| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,525,000 | 28,165,000 | +8,640,000 | 0.81 | 0.63 | -0.18 | buy |
| MAVERICK CAPITAL LTD | 18,970,913 | 18,970,913 | 0 | 0.29 | 0.15 | -0.14 | hold |
| PERCEPTIVE ADVISORS LLC | 20,859,303 | 18,490,636 | -2,368,667 | 0.54 | 0.25 | -0.29 | sell |
| BlackRock, Inc. | 4,281,790 | 16,134,885 | +11,853,095 | 0.00 | 0.00 | +0.00 | buy |
| M28 Capital Management LP | 9,248,250 | 9,248,250 | 0 | 22.35 | 17.11 | -5.24 | hold |
| Saturn V Capital Management LP | 10,949,084 | 8,392,288 | -2,556,796 | 2.58 | 1.05 | -1.53 | sell |
| Soleus Capital Management, L.P. | 7,708,727 | 7,708,727 | 0 | 0.41 | 0.23 | -0.17 | hold |
| Point72 Asset Management, L.P. | 43,931 | 7,542,061 | +7,498,130 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 3,388,182 | 5,730,948 | +2,342,766 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,468,927 | 5,418,774 | +2,949,847 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 4,000,000 | 5,000,000 | +1,000,000 | 0.14 | 0.09 | -0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 8,436,894 | 4,806,543 | -3,630,351 | 0.08 | 0.02 | -0.06 | sell |
| ADAR1 Capital Management, LLC | 3,822,427 | 3,807,427 | -15,000 | 0.30 | 0.16 | -0.14 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,661,480 | 3,661,480 | 0 | 0.01 | 0.00 | -0.00 | hold |
| CITADEL ADVISORS LLC | 1,589,575 | 3,580,941 | +1,991,366 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 6,935,648 | 3,457,428 | -3,478,220 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 2,687,195 | 3,320,238 | +633,043 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 2,656,570 | 2,656,570 | 0 | 0.49 | 0.38 | -0.11 | hold |
| Redmile Group, LLC | 2,648,659 | 2,597,759 | -50,900 | 0.23 | 0.15 | -0.08 | sell |
| 683 Capital Management, LLC | 2,515,000 | 2,482,543 | -32,457 | 0.30 | 0.20 | -0.10 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,969,659 | 2,333,474 | +363,815 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 2,276,349 | 2,237,015 | -39,334 | 0.20 | 0.11 | -0.09 | sell |
| Ensign Peak Advisors, Inc | 2,019,207 | 1,721,276 | -297,931 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 460,125 | 1,610,353 | +1,150,228 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 1,500,000 | 1,500,000 | 0 | 0.26 | 0.10 | -0.16 | hold |
| MILLENNIUM MANAGEMENT LLC | 3,511,581 | 1,205,599 | -2,305,982 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 846,265 | 995,334 | +149,069 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,611,445 | 978,552 | -1,632,893 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 585,385 | 790,749 | +205,364 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 774,635 | 774,635 | 0 | 0.02 | 0.01 | -0.01 | hold |
| GSA CAPITAL PARTNERS LLP | 327,464 | 662,065 | +334,601 | 0.03 | 0.04 | +0.01 | buy |
| Bank of New York Mellon Corp | 27,184 | 517,920 | +490,736 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 469,717 | +469,717 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,012 | 469,717 | +351,705 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,903,713 | 455,539 | -1,448,174 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 380,412 | 454,530 | +74,118 | 0.00 | 0.00 | -0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 450,115 | +450,115 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 428,847 | 428,847 | 0 | 0.03 | 0.01 | -0.01 | hold |
| Virtus Investment Advisers, LLC | 117,537 | 424,933 | +307,396 | 0.04 | 0.09 | +0.04 | buy |
| Birchview Capital, LP | 0 | 342,275 | +342,275 | 0.00 | 0.14 | +0.14 | buy |
| Nuveen, LLC | 0 | 280,333 | +280,333 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 819,968 | 231,475 | -588,493 | 0.00 | 0.00 | -0.00 | sell |
| MML INVESTORS SERVICES, LLC | 221,928 | 204,436 | -17,492 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 0 | 176,526 | +176,526 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 172,695 | +172,695 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 141,270 | 165,609 | +24,339 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 121,600 | 161,989 | +40,389 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 157,594 | +157,594 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 125,751 | 155,251 | +29,500 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 0 | 133,800 | +133,800 | 0.00 | 0.00 | +0.00 | buy |
| Miller Financial Services LLC | 105,000 | 133,000 | +28,000 | 0.15 | 0.09 | -0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 115,400 | +115,400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 109,874 | 112,675 | +2,801 | 0.00 | 0.00 | -0.00 | buy |
| SIMON QUICK ADVISORS, LLC | 0 | 106,555 | +106,555 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 100,000 | 100,000 | 0 | 0.08 | 0.05 | -0.03 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,200 | 99,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Voleon Capital Management LP | 0 | 97,214 | +97,214 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,307 | 96,921 | +75,614 | 0.00 | 0.00 | +0.00 | buy |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC | 96,507 | 96,507 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EMERALD ADVISERS, LLC | 89,938 | 89,938 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 126,742 | 81,960 | -44,782 | 0.00 | 0.00 | -0.00 | sell |
| a16z Perennial Management, L.P. | 79,869 | 79,869 | 0 | 0.01 | 0.01 | -0.00 | hold |
| XTX Topco Ltd | 145,334 | 72,531 | -72,803 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 69,178 | 72,487 | +3,309 | 0.01 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 62,079 | +62,079 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 60,800 | +60,800 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 59,213 | +59,213 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 45,000 | 59,000 | +14,000 | 0.06 | 0.05 | -0.02 | buy |
| Scientech Research LLC | 0 | 52,893 | +52,893 | 0.00 | 0.04 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 26,044 | 42,078 | +16,034 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 40,606 | +40,606 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,396 | 37,220 | +24,824 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 32,850 | +32,850 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 30,772 | +30,772 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 28,765 | +28,765 | 0.00 | 0.00 | +0.00 | buy |
| Massar Capital Management, LP | 0 | 28,273 | +28,273 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 25,703 | 27,058 | +1,355 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 39,909 | 23,402 | -16,507 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD FINANCIAL GROUP, LTD. LLC | 23,094 | 23,094 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArchPoint Investors | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 13,000 | 23,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 39,309 | 21,662 | -17,647 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 20,500 | 20,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 0 | 20,435 | +20,435 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 20,034 | +20,034 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 19,102 | +19,102 | 0.00 | 0.00 | +0.00 | buy |
| Wealthspire Advisors, LLC | 17,595 | 17,595 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quantinno Capital Management LP | 0 | 16,904 | +16,904 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 16,300 | +16,300 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 15,180 | 15,180 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of Wyoming | 10,312 | 15,144 | +4,832 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 14,455 | 13,176 | -1,279 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 19,015 | 12,683 | -6,332 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,157 | 10,443 | +5,286 | 0.00 | 0.00 | +0.00 | buy |
| COURIER CAPITAL LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NAPLES GLOBAL ADVISORS, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 2,036 | 9,583 | +7,547 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 6,128 | 5,929 | -199 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 0 | 4,242 | +4,242 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |