| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,666,439 | 5,461,976 | +1,795,537 | 0.01 | 0.03 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 679,992 | 31,779 | +648,213 | 0.02 | 0.00 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,641,157 | 4,059,695 | +418,538 | 1.62 | 2.63 | +1.01 | buy |
| First Light Asset Management, LLC | 507,097 | 869,676 | +362,579 | 1.39 | 3.37 | +1.98 | buy |
| BRAIDWELL LP | 472,739 | 784,742 | +312,003 | 0.41 | 1.27 | +0.86 | buy |
| Rhenman & Partners Asset Management AB | 130,000 | 420,000 | +290,000 | 0.42 | 1.99 | +1.57 | buy |
| Eversept Partners, LP | 2,807,836 | 3,072,304 | +264,468 | 5.62 | 7.84 | +2.22 | buy |
| First Turn Management, LLC | 354,529 | 601,774 | +247,245 | 1.55 | 3.48 | +1.93 | buy |
| ARMISTICE CAPITAL, LLC | 536,000 | 653,796 | +117,796 | 0.23 | 0.39 | +0.16 | buy |
| TD ASSET MANAGEMENT INC | 210,474 | 325,564 | +115,090 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 1,700,000 | 1,800,000 | +100,000 | 3.60 | 4.62 | +1.02 | buy |
| Swedbank AB | 50,000 | 121,200 | +71,200 | 0.00 | 0.01 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 67,193 | 29,442 | +37,751 | 0.05 | 0.04 | 0.00 | sell |
| GW&K Investment Management, LLC | 77,065 | 113,753 | +36,688 | 0.02 | 0.05 | +0.03 | buy |
| Headlands Technologies LLC | 7,993 | 42,825 | +34,832 | 0.02 | 0.18 | +0.16 | buy |
| Candriam S.C.A. | 427,189 | 449,554 | +22,365 | 0.06 | 0.11 | +0.05 | buy |
| ALPS ADVISORS INC | 30,750 | 52,392 | +21,642 | 0.00 | 0.02 | 0.00 | buy |
| PROFUND ADVISORS LLC | 18,992 | 32,024 | +13,032 | 0.02 | 0.05 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 32,286 | 42,374 | +10,088 | 0.03 | 0.07 | +0.04 | buy |
| SECTORAL ASSET MANAGEMENT INC | 30,188 | 36,858 | +6,670 | 0.54 | 1.50 | +0.95 | buy |
| Parkman Healthcare Partners LLC | 96,737 | 100,564 | +3,827 | 0.31 | 0.48 | +0.18 | buy |
| Perigon Wealth Management, LLC | 12,898 | 14,396 | +1,498 | 0.01 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 5,052 | 5,342 | +290 | 0.04 | 0.07 | +0.03 | buy |
| Optimize Financial Inc | 17,544 | 17,800 | +256 | 0.27 | 0.45 | +0.19 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,373 | 1,256 | -117 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,187 | 10,417 | -770 | 0.03 | 0.04 | +0.01 | sell |
| Rafferty Asset Management, LLC | 87,497 | 85,836 | -1,661 | 0.01 | 0.02 | +0.01 | sell |
| J. Safra Sarasin Holding AG | 55,317 | 52,327 | -2,990 | 0.03 | 0.04 | +0.02 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 34,936 | 30,682 | -4,254 | 0.04 | 0.07 | +0.03 | sell |
| Jasper Ridge Partners, L.P. | 15,639 | 10,154 | -5,485 | 0.01 | 0.01 | +0.00 | sell |
| GC Wealth Management RIA, LLC | 38,885 | 23,985 | -14,900 | 0.04 | 0.04 | +0.01 | sell |
| Soviero Asset Management, LP | 100,000 | 85,000 | -15,000 | 1.80 | 2.25 | +0.45 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 46,551 | 30,071 | -16,480 | 0.11 | 0.12 | +0.01 | sell |
| Exome Asset Management LLC | 156,072 | 124,391 | -31,681 | 2.99 | 3.11 | +0.12 | sell |
| Cinctive Capital Management LP | 96,573 | 64,617 | -31,956 | 0.14 | 0.19 | +0.05 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 159,751 | 119,384 | -40,367 | 0.30 | 1.40 | +1.10 | sell |
| Rock Springs Capital Management LP | 617,396 | 568,579 | -48,817 | 1.05 | 1.48 | +0.43 | sell |
| Affinity Asset Advisors, LLC | 303,330 | 250,000 | -53,330 | 0.82 | 0.91 | +0.09 | sell |
| Vestal Point Capital, LP | 760,000 | 550,000 | -210,000 | 1.00 | 1.02 | +0.02 | sell |
| Avoro Capital Advisors LLC | 6,210,000 | 5,888,888 | -321,112 | 2.33 | 2.93 | +0.60 | sell |
| Tri Locum Partners LP | 1,190,207 | 805,689 | -384,518 | 7.95 | 5.30 | -2.65 | sell |
| PFM Health Sciences, LP | 513,685 | 107,690 | -405,995 | 1.15 | 0.54 | -0.60 | sell |
| Kynam Capital Management, LP | 4,027,800 | 3,433,051 | -594,749 | 8.71 | 11.32 | +2.60 | sell |