| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 6,300,000 | 6,210,000 | -90,000 | 2.60 | 2.33 | -0.26 | sell |
| BlackRock, Inc. | 4,165,540 | 4,247,190 | +81,650 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 3,426,887 | 4,027,800 | +600,913 | 8.69 | 8.71 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,479,717 | 3,666,439 | -813,278 | 0.01 | 0.01 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,348,117 | 3,641,157 | +293,040 | 1.43 | 1.62 | +0.19 | buy |
| VANGUARD GROUP INC | 3,001,108 | 3,190,653 | +189,545 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,909,964 | 2,843,131 | -66,833 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 2,383,055 | 2,807,836 | +424,781 | 5.66 | 6.25 | +0.59 | buy |
| Sofinnova Investments, Inc. | 2,793,987 | 2,793,987 | 0 | 4.48 | 4.98 | +0.50 | hold |
| STATE STREET CORP | 2,017,683 | 2,333,583 | +315,900 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,150,000 | 1,700,000 | +550,000 | 2.53 | 3.60 | +1.07 | buy |
| CITADEL ADVISORS LLC | 562,866 | 1,615,338 | +1,052,472 | 0.01 | 0.04 | +0.03 | buy |
| Pictet Asset Management Holding SA | 772,814 | 1,439,121 | +666,307 | 0.02 | 0.04 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,350,000 | 1,350,000 | 0 | 1.61 | 1.51 | -0.10 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,294,958 | 1,321,575 | +26,617 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 1,272,027 | +1,272,027 | 0.00 | 0.08 | +0.08 | buy |
| Tri Locum Partners LP | 413,114 | 1,190,207 | +777,093 | 2.95 | 7.95 | +5.00 | buy |
| Vestal Point Capital, LP | 3,100,000 | 760,000 | -2,340,000 | 3.85 | 1.00 | -2.84 | sell |
| GOLDMAN SACHS GROUP INC | 504,621 | 758,566 | +253,945 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,608,372 | 737,578 | -1,870,794 | 0.32 | 0.10 | -0.22 | sell |
| AMERICAN CENTURY COMPANIES INC | 714,428 | 708,423 | -6,005 | 0.01 | 0.01 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 372,749 | 679,992 | +307,243 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 605,013 | 633,820 | +28,807 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 617,396 | 617,396 | 0 | 0.91 | 1.05 | +0.14 | hold |
| MILLENNIUM MANAGEMENT LLC | 218,831 | 598,454 | +379,623 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 563,075 | 563,075 | 0 | 2.30 | 2.68 | +0.38 | hold |
| ARMISTICE CAPITAL, LLC | 136,000 | 536,000 | +400,000 | 0.12 | 0.49 | +0.37 | buy |
| PFM Health Sciences, LP | 0 | 513,685 | +513,685 | 0.00 | 1.27 | +1.27 | buy |
| First Light Asset Management, LLC | 562,981 | 507,097 | -55,884 | 1.72 | 1.39 | -0.33 | sell |
| BANK OF AMERICA CORP /DE/ | 394,280 | 490,472 | +96,192 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 472,739 | +472,739 | 0.00 | 0.41 | +0.41 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 444,456 | 465,809 | +21,353 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 311,942 | 461,410 | +149,468 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 460,510 | 461,260 | +750 | 0.00 | 0.00 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 450,700 | +450,700 | 0.00 | 4.40 | +4.40 | buy |
| Hudson Bay Capital Management LP | 298,976 | 440,591 | +141,615 | 0.05 | 0.08 | +0.03 | buy |
| Candriam S.C.A. | 296,941 | 427,189 | +130,248 | 0.04 | 0.06 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 427,939 | 416,376 | -11,563 | 0.01 | 0.01 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 153,680 | 360,332 | +206,652 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 309,666 | 354,529 | +44,863 | 1.36 | 1.55 | +0.19 | buy |
| Nuveen, LLC | 108,967 | 317,679 | +208,712 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 545,000 | 303,330 | -241,670 | 1.90 | 0.82 | -1.08 | sell |
| HSBC HOLDINGS PLC | 0 | 297,017 | +297,017 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 254,153 | 293,388 | +39,235 | 0.13 | 0.14 | +0.02 | buy |
| MORGAN STANLEY | 2,238,252 | 274,523 | -1,963,729 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 110,552 | 253,976 | +143,424 | 0.00 | 0.01 | +0.00 | buy |
| Alphabet Inc. | 241,264 | 241,264 | 0 | 0.27 | 0.29 | +0.02 | hold |
