| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 4,309,590 | 5,610,000 | +1,300,410 | 2.78 | 3.36 | +0.58 | buy |
| Vestal Point Capital, LP | 0 | 1,075,000 | +1,075,000 | 0.00 | 2.70 | +2.70 | buy |
| LORD, ABBETT & CO. LLC | 426,014 | 1,153,670 | +727,656 | 0.06 | 0.15 | +0.09 | buy |
| FEDERATED HERMES, INC. | 414,105 | 1,085,986 | +671,881 | 0.04 | 0.10 | +0.06 | buy |
| Integral Health Asset Management, LLC | 500,000 | 1,150,000 | +650,000 | 2.60 | 4.30 | +1.70 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 103,409 | 695,091 | +591,682 | 0.00 | 0.03 | +0.03 | buy |
| First Light Asset Management, LLC | 705,234 | 1,261,246 | +556,012 | 2.59 | 5.10 | +2.51 | buy |
| BlackRock, Inc. | 3,452,202 | 3,941,486 | +489,284 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,939,109 | 4,377,049 | +437,940 | 0.02 | 0.02 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 984,001 | 1,415,179 | +431,178 | 0.03 | 0.04 | +0.01 | buy |
| Logos Global Management LP | 500,000 | 875,000 | +375,000 | 2.48 | 4.33 | +1.85 | buy |
| VANGUARD GROUP INC | 2,580,177 | 2,949,564 | +369,387 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 447,098 | 813,861 | +366,763 | 0.01 | 0.02 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 1,096,851 | 1,437,339 | +340,488 | 1.70 | 2.11 | +0.42 | buy |
| SAMLYN CAPITAL, LLC | 1,359,227 | 1,662,220 | +302,993 | 0.97 | 1.12 | +0.15 | buy |
| Pictet Asset Management Holding SA | 571,998 | 841,313 | +269,315 | 0.03 | 0.04 | +0.01 | buy |
| FMR LLC | 2,785,284 | 3,053,126 | +267,842 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 257,788 | +257,788 | 0.00 | 1.55 | +1.55 | buy |
| MARSHALL WACE, LLP | 583,725 | 837,146 | +253,421 | 0.03 | 0.04 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 175,591 | 385,425 | +209,834 | 0.02 | 0.04 | +0.02 | buy |
| STATE STREET CORP | 1,823,807 | 2,026,352 | +202,545 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,000,893 | 1,202,466 | +201,573 | 0.37 | 0.34 | -0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 38,253 | 235,267 | +197,014 | 0.00 | 0.01 | +0.01 | buy |
| GW&K Investment Management, LLC | 0 | 186,605 | +186,605 | 0.00 | 0.07 | +0.07 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 178,283 | +178,283 | 0.00 | 0.18 | +0.18 | buy |
| Qube Research & Technologies Ltd | 13,376 | 170,486 | +157,110 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,004,665 | 1,153,325 | +148,660 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 47,683 | 189,088 | +141,405 | 0.11 | 0.34 | +0.23 | buy |
| JPMORGAN CHASE & CO | 80,795 | 221,485 | +140,690 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 326,494 | 464,807 | +138,313 | 2.28 | 3.52 | +1.24 | buy |
| Rock Springs Capital Management LP | 383,492 | 487,863 | +104,371 | 0.55 | 0.79 | +0.23 | buy |
| Avidity Partners Management LP | 0 | 100,000 | +100,000 | 0.00 | 0.42 | +0.42 | buy |
| NORTHERN TRUST CORP | 365,300 | 455,007 | +89,707 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 29,404 | 117,484 | +88,080 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 81,315 | 160,347 | +79,032 | 0.20 | 0.24 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 361,805 | 430,665 | +68,860 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 675,872 | 742,572 | +66,700 | 0.55 | 0.65 | +0.11 | buy |
| Cinctive Capital Management LP | 48,500 | 113,546 | +65,046 | 0.12 | 0.26 | +0.14 | buy |
| CITADEL ADVISORS LLC | 3,070 | 54,806 | +51,736 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 48,593 | +48,593 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 766,544 | 810,376 | +43,832 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 386,414 | 428,940 | +42,526 | 0.01 | 0.01 | +0.00 | buy |
| Cutter Capital Management, LP | 172,876 | 212,696 | +39,820 | 2.26 | 3.69 | +1.43 | buy |
| TD ASSET MANAGEMENT INC | 192,894 | 230,558 | +37,664 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 35,700 | +35,700 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 71,559 | 106,805 | +35,246 | 0.29 | 0.40 | +0.11 | buy |
| HighVista Strategies LLC | 22,010 | 52,197 | +30,187 | 0.34 | 0.82 | +0.49 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 30,880 | 59,004 | +28,124 | 0.02 | 0.03 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 12,003 | 39,576 | +27,573 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 45,968 | 73,160 | +27,192 | 0.34 | 0.42 | +0.08 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 101,861 | 128,380 | +26,519 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 24,722 | +24,722 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 24,374 | +24,374 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 171,573 | 194,027 | +22,454 | 0.03 | 0.02 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 62,197 | 83,077 | +20,880 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 35,869 | 54,599 | +18,730 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 61,574 | 80,106 | +18,532 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 69,700 | 85,400 | +15,700 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 23,164 | 38,550 | +15,386 | 0.03 | 0.04 | +0.01 | buy |
| UBS Group AG | 82,374 | 97,303 | +14,929 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 85,395 | 99,148 | +13,753 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,354 | 20,270 | +10,916 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 240 | 10,475 | +10,235 | 0.00 | 0.01 | +0.01 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 10,182 | +10,182 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 0 | 10,000 | +10,000 | 0.00 | 0.80 | +0.80 | buy |
| Rafferty Asset Management, LLC | 78,945 | 87,686 | +8,741 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 476,713 | 485,145 | +8,432 | 0.02 | 0.02 | -0.00 | buy |
| Legal & General Group Plc | 39,496 | 47,809 | +8,313 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 134,053 | 141,948 | +7,895 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,317 | 28,695 | +7,378 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 24,478 | 31,843 | +7,365 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 14,500 | 21,735 | +7,235 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 22,794 | 30,021 | +7,227 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,684 | 26,819 | +7,135 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 6,992 | +6,992 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 44,266 | 51,207 | +6,941 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,891 | 40,640 | +6,749 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 52,074 | 58,589 | +6,515 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,737 | 17,070 | +6,333 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 6,228 | +6,228 | 0.00 | 0.00 | +0.00 | buy |
| Moors & Cabot, Inc. | 0 | 5,200 | +5,200 | 0.00 | 0.01 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 17,101 | 22,290 | +5,189 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 5,011 | +5,011 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 10,604 | 15,487 | +4,883 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,113 | 28,822 | +4,709 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 22,778 | 26,803 | +4,025 | 0.01 | 0.01 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8,918 | 12,860 | +3,942 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,545 | 13,427 | +2,882 | 0.05 | 0.05 | +0.00 | buy |
| Arizona State Retirement System | 10,238 | 12,586 | +2,348 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 11,750 | 13,550 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 20,510 | 21,954 | +1,444 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 1,090 | 2,477 | +1,387 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 15,746 | 17,091 | +1,345 | 0.03 | 0.03 | +0.00 | buy |
| Corebridge Financial, Inc. | 20,837 | 22,047 | +1,210 | 0.00 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 5,073 | 6,203 | +1,130 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 6,682 | 7,736 | +1,054 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 39,550 | 40,350 | +800 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 794 | +794 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 12,113 | 12,778 | +665 | 0.04 | 0.04 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,000 | 4,639 | +639 | 0.01 | 0.01 | +0.00 | buy |