| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 763,199 | +763,199 | 0.00 | 0.36 | +0.36 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 135,223 | +135,223 | 0.00 | 0.00 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 25,135 | 45,064 | +19,929 | 0.07 | 0.08 | +0.02 | buy |
| XTX Topco Ltd | 0 | 15,178 | +15,178 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,426 | 4,089 | +2,663 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 375 | +375 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 200 | 559 | +359 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 1,793 | 1,860 | +67 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Steigerwald, Gordon & Koch Inc. | 1,250 | 1,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 2,291,666 | 2,291,666 | 0 | 0.37 | 0.26 | -0.11 | hold |
| Smartleaf Asset Management LLC | 43 | 43 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VSM Wealth Advisory, LLC | 10,000 | 10,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| GENERAL AMERICAN INVESTORS CO INC | 354,361 | 354,361 | 0 | 0.15 | 0.11 | -0.03 | hold |
| Clearstead Advisors, LLC | 48 | 0 | -48 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 91 | 0 | -91 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 78,029 | 77,214 | -815 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,000 | 0 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| OLD MISSION CAPITAL LLC | 13,759 | 0 | -13,759 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 20,847 | 0 | -20,847 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 1,057,421 | 0 | -1,057,421 | 0.54 | 0.00 | -0.54 | sell |