| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 0 | 531,097 | +531,097 | 0.00 | 0.05 | +0.05 | buy |
| Invesco Ltd. | 0 | 231,064 | +231,064 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 174,036 | +174,036 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 299,487 | 379,097 | +79,610 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 240,982 | 317,393 | +76,411 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 503,624 | 561,128 | +57,504 | 0.44 | 0.56 | +0.13 | buy |
| VANGUARD GROUP INC | 850,445 | 903,393 | +52,948 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 39,898 | +39,898 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 22,899 | +22,899 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 21,494 | +21,494 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 19,057 | 36,086 | +17,029 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 31,290 | 46,763 | +15,473 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 30,760 | 44,157 | +13,397 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 12,251 | +12,251 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 269 | 7,024 | +6,755 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 3,600 | 10,200 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 92,195 | 97,483 | +5,288 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,851 | 18,853 | +5,002 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 12,060 | 16,040 | +3,980 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 5,794 | 9,420 | +3,626 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 16,702 | 20,028 | +3,326 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 2,621 | +2,621 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,229 | 6,725 | +2,496 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,476 | 5,184 | +1,708 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 853 | 1,678 | +825 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 353 | +353 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,010 | 1,126 | +116 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 9 | 32 | +23 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,480 | 6,485 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1 | 2 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,175 | 1,175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 1,482,434 | 0 | 0.08 | 0.09 | +0.01 | hold |
| PERCEPTIVE ADVISORS LLC | 1,410,438 | 1,410,438 | 0 | 0.37 | 0.54 | +0.18 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,689,545 | 10,689,545 | 0 | 2.00 | 2.26 | +0.26 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Laurion Capital Management LP | 841,431 | 841,431 | 0 | 0.34 | 0.44 | +0.09 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,520,932 | 1,520,932 | 0 | 0.94 | 0.99 | +0.05 | hold |
| Octagon Capital Advisors LP | 376,117 | 376,117 | 0 | 0.67 | 0.99 | +0.32 | hold |
| Frazier Life Sciences Management, L.P. | 1,502,788 | 1,502,788 | 0 | 0.93 | 1.12 | +0.19 | hold |
| AMALGAMATED BANK | 337 | 337 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 596 | 0 | -596 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 2,052 | 706 | -1,346 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 7,003 | 5,248 | -1,755 | 0.00 | 0.00 | -0.00 | sell |
| Crestline Management, LP | 35,000 | 31,230 | -3,770 | 0.05 | 0.04 | -0.01 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 4,953 | 0 | -4,953 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,333,611 | 1,327,536 | -6,075 | 0.04 | 0.04 | +0.00 | sell |
| UBS Group AG | 10,057 | 0 | -10,057 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 13,213 | 0 | -13,213 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 15,482 | 0 | -15,482 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 24,786 | 0 | -24,786 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 40,610 | 3,399 | -37,211 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 192,178 | 145,174 | -47,004 | 0.01 | 0.01 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 99,200 | 48,700 | -50,500 | 0.03 | 0.02 | -0.01 | sell |
| Walleye Capital LLC | 64,614 | 0 | -64,614 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 458,640 | 388,767 | -69,873 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 114,385 | 29,249 | -85,136 | 1.11 | 0.59 | -0.52 | sell |
| Monashee Investment Management LLC | 85,886 | 0 | -85,886 | 0.15 | 0.00 | -0.15 | sell |
| Artal Group S.A. | 200,000 | 113,317 | -86,683 | 0.08 | 0.05 | -0.03 | sell |
| JANUS HENDERSON GROUP PLC | 1,166,642 | 541,875 | -624,767 | 0.01 | 0.00 | -0.00 | sell |