| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,405,553 | 6,405,553 | +3,000,000 | 0.02 | 0.04 | +0.01 | buy |
| BlackRock, Inc. | 301,326 | 3,066,016 | +2,764,690 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 302,036 | 1,277,185 | +975,149 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 575,000 | 1,525,000 | +950,000 | 0.13 | 0.29 | +0.16 | buy |
| STATE STREET CORP | 74,231 | 530,831 | +456,600 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 438,515 | +438,515 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 365,878 | +365,878 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 306,581 | +306,581 | 0.00 | 0.12 | +0.12 | buy |
| NORTHERN TRUST CORP | 57,426 | 362,489 | +305,063 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 6,431,743 | 6,627,501 | +195,758 | 0.49 | 0.40 | -0.09 | buy |
| Bank of New York Mellon Corp | 0 | 107,847 | +107,847 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 105,682 | +105,682 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 105,682 | +105,682 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 77,600 | +77,600 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 113,940 | 191,305 | +77,365 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 1,012,790 | 1,076,578 | +63,788 | 2.45 | 2.20 | -0.25 | buy |
| Nuveen, LLC | 0 | 58,398 | +58,398 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 37,455 | 84,685 | +47,230 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 45,164 | +45,164 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 44,083 | +44,083 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 42,371 | +42,371 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 38,699 | +38,699 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 35,620 | +35,620 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 496 | 35,902 | +35,406 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 181,185 | 214,632 | +33,447 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 28,015 | +28,015 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 26,970 | +26,970 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 50,000 | 73,271 | +23,271 | 0.17 | 0.22 | +0.05 | buy |
| Invesco Ltd. | 0 | 22,593 | +22,593 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 21,223 | +21,223 | 0.00 | 0.00 | 0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 19,996 | +19,996 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 12,947 | +12,947 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 12,900 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 12,807 | +12,807 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 8,500 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 889 | 8,633 | +7,744 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 10,816 | 17,446 | +6,630 | 0.03 | 0.06 | +0.02 | buy |
| Legal & General Group Plc | 0 | 4,223 | +4,223 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,941 | +3,941 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 7,700 | 10,270 | +2,570 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,852 | +1,852 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 1,811 | 3,289 | +1,478 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 875 | +875 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 598 | +598 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 161 | 742 | +581 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 41,001 | 41,301 | +300 | 0.00 | 0.00 | -0.00 | buy |
| TORONTO DOMINION BANK | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,760,439 | 3,760,439 | 0 | 0.03 | 0.03 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,401,500 | 4,401,500 | 0 | 0.18 | 0.15 | -0.03 | hold |
| Plante Moran Financial Advisors, LLC | 5,925 | 5,925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,481,660 | 1,481,660 | 0 | 0.13 | 0.11 | -0.02 | hold |
| LMR Partners LLP | 539,588 | 539,588 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sessa Capital IM, L.P. | 2,198,457 | 2,198,457 | 0 | 0.16 | 0.15 | -0.01 | hold |
| First PREMIER Bank | 18,986 | 18,986 | 0 | 0.02 | 0.01 | -0.00 | hold |
| GS Investments, Inc. | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caligan Partners LP | 7,967,207 | 7,967,207 | 0 | 2.16 | 1.50 | -0.66 | hold |
| HB Wealth Management, LLC | 307,500 | 307,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Pathstone Holdings, LLC | 50,650 | 50,650 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MAI Capital Management | 217 | 0 | -217 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,269 | 2,520 | -749 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 4,713 | 0 | -4,713 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 7,899 | 0 | -7,899 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 36,805 | 26,584 | -10,221 | 0.00 | 0.00 | -0.00 | sell |
| Kestra Advisory Services, LLC | 61,741 | 49,811 | -11,930 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 14,036 | 0 | -14,036 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 15,100 | 0 | -15,100 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 16,100 | 0 | -16,100 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 16,292 | 0 | -16,292 | 0.02 | 0.00 | -0.02 | sell |
| Quadrature Capital Ltd | 35,264 | 15,195 | -20,069 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 24,098 | 0 | -24,098 | 0.00 | 0.00 | -0.00 | sell |
| AWM Investment Company, Inc. | 400,000 | 375,000 | -25,000 | 0.17 | 0.13 | -0.04 | sell |
| OMERS ADMINISTRATION Corp | 29,700 | 0 | -29,700 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 375,000 | 342,631 | -32,369 | 0.28 | 0.23 | -0.04 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 34,124 | 0 | -34,124 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 37,943 | 0 | -37,943 | 0.01 | 0.00 | -0.01 | sell |
| Persistent Asset Partners Ltd | 69,732 | 25,400 | -44,332 | 0.10 | 0.03 | -0.07 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 46,455 | 0 | -46,455 | 0.00 | 0.00 | -0.00 | sell |
| FIFTH LANE CAPITAL, LP | 46,500 | 0 | -46,500 | 0.22 | 0.00 | -0.22 | sell |
| Brevan Howard Capital Management LP | 59,161 | 0 | -59,161 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 187,230 | 104,849 | -82,381 | 0.01 | 0.01 | -0.01 | sell |
| Soleus Capital Management, L.P. | 1,050,000 | 900,000 | -150,000 | 0.16 | 0.12 | -0.04 | sell |
| Ensign Peak Advisors, Inc | 1,375,610 | 1,172,641 | -202,969 | 0.01 | 0.01 | -0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 275,000 | 0 | -275,000 | 0.07 | 0.00 | -0.07 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,032,697 | 2,749,087 | -283,610 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 463,925 | 0 | -463,925 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 500,000 | 0 | -500,000 | 1.04 | 0.00 | -1.04 | sell |
| ExodusPoint Capital Management, LP | 768,627 | 0 | -768,627 | 0.03 | 0.00 | -0.03 | sell |
| Blackstone Inc. | 860,170 | 0 | -860,170 | 0.01 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 1,476,106 | 611,019 | -865,087 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 903,094 | 0 | -903,094 | 0.04 | 0.00 | -0.04 | sell |
| Commodore Capital LP | 4,401,500 | 2,870,000 | -1,531,500 | 0.98 | 0.67 | -0.31 | sell |
| Woodline Partners LP | 2,851,791 | 1,180,355 | -1,671,436 | 0.04 | 0.01 | -0.03 | sell |
| Vivo Capital, LLC | 11,420,000 | 7,299,909 | -4,120,091 | 3.64 | 2.60 | -1.04 | sell |