| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 4,309,590 | 5,610,000 | +1,300,410 | 2.78 | 3.36 | +0.58 | buy |
| LORD, ABBETT & CO. LLC | 426,014 | 1,153,670 | +727,656 | 0.06 | 0.15 | +0.09 | buy |
| Integral Health Asset Management, LLC | 500,000 | 1,150,000 | +650,000 | 2.49 | 4.15 | +1.66 | buy |
| First Light Asset Management, LLC | 705,234 | 1,261,246 | +556,012 | 2.59 | 5.10 | +2.51 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,939,109 | 4,377,049 | +437,940 | 0.02 | 0.02 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 984,001 | 1,415,179 | +431,178 | 0.03 | 0.04 | +0.01 | buy |
| Logos Global Management LP | 500,000 | 875,000 | +375,000 | 2.38 | 4.33 | +1.95 | buy |
| JENNISON ASSOCIATES LLC | 447,098 | 813,861 | +366,763 | 0.01 | 0.02 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 1,096,851 | 1,437,339 | +340,488 | 1.70 | 2.11 | +0.42 | buy |
| SAMLYN CAPITAL, LLC | 1,359,227 | 1,662,220 | +302,993 | 0.91 | 1.06 | +0.15 | buy |
| Woodline Partners LP | 1,000,893 | 1,202,466 | +201,573 | 0.37 | 0.34 | -0.03 | buy |
| READYSTATE ASSET MANAGEMENT LP | 47,683 | 189,088 | +141,405 | 0.11 | 0.34 | +0.23 | buy |
| First Turn Management, LLC | 326,494 | 464,807 | +138,313 | 2.28 | 3.52 | +1.24 | buy |
| Rock Springs Capital Management LP | 383,492 | 487,863 | +104,371 | 0.55 | 0.79 | +0.23 | buy |
| Crestline Management, LP | 81,315 | 160,347 | +79,032 | 0.19 | 0.23 | +0.04 | buy |
| Candriam S.C.A. | 293,760 | 365,999 | +72,239 | 0.06 | 0.09 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 675,872 | 742,572 | +66,700 | 0.55 | 0.65 | +0.11 | buy |
| Cinctive Capital Management LP | 48,500 | 113,546 | +65,046 | 0.12 | 0.24 | +0.13 | buy |
| Cutter Capital Management, LP | 172,876 | 212,696 | +39,820 | 2.26 | 3.69 | +1.43 | buy |
| TD ASSET MANAGEMENT INC | 192,894 | 230,558 | +37,664 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 71,559 | 106,805 | +35,246 | 0.29 | 0.40 | +0.11 | buy |
| HighVista Strategies LLC | 22,010 | 52,197 | +30,187 | 0.34 | 0.82 | +0.49 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 30,880 | 59,004 | +28,124 | 0.02 | 0.03 | +0.02 | buy |
| EFG Asset Management (North America) Corp. | 45,968 | 73,160 | +27,192 | 0.34 | 0.42 | +0.08 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 31,452 | 11,531 | +19,921 | 0.11 | 0.04 | 0.00 | sell |
| ALGERT GLOBAL LLC | 23,164 | 38,550 | +15,386 | 0.03 | 0.04 | 0.00 | buy |
| Rafferty Asset Management, LLC | 78,945 | 87,686 | +8,741 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 476,713 | 485,145 | +8,432 | 0.02 | 0.02 | -0.00 | buy |
| ALPS ADVISORS INC | 44,266 | 51,207 | +6,941 | 0.01 | 0.01 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 17,101 | 22,290 | +5,189 | 5.45 | 40.55 | +35.10 | buy |
| China Universal Asset Management Co., Ltd. | 10,545 | 13,427 | +2,882 | 0.05 | 0.05 | +0.00 | buy |
| PROFUND ADVISORS LLC | 15,746 | 17,091 | +1,345 | 0.03 | 0.03 | 0.00 | buy |
| E Fund Management Co., Ltd. | 5,073 | 6,203 | +1,130 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 12,113 | 12,778 | +665 | 0.05 | 0.04 | 0.00 | buy |
| Quarry LP | 2,300 | 2,000 | +300 | 0.03 | 0.02 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,465 | 1,576 | -889 | 0.05 | 0.03 | -0.02 | sell |
| Westover Capital Advisors, LLC | 6,224 | 4,900 | -1,324 | 0.05 | 0.05 | -0.01 | sell |
| Pier Capital, LLC | 103,463 | 102,128 | -1,335 | 0.64 | 0.62 | -0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 7,428 | 5,700 | -1,728 | 0.19 | 0.16 | -0.03 | sell |
| Brevan Howard Capital Management LP | 7,614 | 5,504 | -2,110 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 46,855 | 43,521 | -3,334 | 0.50 | 0.29 | -0.20 | sell |
| Affinity Asset Advisors, LLC | 435,000 | 425,000 | -10,000 | 2.62 | 2.41 | -0.21 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 137,389 | 119,664 | -17,725 | 0.27 | 0.30 | +0.02 | sell |
| Decheng Capital LLC | 69,767 | 49,767 | -20,000 | 0.73 | 0.45 | -0.28 | sell |
| Holocene Advisors, LP | 1,954,528 | 1,875,963 | -78,565 | 0.35 | 0.25 | -0.09 | sell |
| Siren, L.L.C. | 837,928 | 758,465 | -79,463 | 1.85 | 1.42 | -0.44 | sell |
| Candriam S.C.A. | 450,992 | 365,999 | -84,993 | 0.11 | 0.09 | -0.03 | sell |
| Kynam Capital Management, LP | 1,576,549 | 1,457,910 | -118,639 | 5.40 | 4.07 | -1.33 | sell |
| Altium Capital Management LLC | 684,000 | 432,000 | -252,000 | 9.01 | 5.69 | -3.32 | sell |
| Eversept Partners, LP | 2,050,157 | 1,600,015 | -450,142 | 6.21 | 6.01 | -0.20 | sell |
| Commodore Capital LP | 2,475,000 | 1,958,600 | -516,400 | 6.84 | 6.07 | -0.77 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,374,000 | 480,000 | -894,000 | 0.11 | 0.04 | -0.07 | sell |