| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 338,542 | +338,542 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 30,351 | 70,198 | +39,847 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 209,700 | 249,446 | +39,746 | 0.00 | 0.00 | +0.00 | buy |
| SevenBridge Financial Group, LLC | 0 | 31,000 | +31,000 | 0.00 | 0.01 | +0.01 | buy |
| PFG Investments, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 29,500 | +29,500 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 27,500 | +27,500 | 0.00 | 0.02 | +0.02 | buy |
| Summit Trail Advisors, LLC | 0 | 16,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 902,531 | 902,531 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 84,826 | 84,826 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 1,475,121 | 1,475,121 | 0 | 0.25 | 0.55 | +0.30 | hold |
| Rock Springs Capital Management LP | 1,440,759 | 1,440,759 | 0 | 0.02 | 0.04 | +0.02 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,805,413 | 2,805,413 | 0 | 0.15 | 0.24 | +0.10 | hold |
| Qube Research & Technologies Ltd | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Key FInancial Inc | 830 | 830 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dunhill Financial, LLC | 10,274 | 10,274 | 0 | 0.01 | 0.01 | +0.01 | hold |
| FMR LLC | 1,907,671 | 1,907,671 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIL Ltd | 218,705 | 218,705 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 17,798 | 17,798 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,925 | 11,925 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 15,690 | 15,690 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CULLEN/FROST BANKERS, INC. | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,975 | 11,153 | -2,822 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 10,763 | 0 | -10,763 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 83,373 | 0 | -83,373 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 155,481 | 71,081 | -84,400 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 116,847 | 0 | -116,847 | 0.00 | 0.00 | -0.00 | sell |
| Artal Group S.A. | 450,000 | 0 | -450,000 | 0.01 | 0.00 | -0.01 | sell |
| Atlas Venture Life Science Advisors, LLC | 2,759,344 | 992,912 | -1,766,432 | 0.18 | 0.10 | -0.08 | sell |
| Octagon Capital Advisors LP | 1,785,000 | 0 | -1,785,000 | 0.16 | 0.00 | -0.16 | sell |