| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 987,090 | 1,620,753 | +633,663 | 0.75 | 1.40 | +0.65 | buy |
| Rosalind Advisors, Inc. | 1,531,814 | 1,956,814 | +425,000 | 2.95 | 4.80 | +1.85 | buy |
| Stonepine Capital Management, LLC | 134,060 | 330,530 | +196,470 | 0.26 | 0.45 | +0.19 | buy |
| AdvisorShares Investments LLC | 195,604 | 292,711 | +97,107 | 0.17 | 0.23 | +0.06 | buy |
| Mitsubishi UFJ Asset Management (UK) Ltd. | 15,000 | 31,000 | +16,000 | 0.00 | 0.10 | +0.10 | buy |
| DAFNA Capital Management LLC | 498,361 | 514,061 | +15,700 | 0.54 | 0.65 | +0.10 | buy |
| China Universal Asset Management Co., Ltd. | 6,400 | 6,000 | -400 | 0.00 | 0.00 | +0.00 | sell |
| Formidable Asset Management, LLC | 10,649 | 10,217 | -432 | 0.01 | 0.01 | -0.01 | sell |