| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 1,028,549 | 2,415,841 | +1,387,292 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 187,052 | +187,052 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 825,576 | 987,090 | +161,514 | 1.41 | 0.81 | -0.60 | buy |
| ROYCE & ASSOCIATES LP | 0 | 155,050 | +155,050 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,257,000 | 1,410,815 | +153,815 | 0.16 | 0.11 | -0.05 | buy |
| AdvisorShares Investments LLC | 98,058 | 195,604 | +97,546 | 0.13 | 0.17 | +0.04 | buy |
| CITADEL ADVISORS LLC | 805,377 | 877,347 | +71,970 | 0.00 | 0.00 | -0.00 | buy |
| Knott David M Jr | 285,182 | 350,000 | +64,818 | 1.08 | 1.00 | -0.08 | buy |
| DAFNA Capital Management LLC | 455,018 | 498,361 | +43,343 | 0.86 | 0.54 | -0.32 | buy |
| AXQ CAPITAL, LP | 0 | 29,114 | +29,114 | 0.00 | 0.02 | +0.02 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 22,277 | +22,277 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 0 | 18,000 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management (UK) Ltd. | 0 | 15,000 | +15,000 | 0.00 | 0.04 | +0.04 | buy |
| VR Adviser, LLC | 3,840,250 | 3,851,654 | +11,404 | 1.55 | 0.69 | -0.86 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 10,900 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| Formidable Asset Management, LLC | 0 | 10,649 | +10,649 | 0.00 | 0.01 | +0.01 | buy |
| Mayflower Financial Advisors, LLC | 0 | 10,290 | +10,290 | 0.00 | 0.01 | +0.01 | buy |
| Centiva Capital, LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Millington Financial Advisors, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 2,556 | 11,873 | +9,317 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 99,034 | 106,349 | +7,315 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 6,400 | +6,400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 5,952 | +5,952 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 233,714 | 238,302 | +4,588 | 0.00 | 0.00 | -0.00 | buy |
| Quent Capital, LLC | 0 | 4,453 | +4,453 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 25,403 | 29,126 | +3,723 | 0.00 | 0.00 | -0.00 | buy |
| Advisory Services Network, LLC | 0 | 2,060 | +2,060 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 2,500 | 3,380 | +880 | 0.00 | 0.00 | -0.00 | buy |
| Ancora Advisors LLC | 0 | 653 | +653 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 7 | 7 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 700,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Westside Investment Management, Inc. | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 29,404 | 29,404 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 95 | 95 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NVWM, LLC | 59 | 59 | 0 | 0.00 | 0.00 | -0.00 | hold |
| McIlrath & Eck, LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CNB Bank | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FNY Investment Advisers, LLC | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ikarian Capital, LLC | 132,153 | 132,153 | 0 | 0.14 | 0.09 | -0.05 | hold |
| Nan Fung Group Holdings Ltd | 460,000 | 460,000 | 0 | 3.37 | 1.82 | -1.55 | hold |
| Avalon Trust Co | 197 | 197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TSFG, LLC | 2 | 2 | 0 | 0.00 | 0.00 | 0.00 | hold |
| IAG Wealth Partners, LLC | 2,750 | 2,750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CoreCap Advisors, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| City State Bank | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pale Fire Capital SE | 153,505 | 153,505 | 0 | 0.16 | 0.06 | -0.10 | hold |
| Tidemark, LLC | 131 | 131 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atlantic Edge Private Wealth Management, LLC | 137 | 137 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 3,121 | 3,121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIFLEX GROUP, INC. | 131 | 131 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 862 | 862 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CENTRAL TRUST Co | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDS Planning, Inc | 30,344 | 30,344 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Arax Advisory Partners | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Larson Financial Group LLC | 21 | 0 | -21 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 247 | 221 | -26 | 0.00 | 0.00 | -0.00 | sell |
| Root Financial Partners, LLC | 65 | 0 | -65 | 0.00 | 0.00 | -0.00 | sell |
| FLAGSHIP HARBOR ADVISORS, LLC | 105 | 0 | -105 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 5,408 | 5,132 | -276 | 0.00 | 0.00 | -0.00 | sell |
| Global Wealth Strategies & Associates | 526 | 0 | -526 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 925 | 0 | -925 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 2,033 | 117 | -1,916 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 10,725 | 3,462 | -7,263 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 3,840,500 | 3,832,843 | -7,657 | 0.64 | 0.40 | -0.24 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 11,010 | 0 | -11,010 | 0.00 | 0.00 | -0.00 | sell |
| PEAK6 LLC | 78,608 | 62,597 | -16,011 | 0.02 | 0.01 | -0.01 | sell |
| Graham Capital Management, L.P. | 35,509 | 18,263 | -17,246 | 0.01 | 0.00 | -0.01 | sell |
| Diametric Capital, LP | 17,758 | 0 | -17,758 | 0.04 | 0.00 | -0.04 | sell |
| ROYAL BANK OF CANADA | 51,082 | 31,592 | -19,490 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 22,443 | 0 | -22,443 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 30,000 | 0 | -30,000 | 0.07 | 0.00 | -0.07 | sell |
| Fore Capital, LLC | 66,421 | 36,421 | -30,000 | 0.72 | 0.41 | -0.31 | sell |
| ACORN CAPITAL ADVISORS, LLC | 1,573,023 | 1,540,266 | -32,757 | 4.36 | 2.10 | -2.26 | sell |
| GOLDMAN SACHS GROUP INC | 47,931 | 0 | -47,931 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 715,000 | 640,000 | -75,000 | 1.28 | 0.40 | -0.88 | sell |
| Quadrature Capital Ltd | 79,697 | 0 | -79,697 | 0.01 | 0.00 | -0.01 | sell |
| DCF Advisers, LLC | 775,588 | 691,988 | -83,600 | 2.10 | 1.25 | -0.84 | sell |
| Rosalind Advisors, Inc. | 1,657,540 | 1,531,814 | -125,726 | 4.94 | 3.01 | -1.93 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 300,230 | 147,925 | -152,305 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 339,902 | 134,060 | -205,842 | 2.20 | 0.57 | -1.63 | sell |
| ADAR1 Capital Management, LLC | 238,390 | 31,278 | -207,112 | 0.15 | 0.01 | -0.14 | sell |
| MORGAN STANLEY | 1,299,756 | 1,025,318 | -274,438 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 1,854,255 | 1,313,137 | -541,118 | 0.35 | 0.13 | -0.22 | sell |
| ArrowMark Colorado Holdings LLC | 598,419 | 0 | -598,419 | 0.11 | 0.00 | -0.11 | sell |
| Point72 Asset Management, L.P. | 4,432,559 | 19,684 | -4,412,875 | 0.06 | 0.00 | -0.06 | sell |