| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 5,388,486 | 4,538,534 | -849,952 | 1.88 | 1.77 | -0.11 | sell |
| 683 Capital Management, LLC | 900,000 | 1,285,000 | +385,000 | 0.22 | 0.28 | +0.06 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,234,582 | 973,732 | -260,850 | 0.07 | 0.04 | -0.03 | sell |
| BlackRock, Inc. | 0 | 871,653 | +871,653 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 792,696 | 792,696 | 0 | 0.04 | 0.03 | -0.01 | hold |
| ADAR1 Capital Management, LLC | 742,400 | 700,000 | -42,400 | 0.12 | 0.08 | -0.04 | sell |
| BML Capital Management, LLC | 408,887 | 573,287 | +164,400 | 0.69 | 0.78 | +0.09 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 545,000 | +545,000 | 0.00 | 0.14 | +0.14 | buy |
| Richmond Brothers, Inc. | 476,584 | 535,612 | +59,028 | 0.83 | 0.66 | -0.17 | buy |
| Knott David M Jr | 387,835 | 444,862 | +57,027 | 0.60 | 0.56 | -0.05 | buy |
| Stonepine Capital Management, LLC | 310,000 | 364,254 | +54,254 | 0.71 | 0.66 | -0.05 | buy |
| MARSHALL WACE, LLP | 66,013 | 335,642 | +269,629 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 32,129 | 257,454 | +225,325 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 47,465 | 199,381 | +151,916 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 200,690 | 196,985 | -3,705 | 0.22 | 0.17 | -0.05 | sell |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 120,700 | 87,300 | -33,400 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 0 | 82,862 | +82,862 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 81,948 | +81,948 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 0 | 66,700 | +66,700 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 50,747 | 49,873 | -874 | 0.05 | 0.04 | -0.01 | sell |
| Koa Wealth Management, LLC | 49,600 | 49,600 | 0 | 0.09 | 0.08 | -0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 48,400 | +48,400 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 474,601 | 43,708 | -430,893 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 40,400 | 40,940 | +540 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 36,760 | +36,760 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 36,760 | +36,760 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 41,128 | 28,659 | -12,469 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 0 | 23,953 | +23,953 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 19,773 | +19,773 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 15,069 | +15,069 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 12,469 | +12,469 | 0.00 | 0.00 | +0.00 | buy |
| MONOGRAPH WEALTH ADVISORS, LLC | 11,130 | 11,130 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 780 | 10,979 | +10,199 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 6,986 | +6,986 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 6,904 | +6,904 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 5,000 | 5,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 0 | 2,879 | +2,879 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,415 | +2,415 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,290 | +2,290 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 996 | +996 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 882 | +882 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 150 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 278,808 | 0 | -278,808 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 15,299 | 0 | -15,299 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 16,914 | 0 | -16,914 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 19,766 | 0 | -19,766 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 51,475 | 0 | -51,475 | 0.00 | 0.00 | -0.00 | sell |
| FIFTH LANE CAPITAL, LP | 45,000 | 0 | -45,000 | 0.14 | 0.00 | -0.14 | sell |
| Propel Bio Management, LLC | 209,493 | 0 | -209,493 | 0.35 | 0.00 | -0.35 | sell |