| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 3,840,500 | +3,840,500 | 0.00 | 0.64 | +0.64 | buy |
| VR Adviser, LLC | 0 | 3,840,250 | +3,840,250 | 0.00 | 1.55 | +1.55 | buy |
| Point72 Asset Management, L.P. | 1,239,629 | 4,432,559 | +3,192,930 | 0.02 | 0.06 | +0.04 | buy |
| MORGAN STANLEY | 0 | 1,299,756 | +1,299,756 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,257,000 | +1,257,000 | 0.00 | 0.16 | +0.16 | buy |
| MILLENNIUM MANAGEMENT LLC | 69,101 | 1,028,549 | +959,448 | 0.00 | 0.01 | +0.01 | buy |
| Deep Track Capital, LP | 1,000,000 | 1,854,255 | +854,255 | 0.16 | 0.35 | +0.18 | buy |
| ACORN CAPITAL ADVISORS, LLC | 734,394 | 1,573,023 | +838,629 | 2.19 | 4.36 | +2.17 | buy |
| DCF Advisers, LLC | 0 | 775,588 | +775,588 | 0.00 | 2.10 | +2.10 | buy |
| Boxer Capital Management, LLC | 0 | 715,000 | +715,000 | 0.00 | 1.28 | +1.28 | buy |
| CITADEL ADVISORS LLC | 97,094 | 805,377 | +708,283 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 700,000 | +700,000 | 0.00 | 0.01 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 598,419 | +598,419 | 0.00 | 0.11 | +0.11 | buy |
| Nan Fung Group Holdings Ltd | 0 | 460,000 | +460,000 | 0.00 | 3.37 | +3.37 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 370,376 | 825,576 | +455,200 | 0.52 | 1.41 | +0.89 | buy |
| DAFNA Capital Management LLC | 0 | 455,018 | +455,018 | 0.00 | 0.86 | +0.86 | buy |
| Stonepine Capital Management, LLC | 0 | 339,902 | +339,902 | 0.00 | 2.20 | +2.20 | buy |
| ADAR1 Capital Management, LLC | 33,278 | 238,390 | +205,112 | 0.02 | 0.15 | +0.13 | buy |
| Rosalind Advisors, Inc. | 1,500,000 | 1,657,540 | +157,540 | 3.12 | 4.94 | +1.82 | buy |
| Knott David M Jr | 140,242 | 285,182 | +144,940 | 0.35 | 1.08 | +0.73 | buy |
| PEAK6 LLC | 82,708 | 204,899 | +122,191 | 0.01 | 0.06 | +0.05 | buy |
| JANE STREET GROUP, LLC | 0 | 99,034 | +99,034 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 79,697 | +79,697 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 47,931 | +47,931 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 35,509 | +35,509 | 0.00 | 0.01 | +0.01 | buy |
| MYDA Advisors LLC | 0 | 30,000 | +30,000 | 0.00 | 0.07 | +0.07 | buy |
| ROYAL BANK OF CANADA | 23,895 | 51,082 | +27,187 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 273,795 | 300,230 | +26,435 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 22,443 | +22,443 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 11,010 | +11,010 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 10,725 | +10,725 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 16,126 | 17,758 | +1,632 | 0.04 | 0.04 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 925 | +925 | 0.00 | 0.00 | +0.00 | buy |
| AMERIFLEX GROUP, INC. | 0 | 131 | +131 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,442 | 2,556 | +114 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 0 | 105 | +105 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 147 | 247 | +100 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1 | 7 | +6 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 2,500 | 2,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Westside Investment Management, Inc. | 26 | 26 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 95 | 95 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NVWM, LLC | 59 | 59 | 0 | 0.00 | 0.00 | +0.00 | hold |
| McIlrath & Eck, LLC | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Larson Financial Group LLC | 21 | 21 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CNB Bank | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avalon Trust Co | 197 | 197 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IAG Wealth Partners, LLC | 2,750 | 2,750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CoreCap Advisors, LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| City State Bank | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Wealth Strategies & Associates | 526 | 526 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pale Fire Capital SE | 153,505 | 153,505 | 0 | 0.10 | 0.16 | +0.06 | hold |
| Root Financial Partners, LLC | 65 | 65 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tidemark, LLC | 131 | 131 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atlantic Edge Private Wealth Management, LLC | 137 | 137 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 3,121 | 3,121 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 862 | 862 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CENTRAL TRUST Co | 26 | 26 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PDS Planning, Inc | 30,344 | 30,344 | 0 | 0.01 | 0.02 | +0.00 | hold |
| TSFG, LLC | 15 | 2 | -13 | 0.00 | 0.00 | 0.00 | sell |
| Allworth Financial LP | 46 | 20 | -26 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 5,477 | 5,408 | -69 | 0.00 | 0.00 | +0.00 | sell |
| Atlantic Union Bankshares Corp | 250 | 0 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Wealthspire Advisors, LLC | 253 | 0 | -253 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 3,705 | 3,100 | -605 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 2,753 | 2,033 | -720 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| PEAK6 LLC | 82,708 | 78,608 | -4,100 | 0.01 | 0.02 | +0.01 | sell |
| Fore Capital, LLC | 71,421 | 66,421 | -5,000 | 0.53 | 0.72 | +0.19 | sell |
| Advisory Services Network, LLC | 5,060 | 0 | -5,060 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 8,236 | 0 | -8,236 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 37,726 | 29,404 | -8,322 | 0.01 | 0.01 | +0.00 | sell |
| Ikarian Capital, LLC | 140,475 | 132,153 | -8,322 | 0.17 | 0.14 | -0.03 | sell |
| Mayflower Financial Advisors, LLC | 10,290 | 0 | -10,290 | 0.01 | 0.00 | -0.01 | sell |
| COWA, LLC | 13,200 | 0 | -13,200 | 0.03 | 0.00 | -0.03 | sell |
| Lewis Asset Management, LLC | 13,946 | 0 | -13,946 | 0.03 | 0.00 | -0.03 | sell |
| AdvisorShares Investments LLC | 116,102 | 98,058 | -18,044 | 0.11 | 0.13 | +0.02 | sell |
| OXFORD ASSET MANAGEMENT LLP | 50,805 | 0 | -50,805 | 0.10 | 0.00 | -0.10 | sell |
| FNY Investment Advisers, LLC | 50,944 | 100 | -50,844 | 0.10 | 0.00 | -0.10 | sell |
| Walleye Capital LLC | 53,250 | 0 | -53,250 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 55,761 | 0 | -55,761 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 303,740 | 233,714 | -70,026 | 0.00 | 0.00 | +0.00 | sell |
| DLD Asset Management, LP | 80,000 | 0 | -80,000 | 0.06 | 0.00 | -0.06 | sell |
| MARSHALL WACE, LLP | 86,911 | 0 | -86,911 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 141,320 | 25,403 | -115,917 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,830,097 | 0 | -1,830,097 | 0.41 | 0.00 | -0.41 | sell |