| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 988,204 | +988,204 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 680,000 | 1,100,000 | +420,000 | 0.01 | 0.02 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56,300 | 99,200 | +42,900 | 0.01 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 0 | 23,038 | +23,038 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 14,156 | +14,156 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,628 | 13,724 | +12,096 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 199,277 | 210,053 | +10,776 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 16,311 | 19,807 | +3,496 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 502,793 | 506,179 | +3,386 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 301 | 1,370 | +1,069 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 74,735 | 74,825 | +90 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 31,398 | 31,418 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,175 | 1,175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 1,482,434 | 0 | 0.03 | 0.04 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 12,060 | 12,060 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 8,131,952 | 8,131,952 | 0 | 0.81 | 0.86 | +0.05 | hold |
| Rathbones Group PLC | 62,003 | 62,003 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Laurion Capital Management LP | 664,516 | 664,516 | 0 | 0.09 | 0.16 | +0.07 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 486,611 | 486,611 | 0 | 0.13 | 0.15 | +0.02 | hold |
| STRS OHIO | 1,900 | 1,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,790 | 27,790 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 5,016 | 4,996 | -20 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,514 | 6,483 | -31 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 95 | 0 | -95 | 0.00 | 0.00 | 0.00 | sell |
| AMALGAMATED BANK | 1,375 | 1,213 | -162 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 1,138 | 853 | -285 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,218 | 1,654 | -564 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 615 | 0 | -615 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 14,649 | 13,841 | -808 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 1,124 | 123 | -1,001 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,311 | 1 | -1,310 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,397 | 0 | -1,397 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 219,126 | 216,914 | -2,212 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,989 | 1,760 | -2,229 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 6,564 | 0 | -6,564 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 651,050 | 436,813 | -214,237 | 1.01 | 0.46 | -0.55 | sell |
| FMR LLC | 2,365,965 | 738,022 | -1,627,943 | 0.00 | 0.00 | -0.00 | sell |