| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 2,357,319 | 3,400,000 | +1,042,681 | 0.53 | 1.47 | +0.94 | buy |
| AWM Investment Company, Inc. | 1,025,000 | 1,300,000 | +275,000 | 0.44 | 0.82 | +0.37 | buy |
| Laurion Capital Management LP | 1,892,156 | 2,052,133 | +159,977 | 0.15 | 0.50 | +0.35 | buy |
| Boxer Capital Management, LLC | 250,000 | 373,892 | +123,892 | 0.37 | 0.53 | +0.16 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 104,800 | 138,398 | +33,598 | 0.36 | 0.59 | +0.23 | buy |
| China Universal Asset Management Co., Ltd. | 5,749 | 11,202 | +5,453 | 0.00 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 679 | 1,350 | +671 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 100,000 | 95,042 | -4,958 | 0.02 | 0.03 | +0.01 | sell |
| Rangeley Capital, LLC | 44,000 | 36,200 | -7,800 | 0.18 | 0.20 | +0.02 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 171,467 | 121,467 | -50,000 | 0.17 | 0.15 | -0.01 | sell |
| Ikarian Capital, LLC | 535,967 | 447,165 | -88,802 | 0.50 | 0.38 | -0.12 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,450,000 | 100,000 | -1,350,000 | 0.01 | 0.00 | -0.01 | sell |