | 3.85 | -0.44 | buy |
| VANGUARD GROUP INC | 2,918,423 | 3,001,108 | +82,685 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 3,232,319 | 2,909,964 | -322,355 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 2,793,987 | 2,793,987 | 0 | 5.06 | 4.48 | -0.58 | hold |
| Woodline Partners LP | 1,000,849 | 2,608,372 | +1,607,523 | 0.16 | 0.32 | +0.17 | buy |
| Eversept Partners, LP | 1,898,804 | 2,383,055 | +484,251 | 5.16 | 5.66 | +0.50 | buy |
| MORGAN STANLEY | 440,689 | 2,238,252 | +1,797,563 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,083,048 | 2,017,683 | -65,365 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 1,350,000 | +1,200,000 | 0.20 | 1.61 | +1.41 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,202,809 | 1,294,958 | +92,149 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 1,150,000 | 1,150,000 | 0 | 3.06 | 2.53 | -0.53 | hold |
| Commodore Capital LP | 2,561,782 | 800,000 | -1,761,782 | 4.53 | 1.33 | -3.20 | sell |
| Pictet Asset Management Holding SA | 840,258 | 772,814 | -67,444 | 0.02 | 0.02 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 377,450 | 714,428 | +336,978 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 520,796 | 617,396 | +96,600 | 0.72 | 0.91 | +0.19 | buy |
| DEUTSCHE BANK AG\ | 892,859 | 605,013 | -287,846 | 0.01 | 0.01 | -0.00 | sell |
| MPM BioImpact LLC | 415,719 | 563,075 | +147,356 | 1.72 | 2.30 | +0.58 | buy |
| First Light Asset Management, LLC | 1,175,879 | 562,981 | -612,898 | 3.23 | 1.72 | -1.51 | sell |
| CITADEL ADVISORS LLC | 211,795 | 562,866 | +351,071 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 355,143 | 545,000 | +189,857 | 1.34 | 1.90 | +0.56 | buy |
| GOLDMAN SACHS GROUP INC | 505,918 | 504,621 | -1,297 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 418,259 | 460,510 | +42,251 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 424,940 | 444,456 | +19,516 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 627,357 | 427,939 | -199,418 | 0.02 | 0.01 | -0.01 | sell |
| Tri Locum Partners LP | 150,207 | 413,114 | +262,907 | 1.85 | 2.95 | +1.10 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 401,427 | +401,427 | 0.00 | 0.39 | +0.39 | buy |
| BANK OF AMERICA CORP /DE/ | 227,016 | 394,280 | +167,264 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 458,841 | 372,749 | -86,092 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 344,623 | 311,942 | -32,681 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 47,742 | 310,547 | +262,805 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 623,612 | 309,666 | -313,946 | 3.02 | 1.36 | -1.66 | sell |
| Hudson Bay Capital Management LP | 0 | 298,976 | +298,976 | 0.00 | 0.05 | +0.05 | buy |
| Candriam S.C.A. | 363,692 | 296,941 | -66,751 | 0.05 | 0.04 | -0.01 | sell |
| ALGERT GLOBAL LLC | 70,010 | 254,153 | +184,143 | 0.04 | 0.13 | +0.08 | buy |
| Siren, L.L.C. | 747,216 | 247,216 | -500,000 | 1.01 | 0.30 | -0.71 | sell |
| Alphabet Inc. | 241,264 | 241,264 | 0 | 0.37 | 0.27 | -0.10 | hold |
| AXA S.A. | 245,565 | 228,951 | -16,614 | 0.02 | 0.02 | -0.00 | sell |
| GW&K Investment Management, LLC | 252,240 | 220,028 | -32,212 | 0.06 | 0.05 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 134,894 | 218,831 | +83,937 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 89,716 | 210,877 | +121,161 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 252,164 | 200,274 | -51,890 | 0.01 | 0.00 | -0.00 | sell |
| NORGES BANK | 54,004 | 188,422 | +134,418 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 26,364 | 162,083 | +135,719 | 0.05 | 0.21 | +0.16 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 139,318 | 159,751 | +20,433 | 0.19 | 0.25 | +0.06 | buy |
| Bank of New York Mellon Corp | 143,665 | 159,093 | +15,428 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 155,829 | +155,829 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 13,768 | 153,680 | +139,912 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,013 | 153,098 | +55,085 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 62,777 | 152,959 | +90,182 | 0.02 | 0.04 | +0.02 | buy |