| BARCLAYS PLC | 210,877 | 217,593 | +6,716 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 200,274 | 210,474 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 152,959 | 208,500 | +55,541 | 0.04 | 0.06 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 129,135 | 171,659 | +42,524 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 147,464 | 163,169 | +15,705 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 102,933 | 162,075 | +59,142 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 159,093 | 161,541 | +2,448 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 159,751 | 159,751 | 0 | 0.25 | 0.30 | +0.05 | hold |
| Exome Asset Management LLC | 76,700 | 156,072 | +79,372 | 1.49 | 2.99 | +1.50 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 139,864 | 139,585 | -279 | 0.00 | 0.00 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 0 | 130,000 | +130,000 | 0.00 | 0.42 | +0.42 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 102,200 | +102,200 | 0.00 | 0.00 | +0.00 | buy |
| Soviero Asset Management, LP | 30,000 | 100,000 | +70,000 | 0.52 | 1.80 | +1.28 | buy |
| Cubist Systematic Strategies, LLC | 0 | 96,871 | +96,871 | 0.00 | 0.04 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 116,343 | 96,737 | -19,606 | 0.32 | 0.31 | -0.01 | sell |
| Cinctive Capital Management LP | 162,083 | 96,573 | -65,510 | 0.21 | 0.14 | -0.07 | sell |
| HighVista Strategies LLC | 40,473 | 91,189 | +50,716 | 0.35 | 0.65 | +0.30 | buy |
| SummitTX Capital, L.P. | 87,653 | 87,653 | 0 | 0.09 | 0.11 | +0.01 | hold |
| Rafferty Asset Management, LLC | 72,068 | 87,497 | +15,429 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 310,547 | 82,365 | -228,182 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 153,098 | 82,282 | -70,816 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 33,844 | 81,212 | +47,368 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 85,400 | 80,400 | -5,000 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 144,825 | 79,510 | -65,315 | 0.03 | 0.02 | -0.01 | sell |
| GW&K Investment Management, LLC | 220,028 | 77,065 | -142,963 | 0.05 | 0.02 | -0.03 | sell |
| RHUMBLINE ADVISERS | 75,070 | 72,959 | -2,111 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 67,193 | +67,193 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,565 | 66,607 | +5,042 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 106,167 | 58,505 | -47,662 | 0.00 | 0.00 | -0.00 | sell |
| EASTERN BANK | 56,050 | 56,050 | 0 | 0.03 | 0.03 | +0.00 | hold |
| J. Safra Sarasin Holding AG | 29,567 | 55,317 | +25,750 | 0.01 | 0.03 | +0.01 | buy |
| Jump Financial, LLC | 145,306 | 54,353 | -90,953 | 0.04 | 0.02 | -0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 52,530 | 52,591 | +61 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 50,418 | 51,263 | +845 | 0.00 | 0.00 | +0.00 | buy |
| Swedbank AB | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 25,600 | 46,551 | +20,951 | 0.06 | 0.11 | +0.05 | buy |
| Verition Fund Management LLC | 0 | 40,877 | +40,877 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 40,851 | +40,851 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,640 | 40,612 | -28 | 0.00 | 0.00 | +0.00 | sell |
| GC Wealth Management RIA, LLC | 13,567 | 38,885 | +25,318 | 0.03 | 0.04 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 35,326 | 34,936 | -390 | 0.03 | 0.03 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 18,997 | 32,286 | +13,289 | 0.02 | 0.03 | +0.02 | buy |
| SG Americas Securities, LLC | 0 | 31,345 | +31,345 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 31,071 | 31,071 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 34,441 | 30,750 | -3,691 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 27,847 | 30,632 | +2,785 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 41,418 | 30,188 | -11,230 | 0.64 | 0.54 | -0.10 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,721 | 28,383 | -3,338 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,623 | 27,844 | -2,779 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 19,388 | 26,571 | +7,183 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 20,000 | 26,000 | +6,000 | 0.21 | 0.32 | +0.10 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 18,512 | 22,739 | +4,227 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 13,789 | 22,539 | +8,750 | 0.03 | 0.05 | +0.02 | buy |