| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 3,193,097 | +3,193,097 | 0.00 | 0.18 | +0.18 | buy |
| MORGAN STANLEY | 0 | 553,478 | +553,478 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,088,948 | 1,286,126 | +197,178 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 13,822 | 156,636 | +142,814 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 136,262 | +136,262 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,700 | 98,900 | +50,200 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 58,802 | 98,344 | +39,542 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 8,246 | 44,735 | +36,489 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 17,833 | +17,833 | 0.00 | 0.04 | +0.04 | buy |
| HRT FINANCIAL LP | 0 | 14,080 | +14,080 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 45,232 | 57,102 | +11,870 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 149,054 | 157,038 | +7,984 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 315,574 | 322,893 | +7,319 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 40,517 | 47,506 | +6,989 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 6,911 | +6,911 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 26,611 | 31,287 | +4,676 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 21,971 | 26,413 | +4,442 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,327 | 6,050 | +2,723 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,384 | +2,384 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,086 | +1,086 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 11,462 | 12,385 | +923 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 18,380 | 18,954 | +574 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,519 | 8,899 | +380 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 313 | +313 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 195 | +195 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 16 | 27 | +11 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,175 | 1,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,126 | 1,126 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ZACKS INVESTMENT MANAGEMENT | 38,047 | 38,047 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 1,482,434 | 1,482,434 | 0 | 0.05 | 0.02 | -0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 17,650 | 17,650 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,689,545 | 10,689,545 | 0 | 1.05 | 0.54 | -0.51 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 810,761 | 810,761 | 0 | 0.44 | 0.19 | -0.25 | hold |
| Bank of New York Mellon Corp | 33,487 | 33,487 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,678 | 1,678 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,485 | 6,485 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 10,200 | 10,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 48,351 | 48,351 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 337 | 337 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 76 | 0 | -76 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 22,780 | 22,605 | -175 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 8,306 | 7,723 | -583 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 2,100 | 0 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 375,325 | 372,855 | -2,470 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 5,052 | 0 | -5,052 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 919,415 | 912,670 | -6,745 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 8,455 | 0 | -8,455 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 9,420 | 0 | -9,420 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 11,103 | 0 | -11,103 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 11,300 | 0 | -11,300 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 14,800 | 0 | -14,800 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,241 | 0 | -15,241 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 22,738 | 0 | -22,738 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 34,812 | 0 | -34,812 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 60,654 | 14,418 | -46,236 | 0.01 | 0.00 | -0.00 | sell |
| FMR LLC | 61,607 | 582 | -61,025 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 179,200 | 110,000 | -69,200 | 0.26 | 0.07 | -0.18 | sell |
| ORBIMED ADVISORS LLC | 797,358 | 653,016 | -144,342 | 0.12 | 0.05 | -0.07 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,127,536 | 800,000 | -327,536 | 0.02 | 0.01 | -0.01 | sell |
| Octagon Capital Advisors LP | 376,117 | 0 | -376,117 | 0.51 | 0.00 | -0.51 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,660,932 | 1,174,321 | -486,611 | 0.51 | 0.16 | -0.34 | sell |
| PERCEPTIVE ADVISORS LLC | 1,410,438 | 829,536 | -580,902 | 0.26 | 0.09 | -0.17 | sell |
| Frazier Life Sciences Management, L.P. | 702,694 | 0 | -702,694 | 0.24 | 0.00 | -0.24 | sell |
| JANUS HENDERSON GROUP PLC | 2,336,516 | 522,256 | -1,814,260 | 0.01 | 0.00 | -0.01 | sell |