| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 2,675,937 | +2,675,937 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 156,636 | 1,033,018 | +876,382 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 780,897 | +780,897 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,000 | 1,350,000 | +550,000 | 0.01 | 0.00 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,174,321 | 1,660,932 | +486,611 | 0.16 | 0.09 | -0.07 | buy |
| Opaleye Management Inc. | 110,000 | 420,000 | +310,000 | 0.07 | 0.13 | +0.06 | buy |
| Ikarian Capital, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.07 | +0.07 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 87,003 | +87,003 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 70,144 | +70,144 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 46,194 | +46,194 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 45,570 | +45,570 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 45,300 | +45,300 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 26,559 | +26,559 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 20,352 | +20,352 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 582 | 19,989 | +19,407 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,139 | +18,139 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 17,626 | +17,626 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 372,855 | 383,893 | +11,038 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 10,600 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 9,900 | +9,900 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,286,126 | 1,294,253 | +8,127 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 27 | 6,040 | +6,013 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 44,735 | 48,518 | +3,783 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 2,740 | +2,740 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,899 | 9,289 | +390 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 295 | +295 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 313 | 546 | +233 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 145 | +145 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 684 | 808 | +124 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 18,954 | 19,071 | +117 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,050 | 6,159 | +109 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 12,385 | 12,402 | +17 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,175 | 1,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,126 | 1,126 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ZACKS INVESTMENT MANAGEMENT | 38,047 | 38,047 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 1,482,434 | 0 | 0.02 | 0.01 | -0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 17,650 | 17,650 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,689,545 | 10,689,545 | 0 | 0.54 | 0.25 | -0.29 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 810,761 | 810,761 | 0 | 0.19 | 0.09 | -0.10 | hold |
| Police & Firemen's Retirement System of New Jersey | 3,123 | 3,123 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,678 | 1,678 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,485 | 6,485 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 10,200 | 10,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 337 | 337 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 33,487 | 33,467 | -20 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,086 | 1,021 | -65 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 7,723 | 7,610 | -113 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 195 | 0 | -195 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,911 | 6,558 | -353 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,384 | 1,907 | -477 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 57,102 | 54,629 | -2,473 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 322,893 | 320,103 | -2,790 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 26,413 | 22,043 | -4,370 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 48,351 | 40,070 | -8,281 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 912,670 | 899,734 | -12,936 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 14,080 | 0 | -14,080 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 14,418 | 0 | -14,418 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 157,038 | 141,039 | -15,999 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 17,833 | 0 | -17,833 | 0.04 | 0.00 | -0.04 | sell |
| AMERICAN CENTURY COMPANIES INC | 22,605 | 0 | -22,605 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 31,287 | 0 | -31,287 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 98,900 | 56,923 | -41,977 | 0.01 | 0.00 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 47,506 | 0 | -47,506 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 98,344 | 40,240 | -58,104 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 136,262 | 0 | -136,262 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 522,256 | 0 | -522,256 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 553,478 | 0 | -553,478 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 653,016 | 0 | -653,016 | 0.05 | 0.00 | -0.05 | sell |
| PERCEPTIVE ADVISORS LLC | 829,536 | 0 | -829,536 | 0.09 | 0.00 | -0.09 | sell |
| RTW INVESTMENTS, LP | 3,193,097 | 0 | -3,193,097 | 0.18 | 0.00 | -0.18 | sell |