| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,088,102 | 5,747,760 | +659,658 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 5,888,888 | 5,723,888 | -165,000 | 2.33 | 2.21 | -0.13 | sell |
| STATE STREET CORP | 3,363,638 | 4,148,786 | +785,148 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,574,030 | 4,012,936 | -561,094 | 0.02 | 0.02 | -0.00 | sell |
| Deep Track Capital, LP | 4,106,067 | 4,000,000 | -106,067 | 3.41 | 2.53 | -0.88 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,722,100 | 3,916,400 | +194,300 | 1.77 | 1.75 | -0.01 | buy |
| Kynam Capital Management, LP | 3,398,224 | 2,890,059 | -508,165 | 8.68 | 6.85 | -1.82 | sell |
| MORGAN STANLEY | 368,760 | 2,799,459 | +2,430,699 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 2,793,987 | 2,793,987 | 0 | 5.63 | 6.40 | +0.77 | hold |
| FMR LLC | 2,676,422 | 2,774,070 | +97,648 | 0.01 | 0.01 | -0.00 | buy |
| Eversept Partners, LP | 2,173,286 | 2,212,770 | +39,484 | 5.76 | 5.18 | -0.59 | buy |
| Logos Global Management LP | 0 | 2,200,000 | +2,200,000 | 0.00 | 4.06 | +4.06 | buy |
| Integral Health Asset Management, LLC | 1,600,000 | 1,750,000 | +150,000 | 3.41 | 3.08 | -0.33 | buy |
| Bellevue Group AG | 1,710,771 | 1,710,808 | +37 | 1.64 | 1.54 | -0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,570,077 | 1,692,442 | +122,365 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,314,242 | 1,591,043 | +276,801 | 0.02 | 0.02 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,133,969 | 1,380,835 | +246,866 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 551,493 | 1,295,405 | +743,912 | 0.23 | 0.52 | +0.29 | buy |
| Pictet Asset Management Holding SA | 1,051,583 | 1,249,414 | +197,831 | 0.04 | 0.05 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 532,466 | 1,102,106 | +569,640 | 0.01 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 541,799 | 1,083,179 | +541,380 | 0.03 | 0.05 | +0.02 | buy |
| Woodline Partners LP | 1,001,037 | 1,001,037 | 0 | 0.15 | 0.13 | -0.02 | hold |
| AMERICAN CENTURY COMPANIES INC | 728,330 | 866,243 | +137,913 | 0.02 | 0.02 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 290,476 | 642,562 | +352,086 | 0.01 | 0.02 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 199,348 | 600,836 | +401,488 | 1.96 | 6.07 | +4.11 | buy |
| BANK OF AMERICA CORP /DE/ | 589,684 | 590,103 | +419 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 519,445 | 581,126 | +61,681 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 523,824 | 564,724 | +40,900 | 0.70 | 0.90 | +0.19 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 545,013 | +545,013 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 524,562 | 545,013 | +20,451 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 278,765 | 527,853 | +249,088 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 484,381 | 510,787 | +26,406 | 0.02 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 475,335 | 468,099 | -7,236 | 0.10 | 0.09 | -0.01 | sell |
| Rock Springs Capital Management LP | 503,585 | 427,584 | -76,001 | 1.19 | 0.90 | -0.30 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 419,570 | 374,951 | -44,619 | 0.03 | 0.03 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 369,596 | 369,596 | 0 | 0.32 | 0.30 | -0.02 | hold |
| TimesSquare Capital Management, LLC | 232,463 | 364,557 | +132,094 | 0.16 | 0.23 | +0.07 | buy |
| Ikarian Capital, LLC | 200,000 | 310,000 | +110,000 | 1.15 | 2.18 | +1.03 | buy |
| ARMISTICE CAPITAL, LLC | 298,164 | 300,000 | +1,836 | 0.40 | 0.36 | -0.04 | buy |
| Nuveen, LLC | 398,602 | 298,410 | -100,192 | 0.00 | 0.00 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 295,114 | +295,114 | 0.00 | 0.52 | +0.52 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 457,300 | 279,528 | -177,772 | 0.03 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 293,497 | 278,658 | -14,839 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 249,969 | 266,758 | +16,789 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 187,887 | 254,182 | +66,295 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.59 | 0.52 | -0.07 | hold |
| Alphabet Inc. | 241,264 | 241,264 | 0 | 0.24 | 0.01 | -0.23 | hold |
| BARCLAYS PLC | 232,516 | 225,118 | -7,398 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 174,867 | 224,289 | +49,422 | 0.74 | 0.84 | +0.10 | buy |
