| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,525,000 | 28,165,000 | +8,640,000 | 0.81 | 0.63 | -0.18 | buy |
| Rangeley Capital, LLC | 45,000 | 59,000 | +14,000 | 0.06 | 0.05 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 69,178 | 72,487 | +3,309 | 0.01 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 2,515,000 | 2,482,543 | -32,457 | 0.17 | 0.11 | -0.06 | sell |
| Redmile Group, LLC | 2,648,659 | 2,597,759 | -50,900 | 0.23 | 0.15 | -0.08 | sell |
| PERCEPTIVE ADVISORS LLC | 20,859,303 | 18,490,636 | -2,368,667 | 0.53 | 0.24 | -0.29 | sell |