| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 25,383,077 | 32,543,142 | +7,160,065 | 0.01 | 0.04 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 21,785,166 | +21,785,166 | 0.00 | 0.99 | +0.99 | buy |
| BVF INC/IL | 0 | 19,525,000 | +19,525,000 | 0.00 | 1.62 | +1.62 | buy |
| MAVERICK CAPITAL LTD | 18,970,913 | 18,970,913 | 0 | 0.28 | 0.50 | +0.22 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 17,119,096 | 17,119,096 | 0 | 0.23 | 0.43 | +0.20 | hold |
| Point72 Asset Management, L.P. | 20,302,100 | 16,653,036 | -3,649,064 | 0.05 | 0.06 | +0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 10,105,078 | 13,062,945 | +2,957,867 | 0.08 | 0.22 | +0.14 | buy |
| VANGUARD GROUP INC | 5,762,894 | 10,703,977 | +4,941,083 | 0.00 | 0.00 | +0.00 | buy |
| M28 Capital Management LP | 9,248,250 | 9,248,250 | 0 | 14.96 | 16.60 | +1.65 | hold |
| Saturn V Capital Management LP | 0 | 7,735,386 | +7,735,386 | 0.00 | 3.51 | +3.51 | buy |
| Soleus Capital Management, L.P. | 0 | 7,708,727 | +7,708,727 | 0.00 | 0.81 | +0.81 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 5,809,256 | +5,809,256 | 0.00 | 0.22 | +0.22 | buy |
| STATE STREET CORP | 324,607 | 5,637,593 | +5,312,986 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 4,000,000 | +4,000,000 | 0.00 | 0.29 | +0.29 | buy |
| ADAR1 Capital Management, LLC | 7,370,987 | 3,899,397 | -3,471,590 | 0.80 | 0.72 | -0.08 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,806,976 | +3,806,976 | 0.00 | 0.02 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 3,661,480 | +3,661,480 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 718,888 | 3,546,947 | +2,828,059 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 6,300,000 | 2,900,000 | -3,400,000 | 0.63 | 0.60 | -0.03 | sell |
| Redmile Group, LLC | 2,285,320 | 2,681,159 | +395,839 | 0.24 | 0.49 | +0.24 | buy |
| Ikarian Capital, LLC | 2,078,706 | 2,656,570 | +577,864 | 0.46 | 0.85 | +0.39 | buy |
| TWO SIGMA INVESTMENTS, LP | 335,000 | 2,191,900 | +1,856,900 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 2,173,747 | +2,173,747 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 2,047,265 | 2,140,130 | +92,865 | 0.17 | 0.30 | +0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 732,344 | 2,056,472 | +1,324,128 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 1,638,367 | +1,638,367 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.81 | +0.81 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,446,615 | 1,286,455 | -160,160 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 0 | 1,050,923 | +1,050,923 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 1,026,620 | +1,026,620 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 278,608 | 989,822 | +711,214 | 0.06 | 0.42 | +0.36 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 985,216 | +985,216 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 916,600 | +916,600 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 812,706 | 774,635 | -38,071 | 0.02 | 0.05 | +0.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 625,783 | +625,783 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 585,385 | 585,385 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 765,443 | 513,863 | -251,580 | 0.00 | 0.00 | +0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 428,847 | +428,847 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 110,901 | 392,416 | +281,515 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 380,604 | +380,604 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 805,221 | 376,612 | -428,609 | 0.07 | 0.08 | +0.01 | sell |
| CITADEL ADVISORS LLC | 0 | 331,083 | +331,083 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 433,510 | 295,120 | -138,390 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 175,169 | 293,580 | +118,411 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 284,564 | +284,564 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 210,648 | +210,648 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 14,046 | 209,331 | +195,285 | 0.01 | 0.33 | +0.32 | buy |
| Squarepoint Ops LLC | 107,831 | 204,591 | +96,760 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 202,310 | +202,310 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 238,509 | 147,634 | -90,875 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 142,974 | 141,939 | -1,035 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 46,272 | 137,984 | +91,712 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 117,920 | +117,920 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 114,668 | +114,668 | 0.00 | 0.08 | +0.08 | buy |
| PROFUND ADVISORS LLC | 0 | 102,591 | +102,591 | 0.00 | 0.01 | +0.01 | buy |
| Knott David M Jr | 100,000 | 100,000 | 0 | 0.05 | 0.11 | +0.07 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,200 | 99,200 | 0 | 0.00 | 0.01 | +0.00 | hold |
| OMERS ADMINISTRATION Corp | 0 | 98,100 | +98,100 | 0.00 | 0.00 | +0.00 | buy |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC | 96,507 | 96,507 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quadrature Capital Ltd | 46,012 | 91,241 | +45,229 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 0 | 89,938 | +89,938 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 92,300 | 87,685 | -4,615 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 87,030 | +87,030 | 0.00 | 0.00 | +0.00 | buy |
| a16z Perennial Management, L.P. | 79,869 | 79,869 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Persistent Asset Partners Ltd | 0 | 68,843 | +68,843 | 0.00 | 0.08 | +0.08 | buy |
| Lighthouse Investment Partners, LLC | 0 | 63,000 | +63,000 | 0.00 | 0.01 | +0.01 | buy |
| Miller Financial Services LLC | 37,000 | 51,000 | +14,000 | 0.05 | 0.15 | +0.10 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 49,906 | +49,906 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 49,251 | +49,251 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 45,157 | +45,157 | 0.00 | 0.01 | +0.01 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 42,127 | +42,127 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 39,930 | +39,930 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,609 | 39,798 | +29,189 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 39,616 | 38,805 | -811 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 19,077 | 25,976 | +6,899 | 0.00 | 0.00 | +0.00 | buy |
| FORTRESS PRIVATE LEDGER, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 0 | 24,146 | +24,146 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD FINANCIAL GROUP, LTD. LLC | 23,094 | 23,094 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 20,933 | 20,933 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 0 | 17,616 | +17,616 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,025 | 16,797 | +15,772 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 16,600 | +16,600 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 0 | 15,180 | +15,180 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 14,460 | +14,460 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 13,466 | +13,466 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 0 | 13,139 | +13,139 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 12,322 | +12,322 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,240 | +12,240 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 11,716 | 11,686 | -30 | 0.00 | 0.00 | +0.00 | sell |
| DRW Securities, LLC | 0 | 11,124 | +11,124 | 0.00 | 0.00 | +0.00 | buy |
| Bronte Capital Management Pty Ltd. | 0 | 11,012 | +11,012 | 0.00 | 0.00 | +0.00 | buy |
| COURIER CAPITAL LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| NAPLES GLOBAL ADVISORS, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sunbelt Securities, Inc. | 7,500 | 7,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 0 | 5,446 | +5,446 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 4,000 | 2,000 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 1,123 | 1,070 | -53 | 0.00 | 0.00 | +0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 0 | 950 | +950 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 923 | +923 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 889 | 889 | 0 | 0.00 | 0.00 | +0.00 | hold |