| Bank of New York Mellon Corp | 179,354 | 197,694 | +18,340 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 197,769 | 195,706 | -2,063 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 97,003 | 179,467 | +82,464 | 0.21 | 0.38 | +0.17 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,020 | 160,837 | +39,817 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 114,765 | 147,086 | +32,321 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 153,235 | 147,030 | -6,205 | 0.01 | 0.01 | -0.00 | sell |
| Jump Financial, LLC | 81,552 | 140,089 | +58,537 | 0.05 | 0.05 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 193,994 | 128,070 | -65,924 | 0.01 | 0.00 | -0.00 | sell |
| Ghisallo Capital Management LLC | 0 | 125,000 | +125,000 | 0.00 | 0.11 | +0.11 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 113,687 | 113,687 | 0 | 1.15 | 1.20 | +0.05 | hold |
| GW&K Investment Management, LLC | 89,018 | 112,722 | +23,704 | 0.03 | 0.04 | +0.01 | buy |
| FIFTH THIRD BANCORP | 35,492 | 110,303 | +74,811 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 6,440 | 108,139 | +101,699 | 0.00 | 0.06 | +0.06 | buy |
| HighVista Strategies LLC | 69,241 | 105,907 | +36,666 | 0.77 | 1.04 | +0.27 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 146,189 | 105,293 | -40,896 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 15,684 | 104,937 | +89,253 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 210,151 | 104,170 | -105,981 | 0.01 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 48,613 | 103,607 | +54,994 | 0.03 | 0.06 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 118,675 | 102,598 | -16,077 | 0.01 | 0.01 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 64,678 | 100,966 | +36,288 | 0.06 | 0.08 | +0.02 | buy |
| Exome Asset Management LLC | 114,991 | 97,276 | -17,715 | 2.72 | 2.57 | -0.15 | sell |
| ALGERT GLOBAL LLC | 36,310 | 92,250 | +55,940 | 0.02 | 0.05 | +0.02 | buy |
| Swiss National Bank | 75,600 | 85,900 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 42,990 | 85,777 | +42,787 | 0.05 | 0.09 | +0.04 | buy |
| RHUMBLINE ADVISERS | 74,535 | 79,307 | +4,772 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 65,199 | 78,337 | +13,138 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 5,500 | 74,509 | +69,009 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 101,786 | 73,469 | -28,317 | 0.02 | 0.01 | -0.01 | sell |
| ALPS ADVISORS INC | 58,087 | 72,557 | +14,470 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 68,098 | +68,098 | 0.00 | 0.08 | +0.08 | buy |
| AMERIPRISE FINANCIAL INC | 14,973 | 57,895 | +42,922 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 44,000 | 57,758 | +13,758 | 1.01 | 1.16 | +0.15 | buy |
| DIADEMA PARTNERS LP | 0 | 57,608 | +57,608 | 0.00 | 0.87 | +0.87 | buy |
| EASTERN BANK | 56,050 | 56,050 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Trexquant Investment LP | 86,685 | 54,608 | -32,077 | 0.03 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 58,714 | 50,847 | -7,867 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 63,115 | 50,780 | -12,335 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 53,229 | 50,346 | -2,883 | 0.00 | 0.00 | -0.00 | sell |
| Swedbank AB | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 51,161 | 49,346 | -1,815 | 0.00 | 0.00 | -0.00 | sell |
| Neo Ivy Capital Management | 12,167 | 48,937 | +36,770 | 0.13 | 0.48 | +0.35 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,737 | 48,357 | -1,380 | 0.00 | 0.00 | -0.00 | sell |
| J. Safra Sarasin Holding AG | 13,033 | 47,662 | +34,629 | 0.01 | 0.03 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 42,878 | 42,506 | -372 | 0.06 | 0.05 | -0.01 | sell |
| Point72 Asset Management, L.P. | 1,210,725 | 40,563 | -1,170,162 | 0.08 | 0.00 | -0.08 | sell |
| LMR Partners LLP | 40,804 | 40,000 | -804 | 0.02 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,234 | 37,844 | +1,610 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 33,805 | 37,403 | +3,598 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 45,472 | 37,062 | -8,410 | 0.07 | 0.04 | -0.02 | sell |
| Legal & General Group Plc | 33,958 | 34,998 | +1,040 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 8,456 | 32,857 | +24,401 | 0.00 | 0.01 | +0.00 | buy |