| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,270,697 | 10,901,485 | +2,630,788 | 0.71 | 1.42 | +0.70 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,596,922 | 3,104,681 | +1,507,759 | 0.02 | 0.06 | +0.04 | buy |
| Hood River Capital Management LLC | 2,920,836 | 3,106,690 | +185,854 | 0.32 | 0.50 | +0.18 | buy |
| PDT Partners, LLC | 21,488 | 109,806 | +88,318 | 0.01 | 0.08 | +0.07 | buy |
| ALGERT GLOBAL LLC | 60,718 | 55,853 | +4,865 | 0.01 | 0.02 | 0.00 | sell |
| Cresset Asset Management, LLC | 295,768 | 295,819 | +51 | 0.01 | 0.01 | 0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 82,091 | 66,881 | -15,210 | 0.01 | 0.02 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 340,000 | 140,000 | -200,000 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 8,304,142 | 8,033,241 | -270,901 | 0.03 | 0.04 | +0.01 | sell |
| Rhenman & Partners Asset Management AB | 2,022,736 | 1,641,448 | -381,288 | 0.95 | 1.23 | +0.28 | sell |