| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 378,556 | 909,269 | +530,713 | 0.04 | 0.10 | +0.06 | buy |
| Monashee Investment Management LLC | 0 | 192,344 | +192,344 | 0.00 | 1.90 | +1.90 | buy |
| Cable Car Capital, LP | 754,749 | 781,599 | +26,850 | 1.30 | 0.10 | -1.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 19,900 | +19,900 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 11,271 | +11,271 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 129,214 | 135,090 | +5,876 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 81,696 | 86,930 | +5,234 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 2 | 464 | +462 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 1,110,002 | 1,110,002 | 0 | 0.18 | 0.17 | -0.01 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 66,666 | 66,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 24 | 24 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 334,445 | 334,445 | 0 | 0.02 | 0.02 | +0.00 | hold |
| NEA Management Company, LLC | 50,005 | 50,005 | 0 | 0.01 | 0.02 | +0.00 | hold |
| BML Capital Management, LLC | 200,730 | 200,730 | 0 | 0.65 | 0.68 | +0.03 | hold |
| Sofinnova Investments, Inc. | 31,884 | 31,884 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NewEdge Advisors, LLC | 160 | 160 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 455,361 | 455,361 | 0 | 1.40 | 1.45 | +0.05 | hold |
| BARCLAYS PLC | 10,959 | 10,797 | -162 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 224 | 0 | -224 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,011 | 675 | -336 | 0.00 | 0.00 | -0.00 | sell |
| Aldebaran Capital, LLC | 18,566 | 18,124 | -442 | 0.07 | 0.08 | +0.01 | sell |
| HSBC HOLDINGS PLC | 34,884 | 34,228 | -656 | 0.00 | 0.00 | +0.00 | sell |
| Shay Capital LLC | 19,130 | 18,080 | -1,050 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 59,929 | 53,512 | -6,417 | 0.00 | 0.00 | -0.00 | sell |
| Rangeley Capital, LLC | 32,590 | 20,090 | -12,500 | 0.18 | 0.11 | -0.07 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,990 | 0 | -12,990 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 13,909 | 0 | -13,909 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,112 | 0 | -15,112 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 26,663 | 0 | -26,663 | 0.00 | 0.00 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 959,337 | 917,692 | -41,645 | 1.29 | 0.82 | -0.47 | sell |
| CITADEL ADVISORS LLC | 124,345 | 0 | -124,345 | 0.00 | 0.00 | -0.00 | sell |