| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 1,110,960 | +1,110,960 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 984,324 | +984,324 | 0.00 | 0.05 | +0.05 | buy |
| Polar Capital Holdings Plc | 0 | 725,000 | +725,000 | 0.00 | 0.07 | +0.07 | buy |
| Kynam Capital Management, LP | 2,956,053 | 3,650,339 | +694,286 | 6.74 | 6.35 | -0.38 | buy |
| DEUTSCHE BANK AG\ | 16,031 | 633,685 | +617,654 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,727,646 | 2,181,058 | +453,412 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,478,489 | 1,914,830 | +436,341 | 2.25 | 2.89 | +0.64 | buy |
| Altium Capital Management LLC | 333,681 | 615,000 | +281,319 | 2.65 | 6.52 | +3.87 | buy |
| GOLDMAN SACHS GROUP INC | 419,804 | 649,218 | +229,414 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 270,993 | 382,691 | +111,698 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 1,226,147 | 1,328,540 | +102,393 | 0.02 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 914,746 | 994,840 | +80,094 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 43,935 | 115,422 | +71,487 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,574,390 | 1,633,608 | +59,218 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 158,186 | 210,039 | +51,853 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 50,922 | +50,922 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 738,567 | 782,716 | +44,149 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 71,703 | 113,747 | +42,044 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 136,377 | 170,758 | +34,381 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 28,005 | +28,005 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 295,504 | 321,835 | +26,331 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 29,970 | 52,590 | +22,620 | 0.04 | 0.07 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 21,317 | +21,317 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 20,471 | +20,471 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 18,388 | +18,388 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 16,389 | +16,389 | 0.00 | 0.04 | +0.04 | buy |
| Crestline Management, LP | 45,380 | 60,069 | +14,689 | 0.07 | 0.09 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 14,640 | +14,640 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 57,390 | 70,305 | +12,915 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 267,004 | 277,956 | +10,952 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 10,790 | +10,790 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 10,430 | +10,430 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 23,061 | 31,345 | +8,284 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 7,933 | +7,933 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 7,709 | +7,709 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 6,289 | +6,289 | 0.00 | 0.06 | +0.06 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,247 | 17,491 | +6,244 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,339 | 8,295 | +5,956 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,301 | 25,068 | +5,767 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,143 | +5,143 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Middle East FZE | 0 | 4,927 | +4,927 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 23,114 | 27,769 | +4,655 | 0.02 | 0.02 | +0.00 | buy |
| Bank of New York Mellon Corp | 128,232 | 131,318 | +3,086 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 20,579 | 23,116 | +2,537 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,300 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 100,561 | 101,292 | +731 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,023 | 27,271 | +248 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 182 | +182 | 0.00 | 0.00 | +0.00 | buy |
| CARNEGIE MELLON UNIVERSITY | 16,060 | 16,060 | 0 | 0.28 | 0.30 | +0.02 | hold |
| ORBIMED ADVISORS LLC | 1,518,115 | 1,518,115 | 0 | 0.45 | 0.47 | +0.02 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,312 | 3,312 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 13,762 | 13,762 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 200,302 | 200,302 | 0 | 0.11 | 0.13 | +0.02 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,790 | 5,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HALL LAURIE J TRUSTEE | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Carlyle Group Inc. | 1,438,155 | 1,438,155 | 0 | 0.85 | 1.06 | +0.21 | hold |
| MetLife Investment Management, LLC | 18,219 | 18,219 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 48,700 | 48,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sofinnova Investments, Inc. | 3,467,156 | 3,467,156 | 0 | 3.30 | 2.99 | -0.32 | hold |
| Alphabet Inc. | 301,580 | 301,580 | 0 | 0.27 | 0.22 | -0.05 | hold |
| Russell Investments Group, Ltd. | 447 | 447 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Commodore Capital LP | 5,450,000 | 5,450,000 | 0 | 8.73 | 7.32 | -1.41 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,272 | 2,272 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 24,990 | 24,990 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 68,306 | 68,306 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 16,874 | 16,807 | -67 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 4,189 | 3,846 | -343 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 48,411 | 47,999 | -412 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 13,771 | 13,320 | -451 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,560 | 13,057 | -503 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 610 | 30 | -580 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 34,290 | 32,680 | -1,610 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 32,710 | 30,220 | -2,490 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 44,294 | 39,647 | -4,647 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 11,038 | 0 | -11,038 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 17,816 | 0 | -17,816 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 32,403 | 9,632 | -22,771 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 30,902 | 0 | -30,902 | 0.20 | 0.00 | -0.20 | sell |
| XTX Topco Ltd | 32,048 | 0 | -32,048 | 0.08 | 0.00 | -0.08 | sell |
| Tri Locum Partners LP | 43,438 | 0 | -43,438 | 0.19 | 0.00 | -0.19 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 62,322 | 18,711 | -43,611 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 69,671 | 16,761 | -52,910 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 2,562,600 | 2,507,140 | -55,460 | 0.41 | 0.42 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 95,116 | 38,483 | -56,633 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 177,991 | 106,972 | -71,019 | 0.04 | 0.05 | +0.01 | sell |
| JANE STREET GROUP, LLC | 83,025 | 0 | -83,025 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 84,506 | 0 | -84,506 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 87,200 | 0 | -87,200 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 105,000 | 0 | -105,000 | 0.35 | 0.00 | -0.35 | sell |
| Invesco Ltd. | 390,781 | 270,362 | -120,419 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 135,755 | 0 | -135,755 | 0.04 | 0.00 | -0.04 | sell |
| SECTORAL ASSET MANAGEMENT INC | 357,139 | 124,151 | -232,988 | 0.95 | 0.82 | -0.13 | sell |
| FMR LLC | 5,445,366 | 2,774,372 | -2,670,994 | 0.01 | 0.00 | -0.00 | sell |