| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 32,543,142 | 33,094,330 | +551,188 | 0.04 | 0.02 | -0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 21,785,166 | 20,859,303 | -925,863 | 0.99 | 0.54 | -0.45 | sell |
| BVF INC/IL | 19,525,000 | 19,525,000 | 0 | 1.62 | 0.81 | -0.81 | hold |
| MAVERICK CAPITAL LTD | 18,970,913 | 18,970,913 | 0 | 0.50 | 0.29 | -0.22 | hold |
| Saturn V Capital Management LP | 7,735,386 | 10,949,084 | +3,213,698 | 3.51 | 2.58 | -0.93 | buy |
| M28 Capital Management LP | 9,248,250 | 9,248,250 | 0 | 16.60 | 22.35 | +5.74 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 5,809,256 | 9,071,995 | +3,262,739 | 0.22 | 0.20 | -0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 13,062,945 | 8,436,894 | -4,626,051 | 0.22 | 0.08 | -0.14 | sell |
| Soleus Capital Management, L.P. | 7,708,727 | 7,708,727 | 0 | 0.81 | 0.41 | -0.40 | hold |
| STATE STREET CORP | 5,637,593 | 6,935,648 | +1,298,055 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 3,546,947 | 4,281,790 | +734,843 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 4,000,000 | 4,000,000 | 0 | 0.29 | 0.14 | -0.15 | hold |
| ADAR1 Capital Management, LLC | 3,899,397 | 3,822,427 | -76,970 | 0.72 | 0.30 | -0.42 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,661,480 | 3,661,480 | 0 | 0.01 | 0.01 | -0.01 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 3,806,976 | 3,515,644 | -291,332 | 0.02 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,286,455 | 3,511,581 | +2,225,126 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,638,367 | 3,388,182 | +1,749,815 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 210,648 | 2,687,195 | +2,476,547 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 2,656,570 | 2,656,570 | 0 | 0.85 | 0.49 | -0.36 | hold |
| Redmile Group, LLC | 2,681,159 | 2,648,659 | -32,500 | 0.49 | 0.23 | -0.26 | sell |
| GOLDMAN SACHS GROUP INC | 2,173,747 | 2,611,445 | +437,698 | 0.00 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 2,900,000 | 2,515,000 | -385,000 | 0.60 | 0.30 | -0.29 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,056,472 | 2,468,927 | +412,455 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 2,140,130 | 2,276,349 | +136,219 | 0.30 | 0.20 | -0.10 | buy |
| Ensign Peak Advisors, Inc | 0 | 2,019,207 | +2,019,207 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,191,900 | 1,969,659 | -222,241 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 625,783 | 1,903,713 | +1,277,930 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 989,822 | 1,874,546 | +884,724 | 0.42 | 0.47 | +0.05 | buy |
| CITADEL ADVISORS LLC | 331,083 | 1,589,575 | +1,258,492 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 1,500,000 | 1,500,000 | 0 | 0.81 | 0.26 | -0.55 | hold |
| MARSHALL WACE, LLP | 0 | 1,226,165 | +1,226,165 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 985,216 | 1,218,214 | +232,998 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 977,595 | +977,595 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 380,604 | 962,386 | +581,782 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,026,620 | 846,265 | -180,355 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 204,591 | 819,968 | +615,377 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 774,635 | 774,635 | 0 | 0.05 | 0.02 | -0.03 | hold |
| JANE STREET GROUP, LLC | 513,863 | 773,352 | +259,489 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 1,050,923 | 614,690 | -436,233 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 585,385 | 585,385 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 392,416 | 460,125 | +67,709 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 428,847 | 428,847 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Invesco Ltd. | 293,580 | 380,412 | +86,832 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 339,580 | +339,580 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 376,612 | 327,464 | -49,148 | 0.08 | 0.03 | -0.05 | sell |
| Rafferty Asset Management, LLC | 284,564 | 306,290 | +21,726 | 0.00 | 0.00 | -0.00 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 221,928 | +221,928 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 161,000 | +161,000 | 0.00 | 0.51 | +0.51 | buy |
| XTX Topco Ltd | 147,634 | 145,334 | -2,300 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 141,939 | 141,270 | -669 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 87,030 | 140,061 | +53,031 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 102,591 | 133,506 | +30,915 | 0.01 | 0.01 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 131,178 | +131,178 | 0.00 | 0.05 | +0.05 | buy |
| Virtu Financial LLC | 202,310 | 130,576 | -71,734 | 0.02 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 295,120 | 126,742 | -168,378 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 49,251 | 125,751 | +76,500 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 121,600 | +121,600 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,920 | 118,012 | +92 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 114,668 | 117,537 | +2,869 | 0.08 | 0.04 | -0.03 | buy |
| CITIGROUP INC | 137,984 | 109,874 | -28,110 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 98,100 | 106,900 | +8,800 | 0.00 | 0.00 | -0.00 | buy |
| Miller Financial Services LLC | 51,000 | 105,000 | +54,000 | 0.15 | 0.15 | +0.00 | buy |
| Knott David M Jr | 100,000 | 100,000 | 0 | 0.11 | 0.08 | -0.04 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,200 | 99,200 | 0 | 0.01 | 0.00 | -0.00 | hold |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC | 96,507 | 96,507 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EMERALD ADVISERS, LLC | 89,938 | 89,938 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Diametric Capital, LP | 0 | 87,807 | +87,807 | 0.00 | 0.03 | +0.03 | buy |
| a16z Perennial Management, L.P. | 79,869 | 79,869 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Quadrature Capital Ltd | 91,241 | 78,433 | -12,808 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 0 | 75,838 | +75,838 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 45,157 | 69,178 | +24,021 | 0.01 | 0.01 | -0.00 | buy |
| Jefferies Financial Group Inc. | 87,685 | 65,520 | -22,165 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 0 | 60,400 | +60,400 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 68,843 | 55,990 | -12,853 | 0.08 | 0.03 | -0.05 | sell |
| Schonfeld Strategic Advisors LLC | 14,460 | 52,531 | +38,071 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.06 | +0.06 | buy |
| Point72 Asset Management, L.P. | 16,653,036 | 43,931 | -16,609,105 | 0.06 | 0.00 | -0.06 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 42,631 | +42,631 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 39,798 | 39,909 | +111 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 38,805 | 39,309 | +504 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 38,502 | +38,502 | 0.00 | 0.00 | +0.00 | buy |
| NINE MASTS CAPITAL Ltd | 0 | 34,698 | +34,698 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 32,163 | +32,163 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 32,050 | +32,050 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 28,800 | +28,800 | 0.00 | 0.00 | +0.00 | buy |
| Ciovacco Capital Management LLC | 0 | 27,932 | +27,932 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 17,616 | 27,184 | +9,568 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 16,797 | 26,044 | +9,247 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 25,786 | +25,786 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 25,976 | 25,703 | -273 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 0 | 24,874 | +24,874 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD FINANCIAL GROUP, LTD. LLC | 23,094 | 23,094 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,600 | 21,307 | +4,707 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 20,933 | 20,933 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 0 | 20,500 | +20,500 | 0.00 | 0.00 | +0.00 | buy |
| FORTRESS PRIVATE LEDGER, LLC | 25,000 | 20,000 | -5,000 | 0.02 | 0.01 | -0.01 | sell |
| AXQ CAPITAL, LP | 0 | 19,984 | +19,984 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 19,045 | +19,045 | 0.00 | 0.12 | +0.12 | buy |
| Chicago Partners Investment Group LLC | 0 | 19,015 | +19,015 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 17,648 | +17,648 | 0.00 | 0.05 | +0.05 | buy |