| Russell Investments Group, Ltd. | 152,918 | 147,464 | -5,454 | 0.01 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 37,719 | 145,306 | +107,587 | 0.01 | 0.04 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 76,618 | 144,825 | +68,207 | 0.01 | 0.03 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 141,409 | 139,864 | -1,545 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 300,000 | 136,000 | -164,000 | 0.19 | 0.12 | -0.07 | sell |
| TWO SIGMA INVESTMENTS, LP | 9,551 | 129,135 | +119,584 | 0.00 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 76,125 | 116,343 | +40,218 | 0.22 | 0.32 | +0.10 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 18,444 | 110,552 | +92,108 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 156,882 | 108,967 | -47,915 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 116,032 | 106,167 | -9,865 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 459,667 | 102,933 | -356,734 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 128,579 | 87,653 | -40,926 | 0.14 | 0.09 | -0.05 | sell |
| Swiss National Bank | 85,400 | 85,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 142,251 | 78,537 | -63,714 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 76,700 | +76,700 | 0.00 | 1.49 | +1.49 | buy |
| RHUMBLINE ADVISERS | 63,189 | 75,070 | +11,881 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 84,876 | 72,068 | -12,808 | 0.01 | 0.01 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 83,577 | 62,037 | -21,540 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,279 | 61,565 | -39,714 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 10,496 | 57,919 | +47,423 | 0.01 | 0.06 | +0.04 | buy |
| Squarepoint Ops LLC | 17,323 | 57,519 | +40,196 | 0.00 | 0.00 | +0.00 | buy |
| EASTERN BANK | 56,050 | 56,050 | 0 | 0.03 | 0.03 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 41,080 | 52,530 | +11,450 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 49,593 | 50,418 | +825 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 47,131 | +47,131 | 0.00 | 0.02 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 28,348 | 41,418 | +13,070 | 0.53 | 0.64 | +0.11 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,640 | 40,640 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 52,197 | 40,473 | -11,724 | 0.48 | 0.35 | -0.13 | sell |
| Quadrature Capital Ltd | 0 | 36,136 | +36,136 | 0.00 | 0.01 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 20,552 | 35,326 | +14,774 | 0.02 | 0.03 | +0.01 | buy |
| ALPS ADVISORS INC | 46,512 | 34,441 | -12,071 | 0.01 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 43,318 | 33,844 | -9,474 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,905 | 31,721 | +816 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 26,407 | 31,071 | +4,664 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,880 | 30,623 | -9,257 | 0.00 | 0.00 | -0.00 | sell |
| Soviero Asset Management, LP | 0 | 30,000 | +30,000 | 0.00 | 0.52 | +0.52 | buy |
| J. Safra Sarasin Holding AG | 0 | 29,567 | +29,567 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,646 | 29,539 | +893 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 27,297 | 27,847 | +550 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,525 | 27,400 | +4,875 | 0.01 | 0.02 | +0.00 | buy |
| Scientech Research LLC | 0 | 25,860 | +25,860 | 0.00 | 0.15 | +0.15 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 25,600 | +25,600 | 0.00 | 0.06 | +0.06 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 22,290 | 22,290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 21,735 | 21,735 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 71,560 | 20,108 | -51,452 | 0.02 | 0.01 | -0.02 | sell |
| Knott David M Jr | 10,000 | 20,000 | +10,000 | 0.11 | 0.21 | +0.10 | buy |