| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,689,545 | 20,064,545 | +9,375,000 | 0.20 | 1.14 | +0.94 | buy |
| Commodore Capital LP | 0 | 2,357,319 | +2,357,319 | 0.00 | 0.53 | +0.53 | buy |
| Vivo Capital, LLC | 0 | 2,325,000 | +2,325,000 | 0.00 | 0.86 | +0.86 | buy |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 3,482,434 | +2,000,000 | 0.00 | 0.04 | +0.04 | buy |
| BVF INC/IL | 0 | 1,915,000 | +1,915,000 | 0.00 | 0.36 | +0.36 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.09 | +0.09 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,333,583 | +1,333,583 | 0.00 | 0.01 | +0.01 | buy |
| TCG Crossover Management, LLC | 0 | 1,200,000 | +1,200,000 | 0.00 | 0.27 | +0.27 | buy |
| Deep Track Capital, LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 0.15 | +0.15 | buy |
| Laurion Capital Management LP | 810,761 | 1,892,156 | +1,081,395 | 0.10 | 1.19 | +1.09 | buy |
| AWM Investment Company, Inc. | 0 | 1,025,000 | +1,025,000 | 0.00 | 0.44 | +0.44 | buy |
| VANGUARD GROUP INC | 937,023 | 1,768,356 | +831,333 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 829,870 | +829,870 | 0.00 | 0.11 | +0.11 | buy |
| EcoR1 Capital, LLC | 0 | 800,000 | +800,000 | 0.00 | 0.18 | +0.18 | buy |
| Logos Global Management LP | 0 | 750,000 | +750,000 | 0.00 | 0.34 | +0.34 | buy |
| Octagon Capital Advisors LP | 0 | 700,000 | +700,000 | 0.00 | 0.50 | +0.50 | buy |
| Siren, L.L.C. | 0 | 700,000 | +700,000 | 0.00 | 0.13 | +0.13 | buy |
| Woodline Partners LP | 691,530 | 1,311,021 | +619,491 | 0.00 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 0 | 575,156 | +575,156 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 481,365 | +481,365 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 389,189 | +389,189 | 0.00 | 0.36 | +0.36 | buy |
| Ikarian Capital, LLC | 150,000 | 535,967 | +385,967 | 0.06 | 0.50 | +0.45 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 315,000 | +315,000 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 45,570 | 350,385 | +304,815 | 0.00 | 0.04 | +0.04 | buy |
| Monashee Investment Management LLC | 0 | 300,000 | +300,000 | 0.00 | 0.69 | +0.69 | buy |
| CITADEL ADVISORS LLC | 0 | 297,258 | +297,258 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.37 | +0.37 | buy |
| UBS Group AG | 0 | 242,451 | +242,451 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 190,256 | +190,256 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 150,192 | +150,192 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 131,632 | +131,632 | 0.00 | 0.00 | +0.00 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 0 | 104,800 | +104,800 | 0.00 | 0.36 | +0.36 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,350,000 | 1,450,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| FIFTH LANE CAPITAL, LP | 0 | 70,000 | +70,000 | 0.00 | 0.32 | +0.32 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 46,158 | +46,158 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 38,081 | +38,081 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 30,670 | +30,670 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 63,740 | 92,493 | +28,753 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 51,300 | 75,700 | +24,400 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 20,001 | +20,001 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 20,352 | 36,842 | +16,490 | 0.00 | 0.02 | +0.01 | buy |
| Militia Capital Partners, LP | 0 | 15,500 | +15,500 | 0.00 | 0.03 | +0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 156,467 | 171,467 | +15,000 | 0.05 | 0.19 | +0.14 | buy |
| NORTHERN TRUST CORP | 47,986 | 59,526 | +11,540 | 0.00 | 0.00 | +0.00 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Burkehill Global Management, LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 35,000 | 44,000 | +9,000 | 0.05 | 0.19 | +0.14 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 6,762 | +6,762 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,264 | 1,268 | +4 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| RBF Capital, LLC | 100,000 | 100,000 | 0 | 0.01 | 0.02 | +0.02 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 808 | 679 | -129 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 137 | 0 | -137 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 505 | 195 | -310 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 201,096 | 200,731 | -365 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,572 | 5,749 | -823 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,570 | 7,839 | -1,731 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 3,704 | 1,156 | -2,548 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 3,576 | 767 | -2,809 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 5,603 | 2,430 | -3,173 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 69,140 | 65,790 | -3,350 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 4,039 | 0 | -4,039 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 6,602 | 1,494 | -5,108 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 39,699 | 33,006 | -6,693 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 8,523 | 1,396 | -7,127 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 15,939 | 0 | -15,939 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 91,923 | 63,000 | -28,923 | 0.00 | 0.01 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 32,705 | 0 | -32,705 | 0.00 | 0.00 | -0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 38,047 | 0 | -38,047 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 39,209 | 0 | -39,209 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 70,603 | 0 | -70,603 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 73,004 | 0 | -73,004 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 240,000 | 75,000 | -165,000 | 0.05 | 0.05 | -0.00 | sell |
| BlackRock, Inc. | 648,021 | 450,126 | -197,895 | 0.00 | 0.00 | +0.00 | sell |
| Prosight Management, LP | 243,980 | 0 | -243,980 | 0.07 | 0.00 | -0.07 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 300,000 | 0 | -300,000 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 2,759,171 | 2,030,000 | -729,171 | 0.01 | 0.02 | +0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,509,198 | 500,266 | -1,008,932 | 0.00 | 0.00 | +0.00 | sell |