| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 1,033,018 | 1,509,198 | +476,180 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 243,980 | +243,980 | 0.00 | 0.07 | +0.07 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 156,467 | +156,467 | 0.00 | 0.05 | +0.05 | buy |
| RBF Capital, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 2,675,937 | 2,759,171 | +83,234 | 0.01 | 0.01 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 73,004 | +73,004 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 39,209 | +39,209 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 899,734 | 937,023 | +37,289 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56,923 | 91,923 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 40,240 | 70,603 | +30,363 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 15,000 | 35,000 | +20,000 | 0.02 | 0.05 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 46,194 | 63,740 | +17,546 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,907 | 8,523 | +6,616 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 45,300 | 51,300 | +6,000 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 10,600 | 15,939 | +5,339 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,159 | 9,570 | +3,411 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,021 | 1,264 | +243 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 295 | 505 | +210 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,558 | 6,572 | +14 | 0.00 | 0.00 | -0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 38,047 | 38,047 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 1,482,434 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,350,000 | 1,350,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,689,545 | 10,689,545 | 0 | 0.25 | 0.20 | -0.05 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 810,761 | 810,761 | 0 | 0.09 | 0.10 | +0.02 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 45,570 | 45,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 150,000 | 150,000 | 0 | 0.07 | 0.06 | -0.01 | hold |
| ADAR1 Capital Management, LLC | 20,352 | 20,352 | 0 | 0.01 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 808 | 808 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 67 | 0 | -67 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 145 | 0 | -145 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 337 | 0 | -337 | 0.00 | 0.00 | 0.00 | sell |
| CoreCap Advisors, LLC | 546 | 0 | -546 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,126 | 0 | -1,126 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,175 | 0 | -1,175 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,678 | 0 | -1,678 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 6,040 | 3,576 | -2,464 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 2,740 | 137 | -2,603 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 3,123 | 0 | -3,123 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 12,402 | 6,602 | -5,800 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 9,900 | 4,039 | -5,861 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,485 | 0 | -6,485 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 7,610 | 0 | -7,610 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,289 | 0 | -9,289 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 10,200 | 0 | -10,200 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 19,989 | 5,603 | -14,386 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 54,629 | 39,699 | -14,930 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 17,626 | 0 | -17,626 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 17,650 | 0 | -17,650 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 18,139 | 0 | -18,139 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 22,043 | 3,704 | -18,339 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 19,071 | 0 | -19,071 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 26,559 | 0 | -26,559 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 33,467 | 0 | -33,467 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,070 | 0 | -40,070 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 48,518 | 0 | -48,518 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 87,003 | 32,705 | -54,298 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 70,144 | 0 | -70,144 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 780,897 | 691,530 | -89,367 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 141,039 | 47,986 | -93,053 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 98,701 | 0 | -98,701 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 420,000 | 240,000 | -180,000 | 0.13 | 0.05 | -0.08 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 383,893 | 201,096 | -182,797 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 320,103 | 69,140 | -250,963 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 1,294,253 | 648,021 | -646,232 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,660,932 | 300,000 | -1,360,932 | 0.09 | 0.01 | -0.08 | sell |