| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 541,875 | 2,336,516 | +1,794,641 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 797,358 | +797,358 | 0.00 | 0.12 | +0.12 | buy |
| Opaleye Management Inc. | 0 | 179,200 | +179,200 | 0.00 | 0.26 | +0.26 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,520,932 | 1,660,932 | +140,000 | 0.99 | 0.51 | -0.48 | buy |
| Walleye Capital LLC | 0 | 60,654 | +60,654 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 58,802 | +58,802 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 97,483 | 149,054 | +51,571 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 45,232 | +45,232 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 26,611 | +26,611 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 22,738 | +22,738 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 22,899 | 40,517 | +17,618 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 5,248 | 21,971 | +16,723 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 903,393 | 919,415 | +16,022 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 15,241 | +15,241 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 14,800 | +14,800 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 13,822 | +13,822 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 11,103 | +11,103 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,399 | 11,462 | +8,063 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 706 | 8,455 | +7,749 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,881 | 8,519 | +3,638 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 20,028 | 22,780 | +2,752 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 2,100 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 16,040 | 17,650 | +1,610 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 46,763 | 48,351 | +1,588 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 6,725 | 8,246 | +1,521 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 2 | 16 | +14 | 0.00 | 0.00 | 0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,175 | 1,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,126 | 1,126 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 1,482,434 | 0 | 0.09 | 0.05 | -0.04 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,700 | 48,700 | 0 | 0.02 | 0.01 | -0.01 | hold |
| PERCEPTIVE ADVISORS LLC | 1,410,438 | 1,410,438 | 0 | 0.54 | 0.26 | -0.28 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,689,545 | 10,689,545 | 0 | 2.26 | 1.05 | -1.20 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 9,420 | 9,420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 76 | 76 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Octagon Capital Advisors LP | 376,117 | 376,117 | 0 | 0.99 | 0.51 | -0.48 | hold |
| Legal & General Group Plc | 1,678 | 1,678 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,485 | 6,485 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 10,200 | 10,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 337 | 337 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 8,357 | 8,306 | -51 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 5,184 | 5,052 | -132 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 353 | 0 | -353 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 18,853 | 18,380 | -473 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 12,000 | 11,300 | -700 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 36,086 | 34,812 | -1,274 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 317,393 | 315,574 | -1,819 | 0.00 | 0.00 | -0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 39,898 | 38,047 | -1,851 | 0.01 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 2,621 | 0 | -2,621 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,024 | 3,327 | -3,697 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 379,097 | 375,325 | -3,772 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 44,157 | 33,487 | -10,670 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 12,251 | 0 | -12,251 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 21,494 | 0 | -21,494 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 29,249 | 0 | -29,249 | 0.59 | 0.00 | -0.59 | sell |
| Laurion Capital Management LP | 841,431 | 810,761 | -30,670 | 0.44 | 0.44 | +0.01 | sell |
| Crestline Management, LP | 31,230 | 0 | -31,230 | 0.04 | 0.00 | -0.04 | sell |
| Artal Group S.A. | 113,317 | 0 | -113,317 | 0.05 | 0.00 | -0.05 | sell |
| Point72 Asset Management, L.P. | 145,174 | 0 | -145,174 | 0.01 | 0.00 | -0.01 | sell |
| Woodline Partners LP | 174,036 | 0 | -174,036 | 0.03 | 0.00 | -0.03 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,327,536 | 1,127,536 | -200,000 | 0.04 | 0.02 | -0.02 | sell |
| Invesco Ltd. | 231,064 | 0 | -231,064 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 388,767 | 61,607 | -327,160 | 0.00 | 0.00 | -0.00 | sell |
| Polar Capital Holdings Plc | 531,097 | 0 | -531,097 | 0.05 | 0.00 | -0.05 | sell |
| Sofinnova Investments, Inc. | 561,128 | 0 | -561,128 | 0.56 | 0.00 | -0.56 | sell |
| Frazier Life Sciences Management, L.P. | 1,502,788 | 702,694 | -800,094 | 1.12 | 0.24 | -0.88 | sell |