| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 197,943 | 2,079,143 | +1,881,200 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 36,842 | 1,607,638 | +1,570,796 | 0.02 | 0.17 | +0.15 | buy |
| Commodore Capital LP | 3,400,000 | 4,475,000 | +1,075,000 | 1.47 | 0.46 | -1.02 | buy |
| Laurion Capital Management LP | 2,052,133 | 2,750,855 | +698,722 | 0.91 | 0.46 | -0.45 | buy |
| Qube Research & Technologies Ltd | 31,234 | 706,472 | +675,238 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 1,300,000 | 1,830,925 | +530,925 | 0.82 | 0.36 | -0.46 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 138,398 | 598,663 | +460,265 | 0.59 | 0.29 | -0.30 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,498 | 442,168 | +316,670 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 0 | 158,826 | +158,826 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 150,925 | +150,925 | 0.00 | 0.11 | +0.11 | buy |
| LUMINUS MANAGEMENT LLC | 0 | 150,000 | +150,000 | 0.00 | 0.16 | +0.16 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 121,974 | +121,974 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 31,213 | 146,596 | +115,383 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 135,216 | 216,824 | +81,608 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 66,402 | +66,402 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 20,838 | 64,607 | +43,769 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 43,537 | +43,537 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,234,414 | 1,277,784 | +43,370 | 0.00 | 0.00 | -0.00 | buy |
| Scientech Research LLC | 0 | 42,073 | +42,073 | 0.00 | 0.06 | +0.06 | buy |
| Persistent Asset Partners Ltd | 0 | 38,152 | +38,152 | 0.00 | 0.03 | +0.03 | buy |
| XTX Topco Ltd | 98,036 | 131,151 | +33,115 | 0.02 | 0.00 | -0.01 | buy |
| Rangeley Capital, LLC | 36,200 | 68,096 | +31,896 | 0.20 | 0.13 | -0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 27,012 | +27,012 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 15,750 | 42,601 | +26,851 | 0.00 | 0.00 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 36,125 | 61,073 | +24,948 | 0.02 | 0.01 | -0.01 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 19,774 | +19,774 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 18,974 | +18,974 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 17,400 | +17,400 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 15,300 | +15,300 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 15,221 | +15,221 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 217,490 | 229,390 | +11,900 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,153 | +10,153 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 290,589 | 298,568 | +7,979 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 192,733 | 197,391 | +4,658 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 2,006 | +2,006 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 113,502 | 115,116 | +1,614 | 0.03 | 0.01 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 11,202 | 12,200 | +998 | 0.01 | 0.00 | -0.00 | buy |
| Accent Capital Management, LLC | 0 | 718 | +718 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 326 | +326 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,341 | 3,586 | +245 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 69,391 | 69,593 | +202 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,350 | 1,533 | +183 | 0.00 | 0.00 | -0.00 | buy |
| Fortitude Family Office, LLC | 0 | 112 | +112 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 28 | 68 | +40 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 3,482,434 | 3,482,434 | 0 | 0.06 | 0.02 | -0.04 | hold |
| RBF Capital, LLC | 95,042 | 95,042 | 0 | 0.03 | 0.01 | -0.02 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 20,064,545 | 20,064,545 | 0 | 1.34 | 0.38 | -0.96 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 2,325,000 | 2,325,000 | 0 | 0.98 | 0.34 | -0.64 | hold |
| Parallel Advisors, LLC | 135 | 135 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 447,165 | 447,165 | 0 | 0.38 | 0.11 | -0.26 | hold |
| Woodline Partners LP | 1,311,021 | 1,311,021 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Artia Global Partners LP | 205,324 | 205,324 | 0 | 0.21 | 0.08 | -0.13 | hold |
| FMR LLC | 1,664 | 1,664 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 195 | 195 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Larson Financial Group LLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| OPTIMA CAPITAL LLC | 108 | 0 | -108 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 27,600 | 24,900 | -2,700 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 13,729 | 10,289 | -3,440 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,489 | 5,540 | -3,949 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 73,306 | 69,123 | -4,183 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 43,440 | 38,286 | -5,154 | 0.02 | 0.00 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 542,109 | 535,999 | -6,110 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 10,001 | 0 | -10,001 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 55,717 | 45,130 | -10,587 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 118,257 | 104,899 | -13,358 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 14,580 | 0 | -14,580 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 63,000 | 43,700 | -19,300 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 20,806 | 0 | -20,806 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 24,306 | 0 | -24,306 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 89,575 | 63,732 | -25,843 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 31,337 | 2,506 | -28,831 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 315,000 | 279,909 | -35,091 | 0.01 | 0.00 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 120,728 | 79,581 | -41,147 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 43,194 | 0 | -43,194 | 0.01 | 0.00 | -0.01 | sell |
| Pictet Asset Management Holding SA | 1,352,424 | 1,306,783 | -45,641 | 0.01 | 0.00 | -0.01 | sell |
| Resolute Capital Asset Partners LLC | 50,000 | 0 | -50,000 | 0.16 | 0.00 | -0.16 | sell |
| Jump Financial, LLC | 55,438 | 0 | -55,438 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 267,789 | 207,922 | -59,867 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 417,996 | 351,374 | -66,622 | 0.07 | 0.01 | -0.06 | sell |
| MORGAN STANLEY | 1,084,400 | 998,987 | -85,413 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 267,425 | 181,705 | -85,720 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 147,900 | 56,800 | -91,100 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | 0 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 373,892 | 272,892 | -101,000 | 0.53 | 0.06 | -0.47 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 121,467 | 0 | -121,467 | 0.17 | 0.00 | -0.17 | sell |
| Polymer Capital Management (HK) LTD | 160,000 | 0 | -160,000 | 0.16 | 0.00 | -0.16 | sell |
| 683 Capital Management, LLC | 186,916 | 0 | -186,916 | 0.10 | 0.00 | -0.10 | sell |
| GOLDMAN SACHS GROUP INC | 241,618 | 0 | -241,618 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 255,974 | 0 | -255,974 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 351,141 | 0 | -351,141 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 700,000 | 0 | -700,000 | 0.57 | 0.00 | -0.57 | sell |
| Siren, L.L.C. | 700,000 | 0 | -700,000 | 0.14 | 0.00 | -0.14 | sell |
| PERCEPTIVE ADVISORS LLC | 829,870 | 0 | -829,870 | 0.10 | 0.00 | -0.10 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 866,269 | 14,293 | -851,976 | 0.01 | 0.00 | -0.01 | sell |
| Nantahala Capital Management, LLC | 1,547,229 | 681,158 | -866,071 | 0.60 | 0.08 | -0.53 | sell |
| JANUS HENDERSON GROUP PLC | 1,500,000 | 0 | -1,500,000 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 1,915,000 | 0 | -1,915,000 | 0.42 | 0.00 | -0.42 | sell |