| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 1,272,027 | +1,272,027 | 0.00 | 0.08 | +0.08 | buy |
| CITADEL ADVISORS LLC | 562,866 | 1,615,338 | +1,052,472 | 0.01 | 0.04 | +0.03 | buy |
| Tri Locum Partners LP | 413,114 | 1,190,207 | +777,093 | 2.95 | 7.95 | +5.00 | buy |
| Pictet Asset Management Holding SA | 772,814 | 1,439,121 | +666,307 | 0.02 | 0.04 | +0.02 | buy |
| Kynam Capital Management, LP | 3,426,887 | 4,027,800 | +600,913 | 8.69 | 8.71 | +0.02 | buy |
| Integral Health Asset Management, LLC | 1,150,000 | 1,700,000 | +550,000 | 2.53 | 3.60 | +1.07 | buy |
| PFM Health Sciences, LP | 0 | 513,685 | +513,685 | 0.00 | 1.27 | +1.27 | buy |
| BRAIDWELL LP | 0 | 472,739 | +472,739 | 0.00 | 0.41 | +0.41 | buy |
| Capricorn Fund Managers Ltd | 0 | 450,700 | +450,700 | 0.00 | 4.40 | +4.40 | buy |
| Eversept Partners, LP | 2,383,055 | 2,807,836 | +424,781 | 5.66 | 6.25 | +0.59 | buy |
| ARMISTICE CAPITAL, LLC | 136,000 | 536,000 | +400,000 | 0.12 | 0.49 | +0.37 | buy |
| MILLENNIUM MANAGEMENT LLC | 218,831 | 598,454 | +379,623 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,017,683 | 2,333,583 | +315,900 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 372,749 | 679,992 | +307,243 | 0.01 | 0.02 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 297,017 | +297,017 | 0.00 | 0.01 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,348,117 | 3,641,157 | +293,040 | 1.43 | 1.62 | +0.19 | buy |
| GOLDMAN SACHS GROUP INC | 504,621 | 758,566 | +253,945 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 108,967 | 317,679 | +208,712 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 153,680 | 360,332 | +206,652 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,001,108 | 3,190,653 | +189,545 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 311,942 | 461,410 | +149,468 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 110,552 | 253,976 | +143,424 | 0.00 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 298,976 | 440,591 | +141,615 | 0.05 | 0.08 | +0.03 | buy |
| Candriam S.C.A. | 296,941 | 427,189 | +130,248 | 0.04 | 0.06 | +0.02 | buy |
| Rhenman & Partners Asset Management AB | 0 | 130,000 | +130,000 | 0.00 | 0.42 | +0.42 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 102,200 | +102,200 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 96,871 | +96,871 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 394,280 | 490,472 | +96,192 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,165,540 | 4,247,190 | +81,650 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 76,700 | 156,072 | +79,372 | 1.49 | 2.99 | +1.50 | buy |
| Soviero Asset Management, LP | 30,000 | 100,000 | +70,000 | 0.52 | 1.80 | +1.28 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 67,193 | +67,193 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 102,933 | 162,075 | +59,142 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 152,959 | 208,500 | +55,541 | 0.04 | 0.06 | +0.02 | buy |
| HighVista Strategies LLC | 40,473 | 91,189 | +50,716 | 0.35 | 0.65 | +0.30 | buy |
| Swedbank AB | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,844 | 81,212 | +47,368 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 309,666 | 354,529 | +44,863 | 1.36 | 1.55 | +0.19 | buy |
| TWO SIGMA INVESTMENTS, LP | 129,135 | 171,659 | +42,524 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 40,877 | +40,877 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 40,851 | +40,851 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 254,153 | 293,388 | +39,235 | 0.13 | 0.14 | +0.02 | buy |
| SG Americas Securities, LLC | 0 | 31,345 | +31,345 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 605,013 | 633,820 | +28,807 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,294,958 | 1,321,575 | +26,617 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 29,567 | 55,317 | +25,750 | 0.01 | 0.03 | +0.01 | buy |
| GC Wealth Management RIA, LLC | 13,567 | 38,885 | +25,318 | 0.03 | 0.04 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 22,138 | +22,138 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 444,456 | 465,809 | +21,353 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 25,600 | 46,551 | +20,951 | 0.06 | 0.11 | +0.05 | buy |
| Brevan Howard Capital Management LP | 0 | 19,181 | +19,181 | 0.00 | 0.01 | +0.01 | buy |
| Optimize Financial Inc | 0 | 17,544 | +17,544 | 0.00 | 0.27 | +0.27 | buy |
| Russell Investments Group, Ltd. | 147,464 | 163,169 | +15,705 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 72,068 | 87,497 | +15,429 | 0.01 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 18,997 | 32,286 | +13,289 | 0.02 | 0.03 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 13,042 | +13,042 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 11,983 | +11,983 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 10,562 | +10,562 | 0.00 | 0.75 | +0.75 | buy |
| TD ASSET MANAGEMENT INC | 200,274 | 210,474 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 9,078 | +9,078 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 13,789 | 22,539 | +8,750 | 0.03 | 0.05 | +0.02 | buy |
| Headlands Technologies LLC | 0 | 7,993 | +7,993 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 19,388 | 26,571 | +7,183 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 210,877 | 217,593 | +6,716 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 20,000 | 26,000 | +6,000 | 0.21 | 0.32 | +0.10 | buy |
| Walleye Trading LLC | 0 | 5,225 | +5,225 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,565 | 66,607 | +5,042 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 16,600 | 21,500 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 18,512 | 22,739 | +4,227 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,014 | 5,214 | +4,200 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 3,735 | +3,735 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 15,281 | 18,992 | +3,711 | 0.01 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 27,847 | 30,632 | +2,785 | 0.00 | 0.00 | +0.00 | buy |
| Perigon Wealth Management, LLC | 10,406 | 12,898 | +2,492 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 159,093 | 161,541 | +2,448 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,870 | 14,249 | +2,379 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 702 | 1,952 | +1,250 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 1,230 | +1,230 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 4,176 | 5,052 | +876 | 0.03 | 0.04 | +0.01 | buy |
| Legal & General Group Plc | 50,418 | 51,263 | +845 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 460,510 | 461,260 | +750 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 464 | +464 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 350 | +350 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 299 | +299 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 110 | 232 | +122 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 397 | 467 | +70 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 52,530 | 52,591 | +61 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 42 | +42 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 3 | 11 | +8 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 104 | 111 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 20 | 25 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,464 | 2,467 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 124 | 125 | +1 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 5 | 6 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| EASTERN BANK | 56,050 | 56,050 | 0 | 0.03 | 0.03 | +0.00 | hold |