| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 11,420,000 | +11,420,000 | 0.00 | 1.85 | +1.85 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,401,500 | +4,401,500 | 0.00 | 0.11 | +0.11 | buy |
| Commodore Capital LP | 0 | 4,401,500 | +4,401,500 | 0.00 | 0.43 | +0.43 | buy |
| Woodline Partners LP | 0 | 2,850,881 | +2,850,881 | 0.00 | 0.03 | +0.03 | buy |
| Sessa Capital IM, L.P. | 458,457 | 2,198,457 | +1,740,000 | 0.02 | 0.11 | +0.09 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 566,395 | +566,395 | 0.00 | 0.27 | +0.27 | buy |
| HB Wealth Management, LLC | 0 | 307,500 | +307,500 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 282,371 | 365,753 | +83,382 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 11,030 | 80,840 | +69,810 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 19,982 | +19,982 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 15,781 | +15,781 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 917,826 | 932,697 | +14,871 | 0.06 | 0.08 | +0.02 | buy |
| CAXTON CORP | 0 | 10,935 | +10,935 | 0.00 | 0.10 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 84,772 | 85,718 | +946 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 726 | 1,560 | +834 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 832 | +832 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 50 | 52 | +2 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 217 | 217 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LMR Partners LLP | 539,588 | 539,588 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 1,072 | 1,072 | 0 | 0.00 | 0.00 | -0.00 | hold |
| First PREMIER Bank | 18,986 | 18,986 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Kovitz Investment Group Partners, LLC | 19,201 | 19,201 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GS Investments, Inc. | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kestra Advisory Services, LLC | 11,930 | 11,930 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pathstone Holdings, LLC | 50,650 | 50,650 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 11,387 | 11,387 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 4,620 | 1,811 | -2,809 | 0.00 | 0.00 | -0.00 | sell |
| Sachetta, LLC | 4,100 | 0 | -4,100 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 11,852 | 0 | -11,852 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 31,863 | 11,436 | -20,427 | 0.00 | 0.00 | -0.00 | sell |