| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 0 | 1,547,229 | +1,547,229 | 0.00 | 0.60 | +0.60 | buy |
| Commodore Capital LP | 2,357,319 | 3,400,000 | +1,042,681 | 0.53 | 1.47 | +0.94 | buy |
| Pictet Asset Management Holding SA | 481,365 | 1,352,424 | +871,059 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 450,126 | 1,234,414 | +784,288 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 575,156 | 1,084,400 | +509,244 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,768,356 | 2,212,834 | +444,478 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 351,141 | +351,141 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 200,731 | 542,109 | +341,378 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 290,589 | +290,589 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 1,025,000 | 1,300,000 | +275,000 | 0.44 | 0.82 | +0.37 | buy |
| Walleye Capital LLC | 0 | 255,974 | +255,974 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 2,030,000 | 2,274,416 | +244,416 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 241,618 | +241,618 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 205,324 | +205,324 | 0.00 | 0.21 | +0.21 | buy |
| JANE STREET GROUP, LLC | 0 | 192,733 | +192,733 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 186,916 | +186,916 | 0.00 | 0.10 | +0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 92,493 | 267,425 | +174,932 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 160,000 | +160,000 | 0.00 | 0.16 | +0.16 | buy |
| Laurion Capital Management LP | 1,892,156 | 2,052,133 | +159,977 | 1.19 | 0.91 | -0.28 | buy |
| STATE STREET CORP | 65,790 | 217,490 | +151,700 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 250,000 | 373,892 | +123,892 | 0.37 | 0.53 | +0.16 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 113,502 | +113,502 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 33,006 | 135,216 | +102,210 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 98,036 | +98,036 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,396 | 89,575 | +88,179 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 75,700 | 147,900 | +72,200 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 69,391 | +69,391 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 350,385 | 417,996 | +67,611 | 0.04 | 0.07 | +0.03 | buy |
| NORTHERN TRUST CORP | 59,526 | 118,257 | +58,731 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 55,438 | +55,438 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,156 | 55,717 | +54,561 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 0 | 50,000 | +50,000 | 0.00 | 0.16 | +0.16 | buy |
| SIMPLEX TRADING, LLC | 0 | 43,194 | +43,194 | 0.00 | 0.01 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 36,125 | +36,125 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 38,081 | 73,306 | +35,225 | 0.00 | 0.00 | +0.00 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 104,800 | 138,398 | +33,598 | 0.36 | 0.59 | +0.23 | buy |
| Qube Research & Technologies Ltd | 0 | 31,234 | +31,234 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 31,213 | +31,213 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,494 | 31,337 | +29,843 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 27,600 | +27,600 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 24,306 | +24,306 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 20,806 | +20,806 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 15,750 | +15,750 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 14,580 | +14,580 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 13,729 | +13,729 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,749 | 11,202 | +5,453 | 0.00 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,268 | 3,341 | +2,073 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,839 | 9,489 | +1,650 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 679 | 1,350 | +671 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| OPTIMA CAPITAL LLC | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BVF INC/IL | 1,915,000 | 1,915,000 | 0 | 0.36 | 0.42 | +0.06 | hold |
| VIKING GLOBAL INVESTORS LP | 3,482,434 | 3,482,434 | 0 | 0.04 | 0.06 | +0.02 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 63,000 | 63,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 829,870 | 829,870 | 0 | 0.11 | 0.10 | -0.01 | hold |
| JANUS HENDERSON GROUP PLC | 1,500,000 | 1,500,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 20,064,545 | 20,064,545 | 0 | 1.14 | 1.34 | +0.20 | hold |
| Rathbones Group PLC | 32,003 | 32,003 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 2,325,000 | 2,325,000 | 0 | 0.86 | 0.98 | +0.11 | hold |
| Woodline Partners LP | 1,311,021 | 1,311,021 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Octagon Capital Advisors LP | 700,000 | 700,000 | 0 | 0.50 | 0.57 | +0.07 | hold |
| ADAR1 Capital Management, LLC | 36,842 | 36,842 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Siren, L.L.C. | 700,000 | 700,000 | 0 | 0.13 | 0.14 | +0.01 | hold |
| NISA INVESTMENT ADVISORS, LLC | 195 | 195 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 315,000 | 315,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| FMR LLC | 2,430 | 1,664 | -766 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 767 | 0 | -767 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 46,158 | 43,440 | -2,718 | 0.02 | 0.02 | +0.01 | sell |
| RBF Capital, LLC | 100,000 | 95,042 | -4,958 | 0.02 | 0.03 | +0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 131,632 | 125,498 | -6,134 | 0.00 | 0.00 | +0.00 | sell |
| Rangeley Capital, LLC | 44,000 | 36,200 | -7,800 | 0.19 | 0.20 | +0.01 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 10,000 | 0 | -10,000 | 0.01 | 0.00 | -0.01 | sell |
| Burkehill Global Management, LP | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 20,001 | 10,001 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Militia Capital Partners, LP | 15,500 | 0 | -15,500 | 0.03 | 0.00 | -0.03 | sell |
| CITADEL ADVISORS LLC | 297,258 | 267,789 | -29,469 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 171,467 | 121,467 | -50,000 | 0.19 | 0.17 | -0.02 | sell |
| ExodusPoint Capital Management, LP | 190,256 | 120,728 | -69,528 | 0.01 | 0.01 | -0.00 | sell |
| FIFTH LANE CAPITAL, LP | 70,000 | 0 | -70,000 | 0.32 | 0.00 | -0.32 | sell |
| Opaleye Management Inc. | 75,000 | 0 | -75,000 | 0.05 | 0.00 | -0.05 | sell |
| Ikarian Capital, LLC | 535,967 | 447,165 | -88,802 | 0.50 | 0.38 | -0.12 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 150,192 | 20,838 | -129,354 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 242,451 | 0 | -242,451 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 300,000 | 0 | -300,000 | 0.69 | 0.00 | -0.69 | sell |
| MILLENNIUM MANAGEMENT LLC | 500,266 | 197,943 | -302,323 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 389,189 | 0 | -389,189 | 0.36 | 0.00 | -0.36 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,333,583 | 866,269 | -467,314 | 0.01 | 0.01 | -0.00 | sell |
| Logos Global Management LP | 750,000 | 0 | -750,000 | 0.34 | 0.00 | -0.34 | sell |
| EcoR1 Capital, LLC | 800,000 | 0 | -800,000 | 0.18 | 0.00 | -0.18 | sell |
| TCG Crossover Management, LLC | 1,200,000 | 0 | -1,200,000 | 0.27 | 0.00 | -0.27 | sell |
| Deep Track Capital, LP | 1,200,000 | 0 | -1,200,000 | 0.15 | 0.00 | -0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,450,000 | 100,000 | -1,350,000 | 0.01 | 0.00 | -0.01 | sell |
| RTW INVESTMENTS, LP | 1,500,000 | 0 | -1,500,000 | 0.09 | 0.00 | -0.09 | sell |