| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 0 | 7,967,207 | +7,967,207 | 0.00 | 2.16 | +2.16 | buy |
| PERCEPTIVE ADVISORS LLC | 803,210 | 6,431,743 | +5,628,533 | 0.06 | 0.49 | +0.43 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 3,405,553 | +3,405,553 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 475,439 | 3,760,439 | +3,285,000 | 0.00 | 0.03 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 324,090 | 3,032,697 | +2,708,607 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 1,481,660 | +1,481,660 | 0.00 | 0.13 | +0.13 | buy |
| Ensign Peak Advisors, Inc | 0 | 1,375,610 | +1,375,610 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 283,645 | 1,476,106 | +1,192,461 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 1,050,000 | +1,050,000 | 0.00 | 0.16 | +0.16 | buy |
| ExodusPoint Capital Management, LP | 86,113 | 768,627 | +682,514 | 0.00 | 0.03 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 0 | 575,000 | +575,000 | 0.00 | 0.13 | +0.13 | buy |
| LMR Partners LLP | 0 | 539,588 | +539,588 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 500,000 | +500,000 | 0.00 | 1.04 | +1.04 | buy |
| Propel Bio Management, LLC | 652,881 | 1,012,790 | +359,909 | 2.08 | 2.45 | +0.36 | buy |
| Jefferies Financial Group Inc. | 580,328 | 903,094 | +322,766 | 0.02 | 0.04 | +0.02 | buy |
| BlackRock, Inc. | 17,239 | 301,326 | +284,087 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 275,000 | +275,000 | 0.00 | 0.07 | +0.07 | buy |
| STEMPOINT CAPITAL LP | 146,558 | 375,000 | +228,442 | 0.09 | 0.28 | +0.18 | buy |
| MARSHALL WACE, LLP | 236,460 | 463,925 | +227,465 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 200,000 | 400,000 | +200,000 | 0.07 | 0.17 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 119,517 | 302,036 | +182,519 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 181,185 | +181,185 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 51,348 | 113,940 | +62,592 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 13,122 | 74,231 | +61,109 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 59,161 | +59,161 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 11,550 | 61,741 | +50,191 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.17 | +0.17 | buy |
| Persistent Asset Partners Ltd | 19,790 | 69,732 | +49,942 | 0.04 | 0.10 | +0.07 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 46,455 | +46,455 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 16,412 | 57,426 | +41,014 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 37,943 | +37,943 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 37,455 | +37,455 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 35,264 | +35,264 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 34,124 | +34,124 | 0.00 | 0.01 | +0.01 | buy |
| FIFTH LANE CAPITAL, LP | 15,000 | 46,500 | +31,500 | 0.07 | 0.22 | +0.15 | buy |
| Diametric Capital, LP | 0 | 16,292 | +16,292 | 0.00 | 0.02 | +0.02 | buy |
| Hudson Bay Capital Management LP | 0 | 16,100 | +16,100 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 15,100 | +15,100 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 0 | 10,816 | +10,816 | 0.00 | 0.03 | +0.03 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 7,700 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 29,974 | 36,805 | +6,831 | 0.00 | 0.00 | +0.00 | buy |
| Plante Moran Financial Advisors, LLC | 0 | 5,925 | +5,925 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 4,713 | +4,713 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,269 | +3,269 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,850,881 | 2,851,791 | +910 | 0.04 | 0.04 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 889 | +889 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 496 | +496 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 161 | +161 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 217 | 217 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 1,811 | 1,811 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,401,500 | 4,401,500 | 0 | 0.17 | 0.18 | +0.01 | hold |
| Sessa Capital IM, L.P. | 2,198,457 | 2,198,457 | 0 | 0.16 | 0.16 | -0.00 | hold |
| First PREMIER Bank | 18,986 | 18,986 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Vivo Capital, LLC | 11,420,000 | 11,420,000 | 0 | 2.76 | 3.64 | +0.88 | hold |
| GS Investments, Inc. | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Commodore Capital LP | 4,401,500 | 4,401,500 | 0 | 1.10 | 0.98 | -0.12 | hold |
| HB Wealth Management, LLC | 307,500 | 307,500 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Pathstone Holdings, LLC | 50,650 | 50,650 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| GTS SECURITIES LLC | 41,101 | 41,001 | -100 | 0.00 | 0.00 | +0.00 | sell |
| NewEdge Advisors, LLC | 1,072 | 0 | -1,072 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 8,971 | 7,899 | -1,072 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 19,201 | 14,036 | -5,165 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 31,147 | 24,098 | -7,049 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON CORP | 10,527 | 0 | -10,527 | 0.92 | 0.00 | -0.92 | sell |
| OMERS ADMINISTRATION Corp | 42,000 | 29,700 | -12,300 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 208,227 | 187,230 | -20,997 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 26,344 | 0 | -26,344 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 26,867 | 0 | -26,867 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 2,143,585 | 860,170 | -1,283,415 | 0.03 | 0.01 | -0.02 | sell |