| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 8,131,952 | 10,689,545 | +2,557,593 | 0.86 | 2.00 | +1.14 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,502,788 | +1,502,788 | 0.00 | 0.93 | +0.93 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,410,438 | +1,410,438 | 0.00 | 0.37 | +0.37 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 486,611 | 1,520,932 | +1,034,321 | 0.15 | 0.94 | +0.79 | buy |
| Sofinnova Investments, Inc. | 23,038 | 503,624 | +480,586 | 0.01 | 0.44 | +0.43 | buy |
| Octagon Capital Advisors LP | 0 | 376,117 | +376,117 | 0.00 | 0.67 | +0.67 | buy |
| VANGUARD GROUP INC | 506,179 | 850,445 | +344,266 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,100,000 | 1,333,611 | +233,611 | 0.02 | 0.04 | +0.02 | buy |
| Artal Group S.A. | 0 | 200,000 | +200,000 | 0.00 | 0.08 | +0.08 | buy |
| Point72 Asset Management, L.P. | 0 | 192,178 | +192,178 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 988,204 | 1,166,642 | +178,438 | 0.00 | 0.01 | +0.01 | buy |
| Laurion Capital Management LP | 664,516 | 841,431 | +176,915 | 0.16 | 0.34 | +0.18 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 114,385 | +114,385 | 0.00 | 1.11 | +1.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 210,053 | 299,487 | +89,434 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 85,886 | +85,886 | 0.00 | 0.15 | +0.15 | buy |
| Walleye Capital LLC | 0 | 64,614 | +64,614 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 1,370 | 40,610 | +39,240 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 35,000 | +35,000 | 0.00 | 0.05 | +0.05 | buy |
| Qube Research & Technologies Ltd | 123 | 24,786 | +24,663 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 216,914 | 240,982 | +24,068 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 19,057 | +19,057 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 74,825 | 92,195 | +17,370 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 16,702 | +16,702 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 15,482 | +15,482 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 10,057 | +10,057 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 5,794 | +5,794 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 4,229 | +4,229 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,790 | 31,290 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 3,476 | +3,476 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 2,052 | +2,052 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,900 | 3,600 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 596 | +596 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,841 | 13,851 | +10 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,175 | 1,175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 1,482,434 | 0 | 0.04 | 0.08 | +0.04 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,200 | 99,200 | 0 | 0.01 | 0.03 | +0.02 | hold |
| ALLIANCEBERNSTEIN L.P. | 12,060 | 12,060 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 853 | 853 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,483 | 6,480 | -3 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 4,996 | 4,953 | -43 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,654 | 1,010 | -644 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 31,418 | 30,760 | -658 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 1,213 | 337 | -876 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 14,156 | 13,213 | -943 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,760 | 269 | -1,491 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 13,724 | 7,003 | -6,721 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 19,807 | 0 | -19,807 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 62,003 | 32,003 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 738,022 | 458,640 | -279,382 | 0.00 | 0.00 | +0.00 | sell |
| Samsara BioCapital, LLC | 436,813 | 0 | -436,813 | 0.46 | 0.00 | -0.46 | sell |