| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| 683 Capital Management, LLC | 0 | 900,000 | +900,000 | 0.00 | 0.22 | +0.22 | buy |
| ADAR1 Capital Management, LLC | 0 | 742,400 | +742,400 | 0.00 | 0.12 | +0.12 | buy |
| Ikarian Capital, LLC | 4,788,486 | 5,388,486 | +600,000 | 1.75 | 1.88 | +0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 47,050 | 474,601 | +427,551 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 310,000 | +310,000 | 0.00 | 0.71 | +0.71 | buy |
| Richmond Brothers, Inc. | 173,485 | 476,584 | +303,099 | 0.31 | 0.83 | +0.52 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 278,808 | +278,808 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 209,493 | +209,493 | 0.00 | 0.35 | +0.35 | buy |
| DIADEMA PARTNERS LP | 0 | 200,690 | +200,690 | 0.00 | 0.22 | +0.22 | buy |
| Knott David M Jr | 200,000 | 387,835 | +187,835 | 0.26 | 0.60 | +0.34 | buy |
| Burkehill Global Management, LP | 0 | 150,000 | +150,000 | 0.00 | 0.02 | +0.02 | buy |
| Simplify Asset Management Inc. | 0 | 51,475 | +51,475 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 47,465 | +47,465 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH LANE CAPITAL, LP | 0 | 45,000 | +45,000 | 0.00 | 0.14 | +0.14 | buy |
| XTX Topco Ltd | 0 | 41,128 | +41,128 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 26,774 | 50,747 | +23,973 | 0.04 | 0.05 | +0.02 | buy |
| Virtu Financial LLC | 0 | 16,914 | +16,914 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 23,320 | 32,129 | +8,809 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 16,503 | 19,766 | +3,263 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 40,400 | 40,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 780 | 780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 792,696 | 792,696 | 0 | 0.04 | 0.04 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,234,582 | 1,234,582 | 0 | 0.09 | 0.07 | -0.01 | hold |
| BML Capital Management, LLC | 408,887 | 408,887 | 0 | 1.02 | 0.69 | -0.33 | hold |
| MONOGRAPH WEALTH ADVISORS, LLC | 11,130 | 11,130 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Koa Wealth Management, LLC | 49,600 | 49,600 | 0 | 0.10 | 0.09 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 98 | 0 | -98 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 16,785 | 15,299 | -1,486 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 10,449 | 0 | -10,449 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 143,100 | 120,700 | -22,400 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 128,368 | 66,013 | -62,355 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 80,808 | 0 | -80,808 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 99,493 | 0 | -99,493 | 0.00 | 0.00 | -0.00 | sell |